Navigation Links
New Ribosome Finding Could Lead to Antiviral Therapies

The ribosome is the protein-producing nanomachine in cells that keeps the human body cranking along. A discovery by University of Maryland researchers// has provided a clue that could lead to programming the ribosome to fight viruses like HIV AIDS and SARS.

In the March 23 issue of the journal Molecular Cell, University of Maryland biology professor Jonathan Dinman and research assistant professor Artural Meskauskas describe how their discovery of the function of some long protein finger-like structures in the ribosome could lead to new antiviral therapies in the near future.

“One such finger, located in a ribosomal protein called L3, acts as a switch to help the ribosome coordinate all of its functions,” said Dinman. “We found that by altering this switch, the cell lost its ability to propagate viruses. If we could mimic this, we could target the L3 protein for antiviral therapies.”

Turning Off A Virus
The ribosome is a complex molecular machine that makes proteins, the molecular building blocks of our bodies. “I think of the ribosome as a nanomachine that coordinates events in a sequential order,” Dinman said. “The core of the ribosome is made up mostly of RNA, and this does most of the heavy lifting. But the outsides of ribosomes are also decorated with proteins, and these tend to have long tentacle-like structures that extend deep into ribosomal cores.”

According to Dinman and Meskauskas’ paper, previous studies have shown that L3 plays an important role in a number of cellular functions, including drug resistance and virus replication.

“The finger-like extensions of L3 may help coordinate ribosome-associated functions by acting as a switch or a gatekeeper,” Dinman said. “When you alter the L3 switch, you alter the way the ribosome coordinates all of the functions of the cell. We found that the cells with this L3 mutation could not reproduce viruses.

“These mutant forms of L3 also made cells resistant to certain antibiotics. Understanding how these mutants affect the interactions between ribosomes and factors that lead to drug resistance can provide the foundation for design of new antibacterials to counter resistance of pathogens to drugs,” said Dinman. “This study also provides a basis for deeper insight into design of small molecule antiviral therapies, hopefully in the near future.”

Source-ewswise
SRM
'"/>




Related medicine news :

1. Finding relief from Excruciating Headaches a challenge
2. Latest Findings On The Deadly Disease - SARS
3. New Findings Could Reduce The Extent Of Spinal Cord Injuries
4. Surprising Cystic Fibrosis Finding That Could Be A Helpful Treatment Option
5. New Findings for Repeated Miscarriages
6. Finding The Key To Weight Loss!
7. Internet Helps Patients In Finding Info About Their Childrens Health Conditions
8. How Healthy Are Herbal Products? US Findings.
9. Dispute in Findings about Radiation exposure
10. New Findings on Autism Research
11. Engineering Nutrient-Rich Plants Made For Feasible By New Findings
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... ... HMP , a leader in healthcare events and education, today announced that ... ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie Awards luncheon ... editorial and design excellence across a range of sectors. This year’s program included the ...
(Date:10/12/2017)... ... 12, 2017 , ... On Saturday, October 21, the Health & Wellness Center ... to raise money for the American Heart Association Heart Walk. Teams of up to ... together to keep their treadmills moving for 5 hours. Treadmills will start at 7:00 ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations ... literacy software tool, and the Cancer Patient Education Network (CPEN), an independent professional ... announce a new strategic alliance. , As CPEN’s strategic partner, HLI will ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra ... care advancements to physician colleagues, skilled nursing facility medical directors and other clinicians ... Waters of Wound Care." , "At many of these conferences we get to ...
(Date:10/12/2017)... , ... October 12, 2017 ... ... life sciences content management, presents its enhanced Pepper Flow promotional review platform ... -18, 2017. Pepper Flow’s increased insight-driven capabilities help marketers streamline the medical, ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
(Date:9/19/2017)... 19, 2017   ZirMed Inc ., a recognized leader ... that it has been ranked #1 by its users for ... Rankings 2017 User Survey. ZirMed was recognized as the top-ranked ... and medical centers over 200 beds and holds one of ... user survey history. ...
(Date:9/12/2017)... MOUNTAIN LAKES, N.J. , Sept. 12, 2017  Consumer reviews ... Embrace Hearing as the number one company for hearing ... Oticon™, ReSound™ and fifteen other brands. ... Embrace Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that ...
Breaking Medicine Technology: