Navigation Links
New Strategy for the Treatment of CML

Virginia Commonwealth University Massey Cancer Center researchers have identified an approach to enhance the activity of a new //anti-cancer agent that has already shown impressive efficacy in the treatment of chronic myelogenous leukemia.

Chronic myelogenous leukemia, or CML, is a cancer of the bone marrow caused by a specific genetic abnormality and is one of the more common forms of leukemia. Imatinib mesylate (Gleevec) is a highly effective anti-cancer agent that has revolutionized the course of therapy for patients with CML. It works by inhibiting the activity of a mutant protein, known as Bcr/ABl, which is responsible for this disease. However, despite initial success, patients eventually become resistant to imatinib mesylate.

According to Steven Grant, M.D., Massey's associate director for translational research and co-leader of the cancer center's cancer cell biology program, and senior author of the study, resistance to imatinib mesylate has prompted the development of newer generation inhibitors, such as a compound known as dasatinib, which are not only considerably more potent than imatinib mesylate, but also are active against cells expressing many of the mutations that make them resistant to the latter agent.

Dasatinib also inhibits another important survival protein known as Src. However, Grant said that not all patients respond to dasatinib, and the risk remains that patients will develop resistance to this agent as well.

To address this problem, Grant and colleagues examined the effects of combining dasatinib with PD184352, another clinically relevant small molecule inhibitor of a critical cellular survival pathway that inactivates an important survival protein known as ERK1/2 (extracellular-signal regulating kinase1/2). The article was pre-published as a First Edition Paper in Blood, the journal of the American Society of Hematology, which appeared online Jan. 11.

By blocking this pathway, PD184352
'"/>




Page: 1 2 3

Related medicine news :

1. Novel Strategy To Combat Alzheimer’s Disease
2. "Defensive Pessimism" Before Exam Results Not a Good Strategy
3. WHO Devises New Global Strategy To Fight Tuberculosis
4. HER-2 Positive Breast Cancer Patients May Benefit With a Combo Drug Strategy
5. West Nile Virus Can Be Tackled By New Strategy
6. Australia Set To Implement A national Strategy Tackle Cannabis Abuse
7. Clement Urged to Plot a National Pharmaceutical Strategy
8. New Preventive Strategy to Fight Childhood Obesity
9. Rae unveils Health-care Strategy
10. A Promising New Vaccination Strategy for Late-Stage Melanoma
11. Effective Strategy Against Bird flu-Spainish Flu Vaccine Raises Hopes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Strategy for the Treatment CML

(Date:7/31/2014)... Flagstaff, AZ (PRWEB) July 31, 2014 ... long-term substance abuse treatment program in Flagstaff, AZ, learn ... an understanding of equipment and paddle strokes in preparation ... Juan River. , "I think that [the kayaking course] ... things that they struggle with in their early part ...
(Date:7/31/2014)... CA (PRWEB) July 31, 2014 Dr. ... closure in front of an enthusiastic audience of international ... Trichophytic Closure improves the appearance of a patient’s ... results of this procedure are minimally detectable in most ... technique improves on the original method of donor wound ...
(Date:7/31/2014)... July 31, 2014 Located on one of ... Macy’s, The Rothenberg Law Firm LLP has moved its office ... , The Rothenberg Law Firm has been handling catastrophic personal ... spurred by growth in the firm’s continued success in seeking ... New York office has a team of experienced and successful ...
(Date:7/31/2014)... To further educate the public, The Rothenberg Law ... information regarding leaving children in hot vehicles: , Leaving ... Because a child’s body can heat up three to ... alone in a hot vehicle puts them at extreme ... of Children Left Alone in a Car , According ...
(Date:7/31/2014)... Village, IL (PRWEB) July 31, 2014 ... solutions, today announced a new sponsorship of the ... and center are Etymotic’s hearing protection products ETY•Plugs® ... while protecting against the harmful effects of high-level ... off the sponsorship at the Drum Corps International ...
Breaking Medicine News(10 mins):Health News:Back2Basics Substance Abuse Residents Take Kayaking Class for the First Time 2Health News:Novel Technique in Wound Closure Delivers More Discreet Results in Hair Transplant Patients 2Health News:The Rothenberg Law Firm LLP Teams Up with Local Philadelphia TV Stations to Promote Awareness of the Dangers of Leaving Children Unattended in a Hot Vehicle 2Health News:The Rothenberg Law Firm LLP Teams Up with Local Philadelphia TV Stations to Promote Awareness of the Dangers of Leaving Children Unattended in a Hot Vehicle 3Health News:Etymotic Research Becomes The Official Hearing Protection Sponsor Of DrumLine Battle 2
... drinks is associated with binge drinking, alcohol-related social problems ... researchers at the University at Buffalo,s Research Institute on ... Journal of Caffeine Research this spring, UB ... examined substance use by 226 Western New York ...
... , MONDAY, June 20 (HealthDay News) -- Nearly 6 million ... allergic to at least one food, with peanuts, milk and shellfish ... finds. Researchers conducted a nationally representative survey of the parents ... child who had a food allergy. Of those, about 30 percent ...
... -- Cardiac arrest victims are more likely to survive if ... using a defibrillator to deliver an electric shock to the ... of 815 American and Canadian patients who suffered sudden cardiac ... using either an automated external defibrillator or a manual defibrillator. ...
... , MONDAY, June 20 (HealthDay News) -- For gay ... on the support of the local community, a new study ... who reveal their sexual orientation typically boost their self-esteem and ... that disclosing one,s sexual identity makes people even happier than ...
... low-calorie potato chips and other foods could backfire and ... study published by the American Psychological Association. The ... wisdom that foods made with fat substitutes help with ... interfere with the body,s ability to regulate food intake, ...
... The overall risk of injury and concussion among young ice ... they,re first allowed to bodycheck, according to a new study. ... Alberta, which allowsbodychecking at the Pee Wee level (ages 11 ... Bantam level (ages 13 to 14). The study included ...
Cached Medicine News:Health News:Energy drinks linked to substance use in musicians, study shows 2Health News:Energy drinks linked to substance use in musicians, study shows 3Health News:One in 12 U.S. Children May Have Food Allergies: Report 2Health News:One in 12 U.S. Children May Have Food Allergies: Report 3Health News:Faster Transition From CPR to Defibrillator May Save Lives 2Health News:Support Is Key to 'Coming Out' Process for Gay People: Study 2Health News:Fat substitutes linked to weight gain 2Health News:Results of Bodychecking in Youth Hockey Examined 2
(Date:7/31/2014)...  UBM Medica US announces that Cancer ... presents exclusive slide shows dealing with communication in the ... care. Cancer Network, the online ... blogs, and podcasts about the latest clinical findings. Among ... , End-of-life care is challenging for even the ...
(Date:7/31/2014)... July 31, 2014 Touro University California,s College ... selected as the recipient of a $150,000 grant by ... the University to increase research and classroom space on ... technology for the study of health sciences, and will ... needs and interests of our students," said Shelley ...
(Date:7/31/2014)... 31, 2014  Cannabis Science, Inc. (OTC-QB: CBIS), ... development and related consulting, is pleased to announce ... of cannabis and European Union certified hemp varieties ... strains for development of proprietary formulations for clinical ... market for critical ailments such as cancer and ...
Breaking Medicine Technology:Cancer Network Highlights Methods Oncologists Can Use to Improve Communication 2Cancer Network Highlights Methods Oncologists Can Use to Improve Communication 3Touro University California Garners Grant From Long Foundation 2Cannabis Science Initiates Scientific Cultivation Programs to Test Multiple Strains of Cannabis to Obtain Extract Formulations for Clinical Drug Development Targeting Multiple Critical Ailments Starting with Cancer and Neurological Disorders 2
eValuator fixed-curve diagnostic electrophysiology catheters offer an effective balance between clinical performance and cost....
Wire mesh braided design with a platinum core....
... The St. Jude Medical® Pacing System Analyzer ... solution for implantation testing, programming and interrogation ... as an easy-to-use accessory to the St. ... testing by obtaining measurements of intrinsic P- ...
... The Libert Coronary Stent ... generation of lesion access ... flexibility, a low crossing ... delivery catheter, the performance ...
Medicine Products: