Navigation Links
New Ribosome Finding Could Lead to Antiviral Therapies

The ribosome is the protein-producing nanomachine in cells that keeps the human body cranking along. A discovery by University of Maryland researchers// has provided a clue that could lead to programming the ribosome to fight viruses like HIV AIDS and SARS.

In the March 23 issue of the journal Molecular Cell, University of Maryland biology professor Jonathan Dinman and research assistant professor Artural Meskauskas describe how their discovery of the function of some long protein finger-like structures in the ribosome could lead to new antiviral therapies in the near future.

“One such finger, located in a ribosomal protein called L3, acts as a switch to help the ribosome coordinate all of its functions,” said Dinman. “We found that by altering this switch, the cell lost its ability to propagate viruses. If we could mimic this, we could target the L3 protein for antiviral therapies.”

Turning Off A Virus
The ribosome is a complex molecular machine that makes proteins, the molecular building blocks of our bodies. “I think of the ribosome as a nanomachine that coordinates events in a sequential order,” Dinman said. “The core of the ribosome is made up mostly of RNA, and this does most of the heavy lifting. But the outsides of ribosomes are also decorated with proteins, and these tend to have long tentacle-like structures that extend deep into ribosomal cores.”

According to Dinman and Meskauskas’ paper, previous studies have shown that L3 plays an important role in a number of cellular functions, including drug resistance and virus replication.

“The finger-like extensions of L3 may help coordinate ribosome-associated functions by acting as a switch or a gatekeeper,” Dinman said. “When you alter the L3 switch, you alter the way the ribosome coordinates all of the functions of the cell. We found that the cells with this L3 mutation could not reproduce viruses.

“These mutant forms of L3 also made cells resistant to certain antibiotics. Understanding how these mutants affect the interactions between ribosomes and factors that lead to drug resistance can provide the foundation for design of new antibacterials to counter resistance of pathogens to drugs,” said Dinman. “This study also provides a basis for deeper insight into design of small molecule antiviral therapies, hopefully in the near future.”

Source-ewswise
SRM
'"/>




Related medicine news :

1. Finding relief from Excruciating Headaches a challenge
2. Latest Findings On The Deadly Disease - SARS
3. New Findings Could Reduce The Extent Of Spinal Cord Injuries
4. Surprising Cystic Fibrosis Finding That Could Be A Helpful Treatment Option
5. New Findings for Repeated Miscarriages
6. Finding The Key To Weight Loss!
7. Internet Helps Patients In Finding Info About Their Childrens Health Conditions
8. How Healthy Are Herbal Products? US Findings.
9. Dispute in Findings about Radiation exposure
10. New Findings on Autism Research
11. Engineering Nutrient-Rich Plants Made For Feasible By New Findings
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing skills ... patients and their families pay tribute to a genetic counselor by nominating him or ... Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome magazine ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
(Date:6/23/2016)... RIDGE, Ill. and INDIANAPOLIS ... of students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship ... The 2016 scholarship winners, announced today online at ... to let type 1 diabetes stand in the way ... Diabetes has supported the Foundation,s scholarship program since 2012, ...
(Date:6/23/2016)... 23, 2016 Revolutionary technology includes ... Oticon , industry leaders in advanced audiology and hearing ... Oticon Opn ™, the world,s first internet connected hearing ... IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... number of ,world firsts,: , TwinLink™ - ...
Breaking Medicine Technology: