Navigation Links
New Research Offers Hope In Kidney FailureTreatment

An analysis of how two different proteins interact with one another to enable self destruction of kidney cells when there is an reduced oxygen supply// to the tissue may eventually pave way for improved treatment modalities to manage ischemic renal failure.

Such self-destruction of the kidney can be activated during dehydration, low blood pressure, injury to the kidney, removal of kidney during kidney transplantation and septic shock, all of which result in a temporary reduction or halt of blood and oxygen supply.

Ischemia, or reduced oxygen supply can trigger apopotosis or programmed cell death, more specifically in the tubular cells of the kidney that consume most of the energy. Ischemic kidney failure has been associated with a 50% mortality. Despite improvements in the medical field, it has not been possible to reduce this mortality rate associated with the disease, over the years.

Tubular cells are loaded with the task of reabsorbtion of nearly 50 gallons of fluid, in addition to substances such as salt and glucose, in a short span of 24 hours. These cells, therefore consume a high amount of energy and are highly susceptible to apoptosis and injury. In a oxygen starved state, two killer proteins termed Bid and Bax get activated and establish a partnership to induce cell death. This system is highly active in the kidney.

A $1 million grant has been sanctioned by the National Institute of Diabetes & Digestive & Kidney Diseases to the research group to better understand the role of these proteins in causing ischemic renal failure.

While it is known that during ischemic renal injury, the protein Bid is cleaved, followed by release of active fragments. It is not exactly known what causes the protein to cleave and move from its usual place outside the cell to mitochondria which is loacted inside the cell membrane. Cleavage of Bid yields a truncated Bid product (tBid) that may interact with Bax to produce a change in the protein structure.

This may further failitate the movemet of the Bax protein inside the mitochondria. Once inside, the protein can inhibit the respiratory function of the mitochondria, which is the main source of oxygen to the cells. The researchers believe that Bid and Bax exibit a synergistic activity to promote apoptosis or cell death. Without Bid, there is less apoptosis while kidney function and survival rates significantly improve. In addition, there is also an enhanced cell regeneration, paving way for ischemic recovery.

The researchers are currently studing the effect of kidney damage caused by Cisplatin, an anti-cancer agent used in the treatment of ovarian, testicular, small cell lung cancer and head and neck tumors. With our improved understanding of such concepts, we might perhaps have an improved treatment modality for ischemic renal failure and perhaps cancer by accelarating self-destruction.

'We want to see how the drug can kill kidney cells and if we can find a protective mechanism to prevent kidney cell death without stopping cancer cell death,' says Dr. Dong, one of the senoir researchers involved in the study.


'"/>




Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Researchers urge caution in using ear tube surgery
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Research of Ritalin
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. A Compilation of recent Diabetes Research articles
9. Research on causes for falling helps develop preventive strategies
10. New standards for Human Research Safety
11. Research on Celiac Disease in children
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda ... orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including ... accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. ...
(Date:6/24/2016)... ... , ... People across the U.S. are sharpening their pencils and honing their ... in which patients and their families pay tribute to a genetic counselor by nominating ... of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... OTTAWA, Ontario , June 27, 2016  VMS ... the Company,s Board will take whatever measures required to ... the Company,s stock which is currently listed on the ... S Wexler, Company Chairman and CEO, "We are seeing ... be difficult to understand, not only by the Company, ...
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
Breaking Medicine Technology: