NCIC MA.17 trial. By this time, about half the intended number of patients had been enrolled (1598) and the study was unblinded. All patients receiving placebo were offered Aromasin and 44% of such patients chose to cross over to Aromasin. The majority of patients on the Aromasin arm (72%) continued with the trial.
In addition to disease free survival and relapse free survival, the B-33 trial also evaluated overall survival. At 30 months median follow-up, no overall survival benefit was shown (13 deaths on placebo vs. 16 on Aromasin, HR=1.2, P=0.63).
Toxicity experienced with Aromasin in the B-33 trial was acceptable for the adjuvant setting. Up until the time of unblinding, the most common grade 3-4 toxicities in Aromasin vs. placebo were arthralgia (1.0% vs. 0.5%), fatigue (0.9% vs. 0.5%) and bone pain (0.5% vs. 0.7%). At six months after the unblinding of the study, there was no statistically significant difference in fractures with Aromasin in comparison to placebo – 28 patients with fractures in the Aromasin arm vs. 20 in the placebo arm (P=0.33), and no differences were experienced in a range of quality of life categories; vasomotor, psychosocial, physical or sexual symptoms.
About Breast Cancer
Breast cancer is the second most common cancer among women. Every year, more than one million women worldwide are diagnosed with the disease. Estrogen is one of the most significant contributors to the development of breast cancer: and two-thirds of all breast cancer cases are estrogen-dependent. Hormonal therapy, such as Aromasin, is an important treatment option for early breast cancer.
Aromasin is currently indicated for the adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer who have received two to three years of tamoxifen and are switched to Aromasin for the completion of a total of five consecutive years of adjuvant hoPage: 1 2 3 4 Related medicine news :1
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