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New Therapies may Help to Avoid Transplant in Some Heart Failure Patients

tation found evidence of important improvements.

The size of the heart muscle cells, the amount of the fibrous collagen and levels of the protein TNF-alpha all decreased significantly between pump implant and heart transplant signs of reduced heart damage.

"We now have a much more reliable description of the natural history of the changes in heart function during LVAD support," Maybaum said. "That makes us optimistic that other strategies may allow us to further improve cardiac function."

Two novel strategies will soon be tested in clinical trials for LVAD patients in the U.S. One study will utilize the muscle bulking agent clenbuterol and the second will evaluate autologous (the patients own) stem cells injected at the time of LVAD implantation.


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