Navigation Links
New Model for understanding Tumor Metastasis

Researchers from Children's Memorial Research Center, Northwestern University have found a new model that shows how tumor cells interacts with the surrounding normal skin cells in the presence of microenvironment of tumor cells. // The process of metastasis spread and transformation from normal skin cell to malignant cell is understood with the help of this new model.

"Our findings offer new insights into the influence of the tumor cell microenvironment on the transformation of normal skin cells, as well as on genetic triggering mechanisms and signaling pathways that could be targeted for novel therapeutic strategies to inhibit the spread of melanoma," Hendrix said.

Metastatic cancer cells are characterized by increased tumor cell invasion and migration, as well as an undifferentiated, or "plastic," nature.

The Hendrix lab has hypothesized that this poorly differentiated cell type serves as an advantage to aggressive cancer cells by enhancing their ability to metastasize virtually undetected by the immune system. The group's current study tested the hypothesis that the microenvironment of metastatic melanoma cells could induce benign skin cells to become cancer-like.

The researchers seeded a particularly aggressive form of human metastatic melanoma cells onto a three-dimensional collagen matrix and allowed the cells to precondition the microenvironment for several days. The malignant melanoma cells were removed and the matrix was left intact.

Then, normal human skin cells were seeded onto the melanoma-preconditioned matrix and were allowed to remain for several days.

After this period, the previously normal cells seeded onto the matrix preconditioned by the metastatic melanoma were reprogrammed to express genes (produce specific gene proteins) associated with a highly plastic cell type similar to the aggressive melanoma cells used in the study.

Removal of the "transdifferentiated" sk
'"/>




Page: 1 2

Related medicine news :

1. Researchers Develop Mouse Model Of Brain Tumor
2. Mathematical Model Can Now Help Predict Asthma Risk
3. Model Kate Moss - Re-Birth After Humiliation
4. Womens Self-Esteem Not Lowered By Seeing Ultra Thin Models
5. India Can Become A Role Model In Combating HIV Infections
6. Mouse Models To Determine The Cause Of Aggressive Leukemia
7. Aussie Model Macpherson Hated Tall Figure
8. Mouse Model Beneficial to Study of Head and Neck Cancer
9. Tamil Nadu Emerging As Model State In Public Health Care: Governor
10. iSTART Brain Model Reveals the possible Cause of Autism
11. Scientists Isolate Leukemia Stem Cells in Mouse Model
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Model for understanding Tumor Metastasis

(Date:7/31/2015)... New York (PRWEB) , ... July 31, 2015 , ... ... strut their stuff, Super-Sod debuted their new type of sod called Leisure Time(TM) ... trademark application in process. , To commemorate introduction of this new type of sod, ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... Ticket Down ... is currently going on in Chicago at Grant Park. The festival will end ... of North America to Chicago for the annual Lollapalooza. This unique and unbelievably ...
(Date:7/31/2015)... ... 31, 2015 , ... Last week, the Mesothelioma Applied Research ... be accessed by visiting http://www.curemeso.org/store . , “Our new store features a ... whenever a product is purchased, the Meso Foundation receives a $5.00 donation,” said ...
(Date:7/31/2015)... ... July 31, 2015 , ... There’s no better way to ... it comes time to cook the next meal, making July the most appropriate to ... best grilling tips and recipes. , Make the next cookout different than the ones ...
(Date:7/31/2015)... ... 31, 2015 , ... Coco Libre announced today that their flagship Organic Coconut ... 2015 Vans US Open of Surfing, July 25 through August 2 in Huntington Beach, ... on the market, is a natural choice given the Open’s commitment to sustainable practices. ...
Breaking Medicine News(10 mins):Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3Health News:Coco Libre Brings Eco-conscious Hydration to Vans US Open of Surfing 2
... With More than 1,000 Reported Incidents, Caregivers Call ... SAN FRANCISCO, Aug. 31 Home care workers ... organization seeking to decertify the workers, union, saying they had been ... The home caregivers, members of the Service Employees International Union, ...
... ... claim, but has now reversed decision and will cover patient,s life flight , ... Scottsdale, AZ (PRWEB) August 31, 2009 -- ... life flight transportation to be evaluated for a liver transplant. Her doctors told ...
... , SAN FRANCISCO, Aug. 31 /PRNewswire/ ... agency staffed with seasoned marketing professionals and a division of Omnicom,s ... to the position of Director of Strategy for their growing healthcare ... to ECI CEO and President Bara Oscodar. , , ...
... , , LAKE FOREST, ... the world leader in generic injectable pharmaceuticals, today announced that the ... for six new presentations of therapeutic heparin in single- and multiple-dose ... clot formation in central venous catheters and for anticoagulant (blood thinning) ...
... , SCOTTSDALE, Ariz., Aug. 31 Last year, ... of life flight transportation to be evaluated for ... evaluation in order to get on the transplant list. Travel by ground ... Her health insurance company told her they would not cover the ...
... , , , , ... San Diego-based MultiGEN Diagnostics Inc. has launched a novel multi-target DNA ... testing in molecular diagnostics. , , "Until now, ... diagnostic market, forcing laboratories to adopt number of alternative methods such ...
Cached Medicine News:Health News:San Francisco Home Care Workers Describe Lies, Coercion, and Fraud in Union Signature Drive 2Health News:San Francisco Home Care Workers Describe Lies, Coercion, and Fraud in Union Signature Drive 3Health News:In Final Hour Prior to Litigation, Angel MedFlight's Air Ambulance Team Overturns Decision by Major Insurance Company 2Health News:In Final Hour Prior to Litigation, Angel MedFlight's Air Ambulance Team Overturns Decision by Major Insurance Company 3Health News:ECI Hires Robin Raff as Director of Strategy 2Health News:Hospira Receives FDA Approval for Six New Presentations of Heparin 2Health News:In Final Hour Prior to Litigation, Angel MedFlight's Air Ambulance Team Overturns Decision by Major Insurance Company 2Health News:In Final Hour Prior to Litigation, Angel MedFlight's Air Ambulance Team Overturns Decision by Major Insurance Company 3Health News:Cost Effective Solution for Patient Testing: Introducing Comprehensive and Affordable Molecular Diagnosis With Verifiable Accuracy 2
(Date:7/31/2015)... NEW YORK , July 31, 2015  Seeger Weiss ... Drug Administration (FDA) issued a warning letter to C.R. Bard, ... for not taking adequate strides to correct violations the agency ... aware of these violations after the FDA cited them during ... 05, 2015, in Bard,s Tempe, AZ , ...
(Date:7/31/2015)... 2015 Today, the National Association of ... issued a report urging greater accountability by the ... against websites illegally selling medications online. As detailed ... Program Progress Report for State and Federal Regulators: ... websites illegally distribute medications and avoid retribution. Such ...
(Date:7/31/2015)... , July 31, 2015 The ... press release on July 28, 2015, "Surviving Your ... Launches Fundraising for Patient Safety." A ... sentence should read: "PPAHS is a ... Patients on Opioids. For more information on the National ...
Breaking Medicine Technology:Seeger Weiss LLP Reports That The FDA Has Issued A Warning Letter To IVC Filter Manufacturer, C.R. Bard 2Seeger Weiss LLP Reports That The FDA Has Issued A Warning Letter To IVC Filter Manufacturer, C.R. Bard 3NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 2NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 3
... 3, 2012  Omeros Corporation (NASDAQ: OMER ) ... interact with each of four additional orphan G protein-coupled ... GPCRs, developing drugs targeting those receptors is extremely difficult. ... 45 percent of the Class A orphan GPCRs. There ...
... 2012 /PRNewswire-Asia/ -- Johnson & Johnson (China) ... Guangzhou Bioseal Biotechnology Co., Ltd. (Bioseal) a ... design, development and commercialization of a porcine ... surgery. The acquisition was completed after obtaining ...
Cached Medicine Technology:Omeros Adds Four More Unlocked Orphan GPCRs to its Portfolio 2Omeros Adds Four More Unlocked Orphan GPCRs to its Portfolio 3Omeros Adds Four More Unlocked Orphan GPCRs to its Portfolio 4Johnson & Johnson (China) Investment Ltd. Acquires Guangzhou Bioseal Biotechnology Co., Ltd. 2
Low-profile, hand-held instrument....
Developed in conjunction with Pierce E. Scranton, Jr., M.D., the Seattle Small Joint Arthroscopy Set offers meticulously designed instrumentation for elbow, foot, and ankle surgeries....
Developed in conjunction with Pierce E. Scranton, Jr., M.D., the Seattle Small Joint Arthroscopy Set offers meticulously designed instrumentation for elbow, foot, and ankle surgeries....
... The Small Fragment Plate and Screw System provides ... wide range on angular deformities; particularly the opening ... hallux valgus correction). The Small Fragment Plate and ... with a removable caddy that houses the plates, ...
Medicine Products: