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New Molecular Treatment Identified To Treat Blood Cell Cancers

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These antibodies have drawbacks, however: They bind to healthy lymphocytes along with malignant ones; in addition, they do not bind to T cells and therefore can't be used to treat T-cell lymphoma. In contrast, LLP2A binds to both B-cell and T-cell lymphoid cancer lines, and has low affinity for normal T or B lymphocytes. It also has lower uptake in the liver and spleen than the monoclonal antibodies now on the market for lymphoma treatment. ‘We believe LLP2A may be an ideal vehicle for the delivery of radionuclides, cytotoxic agents, toxins, cytokines and nanoparticles to lymphoid cancers which include non-Hodgkin's lymphoma and acute lymphocytic leukemia,’ Lam said.

In their paper, Lam and his colleagues report that they have already used LLP2A to successfully image lymphoid tumors in living mice. The researchers coupled near-infrared fluorescent dyes to LLP2A peptides; when the dye-tagged peptides found and locked onto a tumor, the tumor became visible to a near-infrared scanner. LLP2A was identified using a combinatorial chemistry method Lam developed more than a decade ago. Known as the ‘one-bead-one-compound’ method, Lam's technique allows scientists to synthesize millions of novel compounds in less than a week and analyze them in a few days.

(Source: Eurealert)
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