Navigation Links
New Study To Identify Osteoporosis Genes

More than 2,000 people are being recruited from Orkney, Scotland as a part of a major new study that wants to identify genes that cause osteoporosis. //The study is to be funded by Arthritis Research Campaign and people from Westray, Sanday, Stronsay and Shapinsay, as well as those from the west of the Mainland of Orkney are expected to act as volunteers. The study may cost £240,000 over the next three years.

The investigation will be carried out by a team of researchers from the University of Edinburgh led by Professor of Rheumatology Stuart Ralston, and Royal Society Research Fellow, Dr Jim Wilson, who comes from Orkney.

Previous research has shown that people with a family history of osteoporosis are at increased risk of suffering from the condition themselves. This appears to be due to the inheritance of genes that predispose them to reduced bone mineral density.

The people of Orkney have been specifically selected by the Edinburgh team because the population is both isolated and stable, and specific genes will be easier to track down and identify.

"Although some genes that predispose people to osteoporosis have been identified, most remain to be discovered," explained Professor Ralston, who is based at the Rheumatic Diseases Unit in the university's Molecular Medicine Centre at the Western General Hospital. "With this project we will carry out genetic mapping studies in several large families from an isolated population in Orkney to try and discover the location and identify the genes that influence bone density and predispose to this common condition. We know that genetic factors make about an 80 per cent contribution to people developing low bone density, but we only know about five per cent of them."

"You couldn't do this sort of study in a large city like Edinburgh because there are people from all over the world and therefore too many genetic influences, so it would be very hard to disentangle those th at are involved in predisposition to osteoporosis," said Dr Wilson, from the MRC Human Genetics Unit at the Western General.

"If 100 people in a big city had osteoporosis there might be 100 different reasons why they had it, many of which would be genetic. But on a small island there would be many fewer genetic reasons, which would make each one easier to identify."

Although the gene pool among Orkney families is isolated from the rest of the UK population, it is expected that the results of the study will still be applicable to the wider population, as have results from studies in Iceland.

The new study will piggyback on an existing research project in Orkney (ORCADES) which has involved 1, 400 volunteers and is looking at genetic influences on cardiovascular disease.

Two research nurses will run sessions to test the bone density of volunteers in Kirkwall, Orkney's largest town, which is regularly visited by people living on the smaller isles.

Recruits will have their bone mineral density tested on a DEXA (Dual Energy X-ray Bone Densitometer) machine, and if they are found to have thin bones will be offered appropriate treatment via their GP. They will also have blood samples taken, and a genome wide scan carried out on their DNA in laboratories in Edinburgh.

Professor Ralston said he and the rest of the team were confident that new genes that predispose people to osteoporosis would be found during the course of the project.

"If our studies are successful, the results will be of value in developing genetic tests with which to assess the risk of fractures occurring, and new drugs that can be used for the prevention and treatment of osteoporosis," he added.

Recruitment will start this month. Source: Eurekalert
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
(Date:6/24/2016)... ... 24, 2016 , ... The Pulmonary Hypertension Association (PHA) learned ... receive two significant new grants to support its work to advance research and ... by recognizing patients, medical professionals and scientists for their work in fighting pulmonary ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... today at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra ... authored journal articles published in Emergency Medicine Practice and Pediatric Emergency ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American Respiratory ... testing company, is now able to perform sophisticated lung assessments in ... Medical Technologies , Inc. Patients are no longer ... to ndd,s EasyOne PRO ® , ARL patients like Jeanne R. ... testing done in the comfort of her own home. ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
Breaking Medicine Technology: