Navigation Links
New Study To Identify Osteoporosis Genes

More than 2,000 people are being recruited from Orkney, Scotland as a part of a major new study that wants to identify genes that cause osteoporosis. //The study is to be funded by Arthritis Research Campaign and people from Westray, Sanday, Stronsay and Shapinsay, as well as those from the west of the Mainland of Orkney are expected to act as volunteers. The study may cost £240,000 over the next three years.

The investigation will be carried out by a team of researchers from the University of Edinburgh led by Professor of Rheumatology Stuart Ralston, and Royal Society Research Fellow, Dr Jim Wilson, who comes from Orkney.

Previous research has shown that people with a family history of osteoporosis are at increased risk of suffering from the condition themselves. This appears to be due to the inheritance of genes that predispose them to reduced bone mineral density.

The people of Orkney have been specifically selected by the Edinburgh team because the population is both isolated and stable, and specific genes will be easier to track down and identify.

"Although some genes that predispose people to osteoporosis have been identified, most remain to be discovered," explained Professor Ralston, who is based at the Rheumatic Diseases Unit in the university's Molecular Medicine Centre at the Western General Hospital. "With this project we will carry out genetic mapping studies in several large families from an isolated population in Orkney to try and discover the location and identify the genes that influence bone density and predispose to this common condition. We know that genetic factors make about an 80 per cent contribution to people developing low bone density, but we only know about five per cent of them."

"You couldn't do this sort of study in a large city like Edinburgh because there are people from all over the world and therefore too many genetic influences, so it would be very hard to disentangle those th at are involved in predisposition to osteoporosis," said Dr Wilson, from the MRC Human Genetics Unit at the Western General.

"If 100 people in a big city had osteoporosis there might be 100 different reasons why they had it, many of which would be genetic. But on a small island there would be many fewer genetic reasons, which would make each one easier to identify."

Although the gene pool among Orkney families is isolated from the rest of the UK population, it is expected that the results of the study will still be applicable to the wider population, as have results from studies in Iceland.

The new study will piggyback on an existing research project in Orkney (ORCADES) which has involved 1, 400 volunteers and is looking at genetic influences on cardiovascular disease.

Two research nurses will run sessions to test the bone density of volunteers in Kirkwall, Orkney's largest town, which is regularly visited by people living on the smaller isles.

Recruits will have their bone mineral density tested on a DEXA (Dual Energy X-ray Bone Densitometer) machine, and if they are found to have thin bones will be offered appropriate treatment via their GP. They will also have blood samples taken, and a genome wide scan carried out on their DNA in laboratories in Edinburgh.

Professor Ralston said he and the rest of the team were confident that new genes that predispose people to osteoporosis would be found during the course of the project.

"If our studies are successful, the results will be of value in developing genetic tests with which to assess the risk of fractures occurring, and new drugs that can be used for the prevention and treatment of osteoporosis," he added.

Recruitment will start this month. Source: Eurekalert
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/12/2017)... ... 12, 2017 , ... CitiDent and San Francisco dentists, Dr. ... Oventus O2Vent technology. As many as 18 million Americans are estimated to suffer ... Oral appliances can offer significant relief to about 75 percent of people with ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) will ... during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual ... F. Collen, a pioneer in the field of medical informatics, this prestigious award is ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare ... Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during ... , The annual award competition recognizes editorial and design excellence across a range of ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... nation's first interactive health literacy software tool, and the Cancer Patient Education Network ... cancer patient education, today announce a new strategic alliance. , As CPEN’s ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... 2017   Provista, a proven leader in ... in purchasing power, today announced a new resource area ... Newsroom is the online home for case studies, ... bios, news releases, slideshows and events. ... of resources at their fingertips, viewers can also watch ...
(Date:10/4/2017)... Centers for Disease Control and Prevention (CDC), influenza vaccination should take ... communities across Massachusetts , Connecticut , ... through the end of the month. *Some exclusions apply ... ... by the end of October, according to the Centers for Disease Control ...
(Date:10/2/2017)... INDIANAPOLIS , Oct. 2, 2017  Eli Lilly ... its financial results for the third quarter of 2017 ... a conference call on that day with the investment ... performance. The conference call will begin at ... public can access a live webcast of the conference ...
Breaking Medicine Technology: