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New Study Shows Efficacy of AROMASIN on Early Breast Cancer

rmonal therapy. This indication is based on the results of the IES study. Study results from a median follow-up of 34.5 months showed that switching to AROMASIN after two to three years of tamoxifen, for a total of five years treatment resulted in a 31% lower risk of breast cancer recurrence than staying on tamoxifen in the intent-to-treat [ITT] population. The results also demonstrated a 35% risk reduction in breast cancer recurrence for patients with hormone receptor-positive breast cancer. Overall survival data were not statistically significant at 34.5 months.

Updated 56 month follow-up data, presented at the 2006 American Society of Clinical Oncology (ASCO) meeting, demonstrate a 17% overall survival benefit in the ITT population and a 25% lower risk of breast cancer recurrence for patients with ER+/unknown breast cancer.

Aromasin is also indicated for the treatment of advanced breast cancer in women with natural or induced postmenopausal states, whose disease has progressed following tamoxifen therapy.

Aromasin was approved in the United States in 2005 for treatment of postmenopausal women with estrogen-receptor positive early breast cancer following two to three years of tamoxifen, for a combined total of five consecutive years of therapy. It also is approved for use in Canada, Europe, Japan and South America. Currently, Aromasin is available in more than 80 countries and is approved in the early breast cancer setting in more than 40 countries.

Aromasin should not be used in women who are premenopausal, are nursing or pregnant, have a known hypersensitivity to the drug, or are taking estrogen-containing agents. Dose modification is recommended for patients who are receiving certain medications, including strong CYP 3A4 inducers such as rifampicin and phenytoin.

In patients with early breast cancer, elevations in bilirubin, alkaline phosphatase, and creatinine were more common in those receiving Aro
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