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New Non-toxic Therapies for Breast, Ovarian Cancers

on. The researchers now believe the mechanism applies to difficult-to-treat invasive breast and ovarian cancers.

"We’re now tapping into what causes the characteristic cell shape changes seen in cancerous tumours and possibly how these cells grow and metastasize. It gives us a whole new target for therapy," says Assoc. Prof. of Medical Genetics and stem cell expert Kelly McNagny, co-senior principal investigator. "If we can block the protein, we may be able to stop the spread of cells."

Post-doctoral Fellow Julie Nielsen, of UBC’s Biomedical Research Centre, and PhD student Marcia Graves of the Dept. of Cellular and Physical Sciences, were instrumental in designing and executing the research experiments, he adds.

Next steps involve advancing the research in animal models, designing antibodies to block the function of the protein and working with the UBC-based Centre for Drug Research and Development to identify new therapies to combat metastasizing cancer.

The researchers say information from this discovery may speed development of new therapies to within 10 years.

In 2006, more than 22,000 women were diagnosed with breast cancer and 5,300 died of it, according to estimates from the Canadian Breast Cancer Foundation. The Canadian Cancer Society estimates that approximately 2,300 new cases of ovarian cancer were diagnosed and about 1,600 women died from the disease in 2006.



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