Navigation Links
New Platform for Regulating Expression of Therapeutic Genes Unveiled

A new platform for regulating the expression of therapeutic genes, which will have major implications for gene and cell therapy, was presented today at the 10th Annual Meeting of the American Society of Gene Therapy (ASGT) in Seattle.

Carefully regulating gene expression is crucial to the success of gene and cell therapy. For many applications, gene transfer is being employed to engineer cells for therapeutic factor production, expansion, selection of a desired cell type and even fail-safe suicide. These applications often require precise regulation in order to ensure gene expression in the correct tissue and prevent it in unwanted cell types.

Now, a team of scientists led by Dr. Luigi Naldini at the San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET) in Milan have developed a new platform. Dr. Naldini and colleagues provided a striking demonstration that their new design can enable delivered genes to become highly responsive to a cells identity. This is particularly relevant for the emerging field of stem cell gene therapy, in which genes are delivered into a cell that can give rise to many distinct cell types.

To achieve their goal, the TIGET scientists came up with a strategy to take advantage of a recently discovered network of gene regulation mediated by small RNA molecules, known as microRNA.

MicroRNAs downregulate the expression of specific genes in cells where the gene is not needed, and thereby have an important influence over the identity of the cell. More than 350 mammalian microRNAs have been identified, with many being present only in some specific tissues and cell types.

Dr. Naldinis group showed that the addition of microRNA binding sites into their gene delivery vectors results in gene regulation dictated by the cells own cognate microRNA. Simply put, they could engineer their gene to be turned off in cells where the microRNA is present. As a proof-of-principle, the resea
'"/>




Page: 1 2

Related medicine news :

1. Lovers Latest Hang Outs – Railway Platform
2. Substance P May Pre-empt VIP in Regulating Temperature
3. Controlled Gene Expressions Can Cure Many Diseases
4. Genetic Expressions Can Influence The Process Of Aging
5. Non-Coding RNA Vital For Gene Activation And Protein Expression
6. Protein Expression to Serve as Marker for Head and Neck Cancer
7. Innocent Expression of Compassion, Children Draw For HIV kids
8. New Diagnostic Tool Uncovered Gene Expression Patterns in Recessive Genetic Disorders
9. Facial Expressions are Inherited: Study
10. Telomerase Expression Linked To Body Mass
11. How Blood Flow Dictates Gene Expression
Post Your Comments:
(Date:10/20/2014)... OH (PRWEB) October 20, 2014 ... Assisted Living Center on Oct. 14. The $11 million ... and services, and a cooked-to-order kitchen with full-service restaurant ... Akron’s premier choice for first class Assisted Living apartments,” ... “Our residents deserve the highest quality of care and ...
(Date:10/20/2014)... National Teen Driver Safety Week is October 19-25, 2014 ... (Ohio AAP, http://www.ohioaap.org ) is joining the National Highway ... to talk to their teens and always set the rules ... the leading cause of death for U.S. teens. In 2012, ... 859 (42%) of those teen drivers were killed in crashes. ...
(Date:10/20/2014)... It’s hard to imagine what it’s like to live ... the world, it’s a reality. And while new shoes are ... to walk barefoot on rocky terrain or sewage-lined streets just ... friends. , Buckner International's Shoes for Orphan Souls ... October to encourage support for Air1 and while also providing ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Do you ... interventions? Here comes a wonderful app Metassessor for teachers, ... development company helped its client “Intervention Development LLC” ... The app is designed for iOS 4.3 or later ... This app is optimized for iPhone 5. It is ...
(Date:10/19/2014)... Recently, BambooIndustry.com, one of the most popular suppliers of ... bamboo deckings . Moreover, the company has launched a ... available at deeply discounted rates. , As is ... the significance of online business nowadays. Thus, BambooIndustry.com pays ... workers are striving to deliver both value and efficiency ...
Breaking Medicine News(10 mins):Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Ohio AAP Promotes National Teen Driver Safety Week 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3Health News:High Quality Bamboo Deckings, New Items Unveiled By BambooIndustry.com 2
... prizes of $1 million each for outstanding achievement, announced the ... who donate 10% of their prize money towards 20 Tel ... a ceremony on May 19, 2008, at Tel Aviv University ... Israel, Mr. Shimon Peres. , Accepting the award, Vice President ...
... Minn., Feb. 26 Acuo Technologies, a market,leading ... imaging,industry for archiving, collaboration and migration services, is ... for Imaging,(XDS-I) solution, One of the most ... to,share clinical content. Healthcare IT solutions today must ...
... eWorld Companies, Inc.,(Pink Sheets: EWRL) announced today that ... a long-term strategic alliance with,the Hemophilia Foundation of ... eWorld and HFSC will engage in a series ... advertise,HFSC and its events and activities on its ...
... FRANCISCO, Feb. 26 VIA Pharmaceuticals,Inc. (Nasdaq: VIAP ... for the treatment of cardiovascular disease, announced today that,James ... VIA,will present a company update at the Susquehanna Second ... at 1:30 p.m. ET at the W,Hotel in New ...
... Inc.,(OTC Bulletin Board: EMED), a leading provider of ... healthcare industry,has signed a distribution agreement with Southwood ... product line of MedCom USA.,MedCom,s products offer real-time ... include Credit/Debit, Easy Pay and Check,Guarantee/EFT all delivered ...
... N.J., Feb. 26 You know that the ... young women. Is there a,theoretical basis for exploring ... HPV Vaccination" a 3-part CME Webcast, assesses this,and ... is an online,offering from Sexuality, Reproduction and Menopause ...
Cached Medicine News:Health News:Al Gore, Tom Stoppard and Amos Oz Are 2008 Dan David Prize winners 2Health News:Al Gore, Tom Stoppard and Amos Oz Are 2008 Dan David Prize winners 3Health News:Acuo Technologies(R) Announces a Fully Integrated XDS-I Solution 2Health News:eWorld Companies, Inc. Establishes Strategic Alliance With Hemophilia Foundation of Southern California 2Health News:eWorld Companies, Inc. Establishes Strategic Alliance With Hemophilia Foundation of Southern California 3Health News:MedCom USA Signs Southwood Medical Marketing to Distribute MedCom System 2Health News:MedCom USA Signs Southwood Medical Marketing to Distribute MedCom System 3Health News:MedCom USA Signs Southwood Medical Marketing to Distribute MedCom System 4Health News:Experts Delve Into Issues of HPV Vaccination 2
(Date:10/19/2014)... 2014  Henry Schein, Inc. (NASDAQ: HSIC ... and services to office-based dental, animal health and medical ... Dental Supply, Inc., a leading full-service provider of dental ... Schein,s entrance into Japan , the ... to 28 the number of countries in which the ...
(Date:10/17/2014)... 2014  Training market researchers to spot and ... in today,s highly competitive global marketplace. As resources ... effectively and efficiently produce high performing analysts, regardless ... Effective training programs can help these ... internal clients by developing analysts who can drive ...
(Date:10/17/2014)... 2014 ... the addition of the  "China Interventional Cardiovascular ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... China impacted by accelerated ... concept, dietary habit, way of working and ...
Breaking Medicine Technology:Henry Schein Enters Japan With Investment in Iwase Dental Supply 2Henry Schein Enters Japan With Investment in Iwase Dental Supply 3Henry Schein Enters Japan With Investment in Iwase Dental Supply 4Henry Schein Enters Japan With Investment in Iwase Dental Supply 5Effective Training Programs for Market Research Groups can Boost Overall Organizational Success 2China Interventional Cardiovascular Device Industry Report 2014-2017 2China Interventional Cardiovascular Device Industry Report 2014-2017 3
It is available in a 5cc-balloon version with round tip and two opposing eyes, and a 30cc-balloon version with two staggered eyes. BARDEX Silicone-Elastomer Foley Catheters are also available in kits...
All-silicone construction provides maximum softness and biocompatibility for enhanced patient comfort. Supplied sterile in peel-open packages. Intended for one-time use....
The BARDEX I.C. Catheter represents Bard's newest technology in providing protection against NUTI....
Used to provide bladder drainage by percutaneous placement of a Malecot catheter. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: