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New Mouse Model to Aid in Cancer-causing Genes Hunt

Scientists has developed a more human-like mouse model of cancer they say will aid the search for cancer-causing genes and improve the predictive value of laboratory drug testing.

The study was conducted by a team of researchers including Richard Maser, Ronald A. DePinho, Lynda Chin at the Dana-Farber Cancer Institute.

Conventional mouse models are developed by transferring a cancer-causing oncogene into a mouse embryo.

"You plug it into the mouse, and lo and behold, it gets cancer. But that's rigging the game -- it's not identical to the process by which tumors normally arise," Maser said.

These tumors dont have some important characteristics of human tumors, such as genomic instability, pieces of chromosomes breaking apart and reattaching, which lead to defects like missing genes or extra copies of genes some of which are key to the tumors formation.

As part of the study, researchers used gene knockouts to develop mice whose cells dont have molecules which guard the genome from instability in the DNA.

Researchers created mice which formed T-cell acute lymphoblastic leukemia/lymphoma, or T-ALL, and the cancer cells showed rampant genome instability resulting in intricate pattern of mutations, chromosomal rearrangements, gene amplifications and gene deletions similar to those in human solid tumors.

Researchers characterized these mouse tumors by performing high-resolution array-CGH profiling, a genome-scanning technology that can define regions of DNA abnormalities.

Researchers then compared the patterns of chromosomal changes in the mice with patterns observed in more than 400 human tumor specimens, including melanoma, lung, colon, and pancreatic cancers, and multiple myeloma.

They found that genetic instability in the mouse cancer cells resulted in DNA alterations that were identical to similar changes in human tumors in many cases. Thi s similarity suggested that the new mouse model might be useful in steering the search for genes that are crucial for cancer growth.

The mouse model's close resemblance to human T-ALL made it possible for the scientists to identify two genes, FBXW7 and PTEN, to be commonly deleted or mutated in this type of human cancer.

"We found a rather striking overlap of genetic alterations in the mouse and human cancers, which should greatly help us sort out genetic events that drive cancers from those that are simply irrelevant 'passenger' events," DePinho said.

Researchers concluded that the over lining patterns of genetic abnormalities in mouse and human tumors showed that cancer mechanisms in the two species are more alike than earlier thought.

The findings of the study were published online in the journal Nature.


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