Navigation Links
New Microchip for Protein Sorting

f good laboratory tools with which to prepare biological samples to analyze proteins, said Han, who also has affiliations in MIT's RLE, Computational and Systems Biology Initiative, Center for Materials Science and Engineering and Microsystems Technology Laboratories.

"I shifted my attention from DNA into the area of protein separation around 2002 with the shift to proteomics (the study of proteins)," Han said. "But the field was using decades-old gel electrophoresis technology. There is a big gap in the need for technology in this area."

Han and Fu therefore devised the anisotropic sieve that is embedded into a silicon chip. A biological sample containing different proteins is placed in a sample reservoir above the chip. The sample is then run through the sieve of the chip continuously. The chip is designed with a network of microfluidic channels surrounding the sieve, and the anisotropy (directional property) in the sieve causes proteins of different sizes to follow distinct migration trajectories, leading to efficient continuous-flow separation. The current sieve has an array of nanofluidic filters of about 55 nanometers, or billionths of a meter, wide.

"The proteins to be sorted are forced to take two orthogonal paths. Each path is engineered with different sieving characters. When proteins of different sizes are injected into the sieve under applied electric fields, they will separate into different streams based on size," Han explained. At the bottom of the chip the separated proteins are collected in individual chambers. Scientists then can test the proteins.

While other scientists have used similar continuous flow techniques to separate large molecules like long DNA, the MIT team succeeded with the tinier proteins. "This is the first time physiologically relevant molecules like proteins have been separated in such a manner," said Han. "We can separate the molecules in about a minute with the current device versus hours
'"/>




Page: 1 2 3

Related medicine news :

1. Microchip gives blind a chance of sight
2. Microchip gives blind a chance of sight
3. Lean Protein Could Be Key to Obesity Drugs
4. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
5. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
6. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
7. Protein in urine foresees heart disease
8. Levels Of Blood Proteins May Help Heart Disease Care
9. Protein signals need for heart surgery
10. Protein and fat improve memory
11. Clotting Protein plays a role in nerve repair
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Microchip for Protein Sorting

(Date:6/30/2015)... ... 30, 2015 , ... The U.S. Women's National Soccer Team will face the Costa Rica ... be on Sunday, August 16th at Heinz Field in Pittsburgh at 1:30 p.m. local time. ... Stadium in Chattanooga, TN. , The USA WNT previously played at Heinz Field in Pittsburgh ...
(Date:6/30/2015)... ... , ... CCAR is pleased to announce its expansion of recovery coaching services ... This month, staff member Jim Higgins left his role as Hartford Recovery Community ... take on this role of organizing peer recovery support available through CCAR’s volunteer coaches, ...
(Date:6/30/2015)... ... June 30, 2015 , ... America’s oldest cancer center ... to cancer prevention, screening and care for the people of Nigeria. Roswell Park ... will see Roswell Park faculty providing clinical consultations to assist LCC oncologists, who ...
(Date:6/30/2015)... ... 30, 2015 , ... Independence Day weekend is more than just fireworks to ... off of July as National Hot Dog Month. Americans are expected to eat more ... of the year and enough to stretch from Washington D.C. to Los Angeles more ...
(Date:6/30/2015)... ... ... After more than five years of research and development that includes active ... formulated for the unique skin of all people of color — is now available. ... to help protect the skin of all people of color this July Fourth holiday ...
Breaking Medicine News(10 mins):Health News:USA vs. Costa Rica Tickets at Heinz Field in Pittsburgh and Finley Stadium in Chattanooga: Ticket Down Slashes Presale Ticket Prices for Costa Rica vs. USA WNT 2Health News:The Connecticut Community for Addiction Recovery takes Recovery Coaching to a new level 2Health News:Intercontinental Oncology Partnership Brings Access to Specialized Cancer Care to Nigeria 2Health News:Intercontinental Oncology Partnership Brings Access to Specialized Cancer Care to Nigeria 3Health News:Intercontinental Oncology Partnership Brings Access to Specialized Cancer Care to Nigeria 4Health News:Intercontinental Oncology Partnership Brings Access to Specialized Cancer Care to Nigeria 5Health News:Biggest Hot Dog Weekend of the Year to Kick Off National Hot Dog Month 2Health News:GlobalSun – The First Sunscreen Developed for All People of Color – Hits The Market 2
... cause infections that typically target the digestive tract or bowel; ... could result. Enterococcus also can invade the bloodstream, ... the heart valve. Typically the only people who become ill ... have health issues, such as diabetes or chronic kidney failure. ...
... Jenifer Goodwin HealthDay Reporter , WEDNESDAY, Nov. 16 ... at heightened risk for stroke, a new study suggests. ... the Nurses, Health Study and about 28,000 men from the ... 26 years. Over that time, both men and women ...
... found that flu strains migrate back and forth between different ... contrary to the common belief that flu strains from the ... The research appeared online on Nov. 14 in the ... supported in part by the Centers of Excellence for ...
... imaging (MRI) to evaluate cardiovascular risk in World Trade ... of Medicine have found that the responders who experienced ... on September 11, 2001, demonstrate high-risk features of atherosclerosis ... American Heart Association,s Scientific Sessions 2011 in Orlando, Florida. ...
... Medicine have identified hepcidin, a hormone that regulates iron ... treating atherosclerosis. Suppressing hepcidin is a way to ... found in arterial plaques. Reducing iron levels pushes those ... called "reverse cholesterol transport," interfering with atherosclerosis, researchers have ...
... HealthDay Reporter , TUESDAY, Nov. 15 (HealthDay News) -- First ... following the New York City terror attacks on Sept. 11, ... Those Ground Zero workers who got there first may ... who came on the scene after Sept. 13, and may be ...
Cached Medicine News:Health News:Wayne State University to study novel treatment for antibiotic-resistant bacteria 2Health News:Blood Type May Be Associated With Stroke Risk: Study 2Health News:NIH grantees rebut theory that seasonal flu strains originate in tropical regions 2Health News:NIH grantees rebut theory that seasonal flu strains originate in tropical regions 3Health News:WTC workers exposed earlier to dust cloud have higher risk of atherosclerotic lesions 2Health News:Hormone that controls iron levels may be target for atherosclerosis treatment 2Health News:9/11 First Responders May Face Greater Heart Risks 2Health News:9/11 First Responders May Face Greater Heart Risks 3
(Date:6/30/2015)... June 30, 2015 Nortek Security & ... NTK ) and a leader in the residential ... announced it acquired mobile personal emergency response system ... Numera, Inc. Headquartered in ... implemented, mobile PERS products and cloud-based software platforms ...
(Date:6/30/2015)... 2015   Millar, Inc. , a leader in ... 2016 retirement of Craig Thummel , President/CEO and ... of service to the Company. The Company also announced ... of the Executive Management team as his successors. The ... currently Director of Sales and Marketing, as President, and ...
(Date:6/30/2015)... , June 24, 2015 ... announced the addition of the "Global Array ... The global array instruments market to ... the period 2014-2019 The global array instruments ... microarrays, protein microarrays, and others including tissue microarrays ...
Breaking Medicine Technology:Nortek Security & Control Acquires Health and Wellness Technology Business from Numera 2Nortek Security & Control Acquires Health and Wellness Technology Business from Numera 3Nortek Security & Control Acquires Health and Wellness Technology Business from Numera 4Millar, Inc. Announces Leadership Changes 2Millar, Inc. Announces Leadership Changes 3Global Array Instruments Market 2015-2019 - Advances in Personalized Medicines with Affymetrix, Agilent Technologies & Illumina Dominating 2
... Jan. 27, 2011 /PRNewswire-Asia/ -- China Sky One ... Company") (Nasdaq: CSKI ), a leading ... of China ("PRC"), today announced that Heilongjiang Tianlong ... subsidiary, was named a "Top Ten Branded Company ...
... Cetero Research, the leading early-stage contract research organization ... industry milestone with the completion of its 20,000th ... as the unmatched leader in early-phase clinical development ... therapeutic expertise that Cetero offers to pharmaceutical, biotechnology ...
Cached Medicine Technology:China Sky One Medical Receives Medical Industry Awards 2China Sky One Medical Receives Medical Industry Awards 3Cetero Research Announces Completion of 20,000th Early-Phase Clinical Study 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: