Navigation Links
New Screening Techniques to Lead Advances In Pain Therapy

To understand the effect of a particular mutant protein, whose individual amino acid residue has been, mutated it has to be passed through the ion channel protein// and examine the effect that these mutations have on the channel's function. But it is a very laborious process. Hence the new high-throughput screening methodology has come to our rescue which has the ability to analyze 14,000 mutants. The scientists have isolated five mutants that specifically affect menthol activity.

The results were published in the journal Nature Neuroscience. This new understanding could lead to potential advances in pain therapy. This new methodology can be used to study the activation mechanism of other drugs and proteins. Ardem Patapoutian, associate professor at Scripps Research, who directed the research, said that it is understood that our ability to sense temperature is closely linked to our ability to sense pain.

Hence if there is a misregulation of temperature-activated ion channels then it can result in chronic pain syndromes. Ion channels are proteins found in the cell membrane that can form a tunnel or channel that allows specific ions to move across the membrane. When activated, the channel opens, allowing an influx of calcium ions into the axon, an electrical signal that alerts the neuron, which relays the message to the brain.

Some of these ion channels are considered as targets to treat chronic inflammatory and neuropathic pain indications. The researchers identified the exact point at which the menthol interacted and the site that translates binding information to ion channel activity.

Research Associate Michael Bandell, said that this could prove to be useful as a general method to analyze the mechanism by which drugs can activate or inhibit ion channels or other receptors. Specifically, the new methodology could be used to identify amino acid residues in certain ion channel proteins and G-protein coupled receptors that are involved in the interaction with small molecules that affect their function.


'"/>




Related medicine news :

1. Screening device for ovarian cancer
2. Screening bypasses radical breast surgery
3. Screening of Lazy Eye
4. Screening Cost-Effective for Lung Cancer
5. Screening Newborns Questioned
6. Screening For Prostate Cancer in men over 75 Questioned
7. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
8. The Effectiveness Of Screening Tests Questioned
9. Screening Test For Early Diagnosis Of Colorectal Cancer
10. The Importance Of Skin Cancer Screening
11. Ovarian Cancer Screening Questioned
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/21/2017)... ... 2017 , ... Dudnyk has announced the launch of its new brand identity, ... potential of specialty and orphan brands can only be achieved when the needs and ... Effect is at the heart of a true partnership between our agency and our ...
(Date:4/21/2017)... ... April 21, 2017 , ... Crossover Symmetry , ... , an active lifestyle company that provides Human Performance Training and education to ... offers, first responders, military officers and others in service through the development and ...
(Date:4/21/2017)... UK (PRWEB) , ... April 21, 2017 , ... ... for Enterprise in the category of International Trade, the UK’s most prestigious award ... international trade, which represents 95% of total revenues and has grown by a ...
(Date:4/21/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, Texas, wrote an ... crisis with solution to peace plan. Yisrayl says war has never brought peace and he ... the Creator Himself. , Yisrayl says war drums are beating all over the media ...
(Date:4/21/2017)... ... 21, 2017 , ... Indiana Fiber Network, LLC (IFN), the ... to Tele-Media Solutions. IFN is delivering Multi-Gigabit data rates as an upstream ... protect transport with 3GB Dual Access Internet access now available in their service ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017 The Mobile X-Ray product segment is the ... during the forecast period Mobile X-Ray segment is ... mobile X-Ray devices market, which is estimated to be valued ... a CAGR of 7% over the forecast period. Mobile X-Ray ... than US$ 100 Mn in 2017 over 2016. The segment,s ...
(Date:4/19/2017)... NEW YORK , April 19, 2017 /PRNewswire/ ... This report on the prostate cancer ... of the global market. Increasing prevalence of prostate ... as innovation in the development of new drugs ... hormone-refractory prostate cancer drug due to lesser side ...
(Date:4/19/2017)... , April 19, 2017  Sorrento Therapeutics, ... antibody-centric, clinical-stage biopharmaceutical company developing new treatments for ... the closing of its previously announced underwritten public ... at a public offering price of $2.00 per ... estimated offering expenses payable by Sorrento.  The net ...
Breaking Medicine Technology: