Navigation Links
New Research May Be Useful for Developing Drugs for HIV and Cancer

Researchers of Virginia Commonwealth University Massey Cancer Center have discovered a process of restraining a set of proteins, using small molecules containing platinum, which causes HIV and cancer. //

The breakthrough will be beneficial for the researchers to develop new drugs to fight HIV or cancer by selectively targeting proteins known as zinc fingers.

In the May 30 issue of the journal Chemistry & Biology, researchers reported that a zinc finger protein, known as HIV NCp7, can be inhibited when it is exposed to a platinum complex. They observed that when the HIV NCp7 protein interacts with platinum, the zinc portion of the molecule is ejected from the protein chain. This causes the protein to lose its tertiary structure or overall shape. For these molecules, shape is an important property that enables the protein to carry out certain biological functions.

The process, active site displacement, involved design of a platinum drug with higher affinity for the protein peptide backbone, thus eliminating the zinc from its active site.

In the specific case discussed in the paper, the HIV NCp7 protein is responsible for the proliferation of the HIV virus. If researchers can inhibit the action of this zinc finger protein, they can stop the spread of the virus.

'When we target specific viruses with drugs, over time patients can become resistant to treatment and the drug becomes ineffective. Therefore, novel biological processes and proteins are attractive targets for antiviral drug development,' said lead author Nicholas Farrell, Ph.D., professor and chair in the Department of Chemistry at VCU and a member scientist with the VCU Massey Cancer Center.

According to Farrell, these study findings may also one day be applied to the selective targeting of zinc fingers involved in the biological processes responsible for the spread of cancer. By applying the concept to development of anticancer drugs, th
'"/>




Page: 1 2

Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Researchers urge caution in using ear tube surgery
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Research of Ritalin
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. A Compilation of recent Diabetes Research articles
9. Research on causes for falling helps develop preventive strategies
10. New standards for Human Research Safety
11. Research on Celiac Disease in children
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Research May Useful for Developing Drugs for HIV and Cancer

(Date:9/21/2014)... 2014 "I wanted to be able ... consume sugary, foul-tasting energy drinks," said an inventor from ... want to drink plain, old coffee. That is why ... He developed ENERG CHEWING GUM to provide a healthy ... The formula contains nutritious vitamins, minerals and antioxidants. It ...
(Date:9/21/2014)... 2014 "I want to help people ... but haven’t the money for chiropractors," said an inventor ... such a product for myself." , The Stretch is ... the thigh muscles and align the spine properly. It ... discomfort of pinched nerves. Compact and easy to use, ...
(Date:9/21/2014)... Best Cheap Hosting USA, one of the ... and GreenGeeks are the best Reseller hosting suppliers in ... hosting supplier. Actually, these companies have outperformed their competitors ... People can get the best web hosting at affordable ... to the manager, reseller hosting is a very popular ...
(Date:9/21/2014)... 2014 To accommodate the ever-growing customer ... provide more trendy items. Recently, the company has unveiled ... the new and elegant wedding gowns, Angeldress.co.uk wants to ... need in an easy way. Its high quality vintage ... from 12% off to 62% off. , Online shopping ...
(Date:9/21/2014)... (PRWEB) September 21, 2014 “Cluster headaches ... so intense and difficult to resolve,” said Steve Young ... can't think of a pain that is more intense.” ... suffers from cluster headaches, or migraines, that medical research ... the serotonin system,” he added. , Serotonin (5-HT, 5-hydroxytryptamine) ...
Breaking Medicine News(10 mins):Health News:Best Cheap Hosting USA Announces The Best Reseller Hosting Suppliers In 2014 2Health News:Angeldress.co.uk Launches New Range Of 2014 Vintage Wedding Dresses In Its Online Store 2Health News:Homeostasis: Equinox Serotonin (5HT) Headache Stories ~ New on the Bryan William Brickner Blog 2
... ... ... , ... , ...
... ... ... , ... ...
... , ... ... ... ...
... ... ... ... ...
... choking off blood supply to the brain, every minute counts: ... left untreated, making it a race to recognize symptoms so ... Americans 135 million people -- are more than an ... best equipped to care for them if they are stricken ...
... neutrons are poised to play a big role in ... The reason: They are the focus of a process ... the chemistry of a wide range of important materials, ... article in Chemical & Engineering News (C&EN), ...
Cached Medicine News:Health News:Restaurants, C-Stores and Retailers Defy the Challenging Economy Raising A Record $5.6 Million During Annual St. Jude Halloween Promotion 2Health News:Restaurants, C-Stores and Retailers Defy the Challenging Economy Raising A Record $5.6 Million During Annual St. Jude Halloween Promotion 3Health News:Restaurants, C-Stores and Retailers Defy the Challenging Economy Raising A Record $5.6 Million During Annual St. Jude Halloween Promotion 4Health News:Restaurants, C-Stores and Retailers Defy the Challenging Economy Raising A Record $5.6 Million During Annual St. Jude Halloween Promotion 5Health News:Restaurants, C-Stores and Retailers Defy the Challenging Economy Raising A Record $5.6 Million During Annual St. Jude Halloween Promotion 6Health News:New Ankle Arthritis Treatments Help Boomers Stay Active 2Health News:New Ankle Arthritis Treatments Help Boomers Stay Active 3Health News:New Ankle Arthritis Treatments Help Boomers Stay Active 4Health News:The 32nd Annual Los Angeles Chinatown Firecracker 5K/10K Run, Bike Ride, and Nite 'N Day Festival Celebrates the Year of the Tiger This Weekend 2Health News:The 32nd Annual Los Angeles Chinatown Firecracker 5K/10K Run, Bike Ride, and Nite 'N Day Festival Celebrates the Year of the Tiger This Weekend 3Health News:The 32nd Annual Los Angeles Chinatown Firecracker 5K/10K Run, Bike Ride, and Nite 'N Day Festival Celebrates the Year of the Tiger This Weekend 4Health News:The 32nd Annual Los Angeles Chinatown Firecracker 5K/10K Run, Bike Ride, and Nite 'N Day Festival Celebrates the Year of the Tiger This Weekend 5Health News:The 32nd Annual Los Angeles Chinatown Firecracker 5K/10K Run, Bike Ride, and Nite 'N Day Festival Celebrates the Year of the Tiger This Weekend 6Health News:The 32nd Annual Los Angeles Chinatown Firecracker 5K/10K Run, Bike Ride, and Nite 'N Day Festival Celebrates the Year of the Tiger This Weekend 7Health News:The 32nd Annual Los Angeles Chinatown Firecracker 5K/10K Run, Bike Ride, and Nite 'N Day Festival Celebrates the Year of the Tiger This Weekend 8Health News:The 32nd Annual Los Angeles Chinatown Firecracker 5K/10K Run, Bike Ride, and Nite 'N Day Festival Celebrates the Year of the Tiger This Weekend 9Health News:SeqWright Advances Genomic Discovery With Isilon IQ 2Health News:SeqWright Advances Genomic Discovery With Isilon IQ 3Health News:SeqWright Advances Genomic Discovery With Isilon IQ 4Health News:SeqWright Advances Genomic Discovery With Isilon IQ 5Health News:SeqWright Advances Genomic Discovery With Isilon IQ 6Health News:SeqWright Advances Genomic Discovery With Isilon IQ 7Health News:Half of Americans live more than an hour away from lifesaving stroke care 2Health News:Half of Americans live more than an hour away from lifesaving stroke care 3
(Date:9/19/2014)... DALLAS , September 19, 2014 ... Market by Equipment Type (Benchtop, Mobile, Industrial, & ... Others), Technology (Tray-style, Manifold, & Rotary) & Geography ... by MarketsandMarkets, defines and segments the lyophilization market ... regions with analyses and projections of the market ...
(Date:9/19/2014)... ORLANDO, Fla. , Sept. 19, 2014  The ... grow, with the publication of two papers this past ... Otolaryngology – Head and Neck Surgery , finds ... objective and subjective measures of sleep disordered breathing, leading ... the reduction in obstructive sleep apnea severity and improvement ...
(Date:9/19/2014)... and CAMBRIDGE, Mass. , ... Inc. (PGDx), a provider of advanced cancer genome ... , a leader in discovering and developing highly ... disclosed the first-ever comprehensive genomic study of malignant ... cancer of the female reproductive system, also known ...
Breaking Medicine Technology:Lyophilization Market Worth $5,121.5 Million by 2019 2Lyophilization Market Worth $5,121.5 Million by 2019 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 2First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 3First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 4
... 14, 2011 /PRNewswire-iReach/ -- Hope Paige Designs, ... newest product today. The THUMBAND, a silicone band worn ... a slogan reminding the wearer to text safely. ... of texting while driving have been well documented. Studies ...
... Mass., April 14, 2011 Millstone Medical Outsourcing announced ... marketing capacity in an effort to broaden existing relationships ... device industry and in other markets.  Jeff Barton was ... Coogan will serve as Marketing Coordinator.  Millstone, outsource partner ...
Cached Medicine Technology:More Dangerous Than Drunk Driving, Hope Paige Designs Promotes a THUMBAND for Safe Texting 2Millstone Medical Outsourcing Expands Sales, Marketing Capacity, Hires Two Professionals 2
... the advance of digital imaging technology, ... towards digital formats, allowing for easier ... advance in digital pathology imaging is ... in radiology, and which is continuing ...
Inquire...
PRINCIPLE: The QC-SLIDES™ are specifically designed microscope slides intended to be part of the quality control program to monitor microbiological stains and staining techniques....
Each slide contains a gram positive control of Staphylococcus aureus ATCC ® 25923 and a gram negative control of Escherichia coli ATCC ® 25922....
Medicine Products: