Navigation Links
New Mouse Model to Aid in Cancer-causing Genes Hunt

Scientists has developed a more human-like mouse model of cancer they say will aid the search for cancer-causing genes and improve the predictive value of laboratory drug testing.

The study was conducted by a team of researchers including Richard Maser, Ronald A. DePinho, Lynda Chin at the Dana-Farber Cancer Institute.

Conventional mouse models are developed by transferring a cancer-causing oncogene into a mouse embryo.

"You plug it into the mouse, and lo and behold, it gets cancer. But that's rigging the game -- it's not identical to the process by which tumors normally arise," Maser said.

These tumors dont have some important characteristics of human tumors, such as genomic instability, pieces of chromosomes breaking apart and reattaching, which lead to defects like missing genes or extra copies of genes some of which are key to the tumors formation.

As part of the study, researchers used gene knockouts to develop mice whose cells dont have molecules which guard the genome from instability in the DNA.

Researchers created mice which formed T-cell acute lymphoblastic leukemia/lymphoma, or T-ALL, and the cancer cells showed rampant genome instability resulting in intricate pattern of mutations, chromosomal rearrangements, gene amplifications and gene deletions similar to those in human solid tumors.

Researchers characterized these mouse tumors by performing high-resolution array-CGH profiling, a genome-scanning technology that can define regions of DNA abnormalities.

Researchers then compared the patterns of chromosomal changes in the mice with patterns observed in more than 400 human tumor specimens, including melanoma, lung, colon, and pancreatic cancers, and multiple myeloma.

They found that genetic instability in the mouse cancer cells resulted in DNA alterations that were identical to similar changes in human tumors in many cases. Thi s similarity suggested that the new mouse model might be useful in steering the search for genes that are crucial for cancer growth.

The mouse model's close resemblance to human T-ALL made it possible for the scientists to identify two genes, FBXW7 and PTEN, to be commonly deleted or mutated in this type of human cancer.

"We found a rather striking overlap of genetic alterations in the mouse and human cancers, which should greatly help us sort out genetic events that drive cancers from those that are simply irrelevant 'passenger' events," DePinho said.

Researchers concluded that the over lining patterns of genetic abnormalities in mouse and human tumors showed that cancer mechanisms in the two species are more alike than earlier thought.

The findings of the study were published online in the journal Nature.


Related medicine news :

1. Mouse Allergen Found In Homes Could Trigger Asthma In Kids
2. Researchers Develop Mouse Model Of Brain Tumor
3. German Scientists Create Stem Cells From Mouse Testes
4. Mouse Models To Determine The Cause Of Aggressive Leukemia
5. Mouse Model Beneficial to Study of Head and Neck Cancer
6. Scientists Discover New RNAs in Mouse Testicles
7. Scientists Isolate Leukemia Stem Cells in Mouse Model
8. Mouse Model Demonstrates Immune System Reaction In Chlamydia Infection
9. Mouse Gene With Gene Stutter Will Help Leukemia Research
10. Rett Syndrome Reversed in Genetic Mouse Model
11. Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
Post Your Comments:

(Date:10/13/2017)... Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD ... dose required and providing a CBD form that can be easily incorporated into liquid ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
(Date:10/12/2017)... ... ... Planet Fitness, one of the largest and fastest growing franchisors and operators ... location in Covington, LA at 401 N. U.S. Highway 190, in January of 2018. ... in the Holiday Square shopping center. Its location allows it to serve both Covington ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... delivery system that we intend to develop to enable prevention of a major ... to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Divoti USA will engrave and process all non-coated ... latest FDA requirements, which stipulates new criteria regarding medical device manufacture ... Medical ID jewelry such as Medical ID Bracelets, can rest assured ... of the new FDA requirements . ... Divoti offers this dark mark fiber laser engraving process ...
(Date:10/11/2017)... 2017  Caris Life Sciences ® , a leading ... of precision medicine, today announced that St. Jude Medical ... Alliance™ (POA) as its 17 th member. Through ... Crosson Cancer Institute will help develop standards of care ... profiling, making cancer treatment more precise and effective. ...
(Date:10/10/2017)... 10, 2017  NDS received FDA 510(k) clearance in May 2017 ... display stand specifically designed for endoscopy environments. An innovative secondary monitor ... clinical solution to support the improvement of patient outcomes, procedural efficiency, ... ... ...
Breaking Medicine Technology: