Navigation Links
New Screening Techniques to Lead Advances In Pain Therapy

To understand the effect of a particular mutant protein, whose individual amino acid residue has been, mutated it has to be passed through the ion channel protein// and examine the effect that these mutations have on the channel's function. But it is a very laborious process. Hence the new high-throughput screening methodology has come to our rescue which has the ability to analyze 14,000 mutants. The scientists have isolated five mutants that specifically affect menthol activity.

The results were published in the journal Nature Neuroscience. This new understanding could lead to potential advances in pain therapy. This new methodology can be used to study the activation mechanism of other drugs and proteins. Ardem Patapoutian, associate professor at Scripps Research, who directed the research, said that it is understood that our ability to sense temperature is closely linked to our ability to sense pain.

Hence if there is a misregulation of temperature-activated ion channels then it can result in chronic pain syndromes. Ion channels are proteins found in the cell membrane that can form a tunnel or channel that allows specific ions to move across the membrane. When activated, the channel opens, allowing an influx of calcium ions into the axon, an electrical signal that alerts the neuron, which relays the message to the brain.

Some of these ion channels are considered as targets to treat chronic inflammatory and neuropathic pain indications. The researchers identified the exact point at which the menthol interacted and the site that translates binding information to ion channel activity.

Research Associate Michael Bandell, said that this could prove to be useful as a general method to analyze the mechanism by which drugs can activate or inhibit ion channels or other receptors. Specifically, the new methodology could be used to identify amino acid residues in certain ion channel proteins and G-protein coupled receptors that are involved in the interaction with small molecules that affect their function.


'"/>




Related medicine news :

1. Screening device for ovarian cancer
2. Screening bypasses radical breast surgery
3. Screening of Lazy Eye
4. Screening Cost-Effective for Lung Cancer
5. Screening Newborns Questioned
6. Screening For Prostate Cancer in men over 75 Questioned
7. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
8. The Effectiveness Of Screening Tests Questioned
9. Screening Test For Early Diagnosis Of Colorectal Cancer
10. The Importance Of Skin Cancer Screening
11. Ovarian Cancer Screening Questioned
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/10/2016)... ... February 10, 2016 , ... Ongoing news of the ravages of traumatic ... to conduct a survey that takes a closer look at cases of TBI being ... and causes of TBI among the aging population, and identifies the challenges associated with ...
(Date:2/10/2016)... ... February 10, 2016 , ... Armune BioScience signed ... their network of laboratory service centers across the country. Launched in April of 2015, ... the detection of prostate cancer. Apifiny order volume exceeded 3,000 tests in 2015. Primary ...
(Date:2/10/2016)... ... February 10, 2016 , ... The Club at ... the prestigious Distinguished Emerald Club of the World award, as determined by the ... of the most respected trade publications serving private clubs. , “We’d like to ...
(Date:2/10/2016)... ... 10, 2016 , ... Workrite Ergonomics, who is celebrating their 25th year of ... to being an internationally recognized leader in their industry. , "We are very proud ... President of Workrite. “Workrite recognized the importance of good ergonomics before most of ...
(Date:2/10/2016)... ... February 09, 2016 , ... Ross A. ... are delighted to welcome a new addition to their growing practice. Beginning this ... as a nurse practitioner performing cosmetic procedures including injectables, fillers and ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)...  Visage Imaging Inc. ("Visage"), a wholly owned ... that the American College of Radiology (ACR) and ... Visage 7 Enterprise Imaging Platform as the new ... SIMulation (SIM). SIM is the assessment component of ... multi-faceted and fully-integrated online assessment, education and remediation ...
(Date:2/10/2016)... -- CERS ), Medivation, Inc. (NASDAQ: MDVN ... Therapeutics, Inc. (NASDAQ: CLDX ). --> CERS ... (NASDAQ: ADMS ) and Celldex Therapeutics, Inc. (NASDAQ: ... become vitally important in the development of targeted treatment therapies ... which are defined as those intended for the safe and ...
(Date:2/10/2016)... Israel , February 10, 2016 /PRNewswire/ ... leader in the field of cartilage repair, announces the ... 5, 2016. The $15 million investment was led by ... pharmaceutical manufacturer, and was joined by existing Regentis investors ... and both the Technion Research & Development Foundation and ...
Breaking Medicine Technology: