UT Southwestern Medical Center is participating in a nationwide study investigating //whether modified combinations of vitamins, minerals and fish oil products can slow the progression of vision loss from age-related macular degeneration.

“This study will evaluate nutrient-based factors that may influence the development and progression of the two most prevalent age-related eye diseases, age-related macular degeneration and cataracts,” said Dr. Yu-Guang He, an ophthalmologist and principal investigator of the study at UT Southwestern.

The Age-Related Eye Disease Study 2, sponsored by the National Institutes of Health, will build upon results from an earlier study that found high-dose antioxidant vitamins and minerals taken orally reduced the risk of AMD progression by 25 percent and the risk of moderate vision loss by 19 percent. That study involved vitamins C and E, beta carotene, zinc and copper.

The new study will examine whether adding lutein and zeaxanthin (derived from plants) and omega-3 fatty acids DHA and EPA (derived from fish oil) decreases progression to advanced AMD, which often leads to vision loss. It will also consider the effect these supplements have on cataract and moderate vision loss.

“Everybody talks about the potential benefit of these supplements, but there’s no solid evidence for that, no clinical evidence so far,” said Dr. He, associate professor of ophthalmology and director of the Retina Fellowship Program. “This study is going to try to resolve that.”

About 4,000 people between the ages of 50 and 85 with AMD in both eyes or advanced AMD in one eye, will be assessed at nearly 100 institutions over the next five years.

Age-related macular degeneration, or AMD, is the leading cause of vision loss in the United States for people over age 60. Nearly 2 million Americans have lost vision due to advanced AMD and another 7 million are at risk for losing vision.

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