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New Study Shows Efficacy of AROMASIN on Early Breast Cancer

New data from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-33 study, presented today at the San Antonio Breast Cancer Symposium, showed that// postmenopausal women with hormone receptor-positive breast cancer who received Aromasin after five years of tamoxifen were 56% less likely to have a relapse of breast cancer than those who received placebo (P=0.004).

“Aromasin provided patients with improved relapse-free survival despite early study closure, unblinding and crossover in the placebo arm,” said Dr. Terry Mamounas, NSABP breast committee chairman and lead investigator for the B-33 study. Median follow-up of 30 months also showed that disease-free survival was improved by 32% (P=0.07). Toxicity experienced with Aromasin in the B-33 trial was acceptable for the adjuvant setting.

These results continue to add to the body of evidence supporting the use of Aromasin after tamoxifen. According to Professor Charles Coombes, lead investigator for the landmark Intergroup Exemestane Study (IES) and director of cancer medicine, Imperial College, London, “Results from the IES show a clear benefit for women who receive Aromasin after two to three years of tamoxifen. The B-33 study results presented today show that Aromasin is also effective in the extended adjuvant setting after five years of tamoxifen.”

About B-33

The B-33 trial was a randomized, placebo-controlled, double-blind trial open to hormone receptor-positive breast cancer patients who were breast cancer free, having completed about five years of tamoxifen therapy – the standard treatment at the time of the start of the trial. Patients were randomly assigned to receive either exemestane or placebo for two years, which was later extended to five years in order to assess the clinical benefits of using Aromasin in the extended adjuvant setting.

Accrual of the B-33 study stopped in October 2003, after disclosure of results from the
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