Navigation Links
New Mouse Model to Aid in Cancer-causing Genes Hunt

Scientists has developed a more human-like mouse model of cancer they say will aid the search for cancer-causing genes and improve the predictive value of laboratory drug testing.

The study was conducted by a team of researchers including Richard Maser, Ronald A. DePinho, Lynda Chin at the Dana-Farber Cancer Institute.

Conventional mouse models are developed by transferring a cancer-causing oncogene into a mouse embryo.

"You plug it into the mouse, and lo and behold, it gets cancer. But that's rigging the game -- it's not identical to the process by which tumors normally arise," Maser said.

These tumors dont have some important characteristics of human tumors, such as genomic instability, pieces of chromosomes breaking apart and reattaching, which lead to defects like missing genes or extra copies of genes some of which are key to the tumors formation.

As part of the study, researchers used gene knockouts to develop mice whose cells dont have molecules which guard the genome from instability in the DNA.

Researchers created mice which formed T-cell acute lymphoblastic leukemia/lymphoma, or T-ALL, and the cancer cells showed rampant genome instability resulting in intricate pattern of mutations, chromosomal rearrangements, gene amplifications and gene deletions similar to those in human solid tumors.

Researchers characterized these mouse tumors by performing high-resolution array-CGH profiling, a genome-scanning technology that can define regions of DNA abnormalities.

Researchers then compared the patterns of chromosomal changes in the mice with patterns observed in more than 400 human tumor specimens, including melanoma, lung, colon, and pancreatic cancers, and multiple myeloma.

They found that genetic instability in the mouse cancer cells resulted in DNA alterations that were identical to similar changes in human tumors in many cases. Thi
'"/>




Page: 1 2

Related medicine news :

1. Mouse Allergen Found In Homes Could Trigger Asthma In Kids
2. Researchers Develop Mouse Model Of Brain Tumor
3. German Scientists Create Stem Cells From Mouse Testes
4. Mouse Models To Determine The Cause Of Aggressive Leukemia
5. Mouse Model Beneficial to Study of Head and Neck Cancer
6. Scientists Discover New RNAs in Mouse Testicles
7. Scientists Isolate Leukemia Stem Cells in Mouse Model
8. Mouse Model Demonstrates Immune System Reaction In Chlamydia Infection
9. Mouse Gene With Gene Stutter Will Help Leukemia Research
10. Rett Syndrome Reversed in Genetic Mouse Model
11. Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Mouse Model Aid Cancer causing Genes Hunt

(Date:7/30/2015)... ... July 30, 2015 , ... Eyepartner is proud ... in San Diego, California’s Gaslamp Quarter Plaza for five years this September. , ... monitor the area for any suspicious activity. These cameras are in place to ...
(Date:7/30/2015)... ... July 30, 2015 , ... " DevExpress ” ... a look at small, medium, and large businesses making an impact in their ... business review and shared with viewers how DevExpress has provided software development tools ...
(Date:7/30/2015)... ... July 30, 2015 , ... The Beryl ... Scholar Program. In partnership with Patient Experience Institute, these offerings reinforce the commitment ... the front lines and throughout the experience movement, and provide information and research ...
(Date:7/30/2015)... , ... July 30, 2015 , ... ... today that the latest issue of Inclusive™ magazine, its multimedia publication focused on ... digital edition of the new issue, Volume 6, Issue 2, as well as ...
(Date:7/30/2015)... ... July 30, 2015 , ... Between 2012 and 2014 HIV ... Health News Florida on June 17th. Those untreated heroin use disorders share their ... the spread of dirty needles throughout the community. Ultimately Florida’s HIV infection rates have ...
Breaking Medicine News(10 mins):Health News:Eyepartner Software Helps Victims in Gaslamp Quarter Plaza 2Health News:Eyepartner Software Helps Victims in Gaslamp Quarter Plaza 3Health News:Software to Develop High-Performance Data-Driven Apps was Featured on NewsWatch Television 2Health News:The Beryl Institute Opens Applications for 2015 Patient Experience Grant and Scholar Programs 2Health News:The Beryl Institute Opens Applications for 2015 Patient Experience Grant and Scholar Programs 3Health News:Glidewell Laboratories Puts Out Latest Issue of Dental Implant Magazine Inclusive™ 2Health News:Glidewell Laboratories Puts Out Latest Issue of Dental Implant Magazine Inclusive™ 3Health News:Glidewell Laboratories Puts Out Latest Issue of Dental Implant Magazine Inclusive™ 4Health News:HIV Rates Rise in S. Florida, Harbor Village Comments on Health News Florida's Recent Article 2Health News:HIV Rates Rise in S. Florida, Harbor Village Comments on Health News Florida's Recent Article 3
... The naturally high levels of leptin in diabetic patients ... treat heart blockages, but using a chemical that differs ... counteract this effect. , The work by researchers at ... diabetics who get stents, they say. Though drug-eluting stents ...
... Pheromone,Sciences, Inc. (OTC Bulletin Board: EROX) ("HPS" or "the ... with the U.S. Patent and,Trademark Office for the use ... in sea coral, which has significant emotional impacts,on both ... well-being and social attraction. , ...
... United Health Foundation announced its commitment to American Indian ... Indian Country by donating $45,000 for nine $5,000 scholarships ... support of Arizona students pursuing careers in the health ... scholarship recipients were chosen based on their academic achievement, ...
... SACRAMENTO, Calif., Dec. 17 Sutter Health has announced,the ... general,counsel. She will assume her new role January 5, ... , Formerly senior ... Eisenbeis, LLP (HRDE) for the past two decades, DiBenedetto,served ...
... Hospital have answered a central question in cancer biology: ... Stem cells are immature cells that can renew themselves ... the range of body tissues. In recent years, researchers ... forms of stem cells. , Like a brand-name ...
... Combines ZEISS,s Precision Progressive Lenses and Transitions® Lenses to Produce Optimal ... ... 17, 2008 -- Two of the most distinguished names in the ... leading-edge eyewear., , ,Carl Zeiss Vision, a leader for 160 years ...
Cached Medicine News:Health News:HPS Files Patent for Mood-Enhancing Compound Naturally Found in Sea Coral 2Health News:United Health Foundation Provides $45,000 for Scholarships to the American Indian College Fund for Arizona Healthcare Students 2Health News:United Health Foundation Provides $45,000 for Scholarships to the American Indian College Fund for Arizona Healthcare Students 3Health News:Sutter Health Welcomes New General Counsel 2Health News:Molecular marker identifies normal stem cells as intestinal tumor source 2Health News:Carl Zeiss Vision and Transitions Optical Inc. Promote Pioneering Eyewear to Consumers 2
(Date:7/30/2015)... 2015  Growth of the U.S. nonprescription market is ... prescription users to the OTC market. Due to an ... Rx-to-OTC switch activity over the next five years with ... new brands entering the market into existing categories. ... years (even those with low to moderate likelihood), the ...
(Date:7/30/2015)... 30, 2015  Medimetriks Pharmaceuticals, Inc. announced today ... III clinical study for Ozenoxacin, a novel bactericidal ... the exclusive U.S. rights to Ozenoxacin 1% cream.  ... 44 centers with an emphasis on U.S. patients, ... months and older with a clinical diagnosis of ...
(Date:7/30/2015)... 2015 Vermillion, Inc. (VRML), a ... announced today it will report its second ... close on Thursday, August 13, 2015, followed ... at 4:30pm Eastern.Conference Call and Webcast:  ... Pacific  Domestic: , 888-430-8691International: ...
Breaking Medicine Technology:Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 2Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 3
... up to 10 inches/ 25 cm thinner than other ... Allegra X-22 Series is the space-saving multipurpose solution for ... / 46 cm wide • 11 Rotor Library • ... ways to Spin 1.5 mL & PCR+ Tubes: ...
... is up to 10 inches/ 25 cm thinner than ... the Allegra X-22 Series is the space-saving multipurpose solution ... inches / 46 cm wide • 11 Rotor Library ... different ways to Spin 1.5 mL & PCR+ Tubes: ...
... centrifuges offer high-volume versatility along with a ... them ideal for a wide variety of ... Four- or six-place sealed swinging bucket rotor, ... offered , Lare capacity (4 x 750 ...
... Multipurpose high performance centrifuge designed to accommodate ... devices is refrigerated for heat labile samples. ... include refrigerated capability with automatic quick cooling ... < 7 min, no maintenance brushless motor, ...
Medicine Products: