Navigation Links
New Ribosome Finding Could Lead to Antiviral Therapies

The ribosome is the protein-producing nanomachine in cells that keeps the human body cranking along. A discovery by University of Maryland researchers// has provided a clue that could lead to programming the ribosome to fight viruses like HIV AIDS and SARS.

In the March 23 issue of the journal Molecular Cell, University of Maryland biology professor Jonathan Dinman and research assistant professor Artural Meskauskas describe how their discovery of the function of some long protein finger-like structures in the ribosome could lead to new antiviral therapies in the near future.

“One such finger, located in a ribosomal protein called L3, acts as a switch to help the ribosome coordinate all of its functions,” said Dinman. “We found that by altering this switch, the cell lost its ability to propagate viruses. If we could mimic this, we could target the L3 protein for antiviral therapies.”

Turning Off A Virus
The ribosome is a complex molecular machine that makes proteins, the molecular building blocks of our bodies. “I think of the ribosome as a nanomachine that coordinates events in a sequential order,” Dinman said. “The core of the ribosome is made up mostly of RNA, and this does most of the heavy lifting. But the outsides of ribosomes are also decorated with proteins, and these tend to have long tentacle-like structures that extend deep into ribosomal cores.”

According to Dinman and Meskauskas’ paper, previous studies have shown that L3 plays an important role in a number of cellular functions, including drug resistance and virus replication.

“The finger-like extensions of L3 may help coordinate ribosome-associated functions by acting as a switch or a gatekeeper,” Dinman said. “When you alter the L3 switch, you alter the way the ribosome coordinates all of the functions of the cell. We found that the cells with this L3 mutation could not reproduce viruses.

“These mutant forms of L3 also made cells resistant to certain antibiotics. Understanding how these mutants affect the interactions between ribosomes and factors that lead to drug resistance can provide the foundation for design of new antibacterials to counter resistance of pathogens to drugs,” said Dinman. “This study also provides a basis for deeper insight into design of small molecule antiviral therapies, hopefully in the near future.”

Source-ewswise
SRM
'"/>




Related medicine news :

1. Finding relief from Excruciating Headaches a challenge
2. Latest Findings On The Deadly Disease - SARS
3. New Findings Could Reduce The Extent Of Spinal Cord Injuries
4. Surprising Cystic Fibrosis Finding That Could Be A Helpful Treatment Option
5. New Findings for Repeated Miscarriages
6. Finding The Key To Weight Loss!
7. Internet Helps Patients In Finding Info About Their Childrens Health Conditions
8. How Healthy Are Herbal Products? US Findings.
9. Dispute in Findings about Radiation exposure
10. New Findings on Autism Research
11. Engineering Nutrient-Rich Plants Made For Feasible By New Findings
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... ... a legally blind and certified personal trainer is helping to develop a weight loss fitness ... to fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... ... , ... Those who have experienced traumatic events may suffer from a complex ... as drug or alcohol abuse, as a coping mechanism. To avoid this pain and ... a traumatic event. , Trauma sufferers tend to feel a range of emotions, from ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... 2016 - Forecast to 2022" report to their offering. ... up to date financial data derived from varied research sources ... with potential impact on the market during the next five ... comprises of sub markets, regional and country level analysis. The ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 ... Tomorrow,s Leaders Scholarship is any indication, the future is ... online at www.diabetesscholars.org by the Diabetes Scholars ... in the way of academic and community service excellence. ... program since 2012, and continues to advocate for people ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Volumes: Global Analysis (United States, China, Japan, Brazil, United ... to their offering. ... healthcare business planners, provides surgical procedure volume data in ... with an in-depth analysis of growth drivers and inhibitors, ...
Breaking Medicine Technology: