Navigation Links
New Mouse Model to Aid in Cancer-causing Genes Hunt

Scientists has developed a more human-like mouse model of cancer they say will aid the search for cancer-causing genes and improve the predictive value of laboratory drug testing.

The study was conducted by a team of researchers including Richard Maser, Ronald A. DePinho, Lynda Chin at the Dana-Farber Cancer Institute.

Conventional mouse models are developed by transferring a cancer-causing oncogene into a mouse embryo.

"You plug it into the mouse, and lo and behold, it gets cancer. But that's rigging the game -- it's not identical to the process by which tumors normally arise," Maser said.

These tumors dont have some important characteristics of human tumors, such as genomic instability, pieces of chromosomes breaking apart and reattaching, which lead to defects like missing genes or extra copies of genes some of which are key to the tumors formation.

As part of the study, researchers used gene knockouts to develop mice whose cells dont have molecules which guard the genome from instability in the DNA.

Researchers created mice which formed T-cell acute lymphoblastic leukemia/lymphoma, or T-ALL, and the cancer cells showed rampant genome instability resulting in intricate pattern of mutations, chromosomal rearrangements, gene amplifications and gene deletions similar to those in human solid tumors.

Researchers characterized these mouse tumors by performing high-resolution array-CGH profiling, a genome-scanning technology that can define regions of DNA abnormalities.

Researchers then compared the patterns of chromosomal changes in the mice with patterns observed in more than 400 human tumor specimens, including melanoma, lung, colon, and pancreatic cancers, and multiple myeloma.

They found that genetic instability in the mouse cancer cells resulted in DNA alterations that were identical to similar changes in human tumors in many cases. Thi s similarity suggested that the new mouse model might be useful in steering the search for genes that are crucial for cancer growth.

The mouse model's close resemblance to human T-ALL made it possible for the scientists to identify two genes, FBXW7 and PTEN, to be commonly deleted or mutated in this type of human cancer.

"We found a rather striking overlap of genetic alterations in the mouse and human cancers, which should greatly help us sort out genetic events that drive cancers from those that are simply irrelevant 'passenger' events," DePinho said.

Researchers concluded that the over lining patterns of genetic abnormalities in mouse and human tumors showed that cancer mechanisms in the two species are more alike than earlier thought.

The findings of the study were published online in the journal Nature.


'"/>




Related medicine news :

1. Mouse Allergen Found In Homes Could Trigger Asthma In Kids
2. Researchers Develop Mouse Model Of Brain Tumor
3. German Scientists Create Stem Cells From Mouse Testes
4. Mouse Models To Determine The Cause Of Aggressive Leukemia
5. Mouse Model Beneficial to Study of Head and Neck Cancer
6. Scientists Discover New RNAs in Mouse Testicles
7. Scientists Isolate Leukemia Stem Cells in Mouse Model
8. Mouse Model Demonstrates Immune System Reaction In Chlamydia Infection
9. Mouse Gene With Gene Stutter Will Help Leukemia Research
10. Rett Syndrome Reversed in Genetic Mouse Model
11. Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... Cincinnati, OH (PRWEB) , ... December 08, 2016 ... ... offering insurance and financial planning services from offices headquartered in Hamilton County, is ... animal rescue LuvFurMutts. , LuvFurMutts specializes in finding new homes for orphaned or ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... offices that serve communities in and around the greater Phoenix metropolitan region, is ... Youth Connection. , The mission of the Homeless Youth Connection is to promote ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Compretta Insurance Agency, a family owned insurance ... around the Hancock County area, is announcing the launch of a charity effort aimed ... Hancock County Food Pantry has worked for more than 30 years to meet the ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... to families and business owners in and around central Kansas, is joining the ... at-risk youth in the region. , Headquartered in Wichita, Youth Horizons works to ...
(Date:12/7/2016)... ... 07, 2016 , ... Students attending Envision’s summer 2017 ... get hands-on experience in an emergency medical simulation, When Care is Hours Away. ... real-life medical skills that are critical success in a future career and beyond. ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... A Small Business Innovative Research (SBIR) grant ... (NIH) to Phoenix -based NeuroEM Therapeutics, ... grant will seek to determine an optimal set of ... waves to treat Alzheimer,s Disease. The grant will also ... treat other neurologic disorders such as Parkinson,s Disease and ...
(Date:12/8/2016)... -- Economic growth in the United States will continue in ... in their December 2016 Semiannual Economic Forecast. Expectations are ... in mid-2009, as indicated in the monthly ISM ® ... manufacturing sector is optimistic about growth in 2017, with ... the non-manufacturing sector indicates that 14 of its industries ...
(Date:12/8/2016)... LOS ANGELES , Dec. 8, 2016 /PRNewswire/ ... and manufacturing of dissolution testing and diffusion testing ... has been acquired by Teledyne Instruments, Inc. ("Teledyne"). ... Hanson,s long-proven line of precision testing instruments, as ... while accelerating development of new products and services. ...
Breaking Medicine Technology: