( f 100 micrograms iodine per liter of ur...)New Study Suggests Perchlorate Effects on Thyroid Function of U.S. Women,Health

f 100 micrograms iodine per liter of urine (μg/L), then compared the women’s urinary perchlorate concentrations to their blood levels of T4 and TSH. They found a slight relationship between perchlorate concentrations and TSH for the higher-iodine group, but a much stronger one for perchlorate and both T4 and TSH in women in the lower-iodine group.

For the lower-iodine group, increased perchlorate was associated with less production of T4 and more production of TSH (which usually is produced to stimulate T4), suggesting competitive inhibition of thyroid iodine uptake by perchlorate. Women at the 50th percentile for urinary perchlorate had levels of 2.9 μg/L perchlorate, which predicted a decrease in T4 of 1.06 μg/dL; at the 95th percentile of perchlorate (13 μg/L), the predicted decrease in T4 was 1.64 μg/dL. Although the size of perchlorate’s predicted effect on T4 and TSH was small to moderate depending on the amount of perchlorate exposure, given that the normal range of T4 for women is between 5 and 12 μg/dL, these predicted reductions were significant and indicate that even small increases in perchlorate exposure may inhibit the thyroid’s ability to absorb iodine from the bloodstream.

In the United States, 36% of women have urinary iodine levels less than 100 μg/L, the same as the women in the lower-iodine group in the study. This study is the first to examine women with lower iodine levels for a potential effect of perchlorate on thyroid function. CDC researchers say that since this is the first time studying these women, another large study is needed to confirm these findings; they are planning that study.

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