Navigation Links
New Method May Treat Brain Injuries

An injury to the brain can be devastating. When brain cells die, whether from head trauma, stroke or disease,// a substance called glutamate floods the surrounding areas, overloading the cells in its path and setting off a chain reaction that damages whole swathes of tissue.

Glutamate is always present in the brain, where it carries nerve impulses across the gaps between cells. But when this chemical is released by damaged or dying brain cells, the result is a flood that overexcites nearby cells and kills them.

A new method for ridding the brain of excess glutamate has been developed at the Weizmann Institute of Science. This method takes a completely new approach to the problem, compared with previous attempts based on drugs that must enter the brain to prevent the deleterious action of glutamate. Many drugs, however, can’t cross the blood-brain barrier into the brain, while other promising treatments have proved ineffective in clinical trials. Prof. Vivian Teichberg, of the Institute’s Neurobiology Department, working together with Prof. Yoram Shapira and Dr. Alexander Zlotnik of the Soroka Medical Center and Ben Gurion University of the Negev, has shown that in rats, an enzyme in the blood can be activated to “mop up” toxic glutamate spills in the brain and prevent much of the damage. This method may soon be entering clinical trials to see if it can do the same for humans.

Though the brain has its own means of recycling glutamate, injury causes the system to malfunction, leading to glutamate build up. Prof. Teichberg reasoned that this problem could be circumvented by passing glutamate from the fluid surrounding brain cells into the bloodstream. But first, he had to have a clear understanding of the mechanism for moving glutamate from the brain to the blood. Glutamate concentrations are several times higher in the blood than in the brain, and the body must be able to pump the chemical “upstream.” Glutamate pumps, called tran sporters, are found on the outsides of blood vessels, on cells that come into contact with the brain. These collect glutamate, creating small zones of high concentration from which the glutamate can then be released into the bloodstream.

Basic chemistry told him that he could affect the transporter activity by tweaking glutamate levels in the blood. When blood levels are low, the greater difference in concentrations causes the brain to release more glutamate into the bloodstream. He uses an enzyme called GOT that is normally present in blood to bind glutamate chemically and inactivate it, effectively lowering levels in the blood and kicking transporter activity into high gear. In their experiments, Teichberg and his colleagues used this method to scavenge blood glutamate in rats with simulated traumatic brain injury. They found that glutamate cleared out of the animals’ brains effectively, and damage was prevented.

Yeda, the technology transfer arm of the Weizmann Institute, now holds a patent for this method, and a new company based on this patent, called “Braintact Ltd.,” has been set up in Kiryat Shmona in northern Israel and is currently operating within the framework of Meytav Technological Incubator. The US FDA has assured the company of a fast track to approval. If all goes well, Phase I clinical trials are planned for the near future.

The method could potentially be used to treat such acute brain insults as head traumas and stroke, and prevent brain and nerve damage from bacterial meningitis or nerve gas. It may also have an impact on chronic diseases such as glaucoma, amyotrophic lateral sclerosis (ALS) or HIV dementia. Teichberg: “Our method may work where others have failed, because rather than temporarily blocking the glutamate’s toxic action with drugs inside the brain, it clears the chemical away from the brain into the blood, where it can’t do harm anymore.”

Source-Newwise
SRM
'"/>




Related medicine news :

1. Methods to have a flat stomach
2. Easier Methods Required to Screen Insulin Resistance
3. Easier Methods Required to Screen Insulin Resistance
4. Accuracy of Some Natural Family Planning Methods Questioned .
5. New Method Of Delivering Chemotherapy
6. Adopting Easier Methods To Screen Insulin Resistance
7. Diagnosing Sleep Apnea By Overnight Sleep Testing Method
8. New Screening Method Found To Detect Testicular Cancer In Its Initial Stages
9. A Novel Method For Measuring Interstitial Fluid Pressure In Cancer Tissues
10. A Novel Method Of Detection Of High Nuclear Grade Localized Renal Cell Carcinoma
11. New Method To Identify Protein Hot spots
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/17/2017)... ... ... make New Year’s resolutions or renew their commitment to better health with the start of ... want to kick off 2017 with better smiles. Dr. Mondavi is offering several promotions for ... , , A new patient package for just $49, which can ...
(Date:1/17/2017)... , ... January 17, 2017 , ... ... and the Montclair State University’s Athletic Training Education program forged a relationship built ... Training Education Program, which is consists of both student members and certified ...
(Date:1/16/2017)... Creek, MI (PRWEB) , ... January 17, 2017 , ... ... abuse located in Southwest Michigan, joined other volunteers and organizations in support of the ... hundreds of children and families dressed up in colorful costumes of all designs coming ...
(Date:1/16/2017)... ... January 16, 2017 , ... Gym Source, America’s leading retailer of premium residential ... Hanover, New Jersey. , “We are elated to be opening this new showroom,” explains ... designed to give clients a seamless and motivating shopping experience.” , Every fitness journey ...
(Date:1/16/2017)... ... January 16, 2017 , ... With the Grand Opening Event planned ... for use by sports teams and the general public. Built in five months by ... also be converted into basketball or pickleball courts. The space is also suitable for ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... Jan. 17, 2017 Secretary of Health Dr. ... Secretary Gary Tennis are warning Pennsylvanians of ... recent overdose deaths from the drug in ... intended to sedate large animals and is not meant ... comes into contact with it," Secretary Murphy said. "It,s ...
(Date:1/17/2017)... -- Paragon Bioservices received a multiple-award, indefinite-delivery, indefinite-quantity ... a variety of National Institute of Allergy ... activities. The IDIQ mechanism will allow Paragon to ... awards up to $159 million. Paragon ... development of biopharmaceuticals, is one of four awardees ...
(Date:1/17/2017)... Ariz. , Jan. 17, 2017 Angel ... US Navy Capt. Mark Kelly as the ... 2017 National Conference in Washington D.C. ... commander, will speak on Friday morning, April 21 at ... professionals from across the country are expected to attend ...
Breaking Medicine Technology: