Navigation Links
New Study Finds On/Off Switch for Septic Shock

According to a new study, septic shock—a dangerous, often deadly runaway immune response—is controlled by a genetic on/off switch. The research also suggests how a drug might// temper sepsis. This is the first time this genetic mechanism has been revealed in an experimental animal.

The study by Robert Schneider, Ph.D., the Albert B. Sabin Professor of Microbiology and Molecular Pathogenesis at NYU School of Medicine and his colleagues, was published in the November 3, 2006 advance online edition of the journal Genes & Development.

A killer and a protector

Septic shock is the nation’s 10th most frequent cause of death and the leading cause of hospital-related mortality. Bacterial infection, notably the toxins that are part of the bacterial cell wall, stimulate the inflammatory response which can spin out of control. Sepsis progresses swiftly from chills, fever and shallow breathing, to dilated and leaky blood vessels, a lack of blood supply in the body’s organs, multiple organ failure and, often, death.

Infection causes the body’s immune system to produce protective proteins called cytokines. Problems arise when the body is unable to turn off cytokine production and they overwhelm the body, says Dr. Schneider. “The resulting cytokine storm is, for example, what kills people when they are infected with anthrax and, we think, an important factor in what killed people in the flu pandemic of 1918,” he says.

Dr. Schneider and his colleagues focused on one of the key genes that regulate cytokine production called auf1, which has been extensively studied in tissue culture but not in animals. In an attempt to move the research closer to the clinical setting, the team genetically engineered and bred mice lacking the auf1 gene, a so-called knock-out mouse. Then, mice with the gene and mice without it were exposed to a bacterial toxin that causes mild food poisoning. The normal mice had little problem fending off the
'"/>




Page: 1 2

Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Study Finds Off Switch for Septic Shock

(Date:5/1/2015)... 2015 Royal River Natural Foods, a ... on a new study that found two natural nutrients, ... improved physical function as well as standard drug treatment ... the knee. , The report is part of the ... Being® ,” which Royal River Natural Foods publishes for ...
(Date:5/1/2015)... 01, 2015 TROY Healthcare Solutions is ... Regional User Group (RUG) Conference in Atlanta, GA from ... User Group Conference provides a forum for client-to-client presentations, ... all aspects of electronic medical record operations, as well ... applications. , In addition to sponsoring the event, TROY ...
(Date:5/1/2015)... Hope For The Warriors® thanks All American ... Warriors® and military families. All American Ford presented two ... Warriors®, a national nonprofit dedicated to restoring a sense ... for our service members and our military families. , ... and matched small autograph fee from fans and presented ...
(Date:5/1/2015)... Yorba Linda, CA (PRWEB) May 01, 2015 ... of our genetic makeup and the interplay of genes ... Keeping up with developments can be daunting. , LabRoots, ... sciences and clinical diagnostics professionals, will soon host its ... Genomics. , At BioConference Live Genetics and Genomics ...
(Date:5/1/2015)... D.C. (PRWEB) May 01, 2015 Today the ... is expanding its fundraising efforts to help protect the rights ... first new program support country added since Girl Up began ... fundraising campaign aimed at supporting adolescent girls in the Rajasthan ... Girl Up has supported the advancement of adolescent girls in ...
Breaking Medicine News(10 mins):Health News:New Study Finds Nutrients Ease Arthritis Pain, Retailer Reports 2Health News:TROY Healthcare to Exhibit at the Cerner Southeast Regional User Group Conference 2Health News:TROY Healthcare to Exhibit at the Cerner Southeast Regional User Group Conference 3Health News:All American Ford Presents Donation to Nonprofit Hope For The Warriors 2Health News:Recent Advances in Genetics and Genomics: A BioConference Live 2015 Virtual Event 2Health News:Recent Advances in Genetics and Genomics: A BioConference Live 2015 Virtual Event 3Health News:United Nations Foundation’s Girl Up Campaign Announces New Funding Initiative to Support Adolescent Girls in India 2Health News:United Nations Foundation’s Girl Up Campaign Announces New Funding Initiative to Support Adolescent Girls in India 3
... (HealthDay News) -- Cotton swabs offer a cheap, effective ... Daily use of dry cotton swabs to gently ... dramatically reduced surgical site infections, the study revealed. Only ... developed infections, compared with 19 percent of patients in ...
... News) -- The number of U.S. workers aged 16 and ... than half over the past two decades -- from 14 ... 2009, a new study reveals. "Although the prevalence of ... lead exposure are well characterized," researchers from the U.S. Centers ...
... University of Gothenburg, have identified a series of ... carry specific sugar molecules, are found in greater concentrations ... in patients with dementia caused by other diseases. This ... future. , Gran Larson is a professor at the ...
... bacteria are proving effective platforms for delivering medicines and ... building blocks for tiny battery electrodes and computer data ... research over the last two decades, with explanations aimed ... and outside the field, is described in a new ...
... N.C. June 30, 2011 Insomnia is the ... of the adult population in the United States on ... Center is conducting the first ever, randomized, controlled clinical ... treat people with insomnia. Brainwave Optimization is a non-invasive ...
... children who watch adverts for unhealthy food on television are more ... study by researchers in the Institute of Psychology, Health and Society ... six to 13 years old from the North West of England. ... cartoon before being shown it again two weeks later. In ...
Cached Medicine News:Health News:Cotton Swabs Help Prevent Surgical Site Infections: Study 2Health News:On-the-Job Lead Exposures Falling, But Still a Problem: CDC 2Health News:New clues to the cause of Alzheimer's disease 2Health News:Turning agents of disease into tools for health and better living 2Health News:Wake Forest Baptist conducts clinical study for insomnia using new technology 2Health News:TV food advertising increases children's preference for unhealthy foods 2
(Date:5/1/2015)... ATLANTA , May 1, 2015 At ... May 2-6 in Washington D.C. , ... a solution that enables clinicians to leverage the enormous ... Knife radiosurgery treatments conducted each year – to advance ... "Gamma Knife Registry is a cloud-based solution that allows ...
(Date:5/1/2015)... 2015 Braeburn Pharmaceuticals announced today ... focus beyond addiction and pain to include ... has acquired an implantable, six-month formulation of ... treatment of schizophrenia from Endo Pharmaceuticals. With ... to other potential applications of the implant ...
(Date:5/1/2015)... , May 1, 2015  Legendary actor and ... in a new PBAFacts campaign designed to educate and ... learn more about Pseudobulbar Affect (PBA) and to speak ... that an actor has the ability to cry and ... lack of control experienced by people living with PBA ...
Breaking Medicine Technology:Elekta to showcase Leksell Gamma Knife Registry at AANS Annual Meeting 2Elekta to showcase Leksell Gamma Knife Registry at AANS Annual Meeting 3Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 2Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 3Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 4Danny Glover Joins PBA Facts Campaign, to Educate and Build Awareness of Pseudobulbar Affect (PBA), a Little Known but Widespread Neurologic Condition 2Danny Glover Joins PBA Facts Campaign, to Educate and Build Awareness of Pseudobulbar Affect (PBA), a Little Known but Widespread Neurologic Condition 3
... Sheets: MDBX ) ( www.thedispensingsolution.com ) announced today ... secure medicine storage and retrieval system. This ... their filled prescriptions from a convenient self-serve system that could ... process is as simple as it is ingenious: When a ...
... WASHINGTON, Nov. 16, 2011 The Personalized Medicine ... its landmark report, The Case for Personalized ... commercially available personalized medicine products from 13 in ... the continued development and adoption of personalized medicine ...
Cached Medicine Technology:MedBox Develops Patent-Pending System for Storage and Retrieval of Prescription Drugs 272 Prominent Personalized Medicine Products Available; A Five-Fold Increase in Five Years 2
... Featuring up to ... allows examination in the ... sections plus the option ... for corneal transillumination., ,Filters ...
... to 20 tilting tower ... the vertical, horizontal and ... option to offset the ... ,Filters include Cobalt blue; ...
... outstanding optical system of the Keeler SL-40H, ... fibre optic illumination system with diffuser added ... camera. The result is an excellent digital ... option of capturing stills or video clips ...
With a high lens and filter range this ophthalmoscope is ideal for the Primary Care Specialist...
Medicine Products: