Navigation Links
New Method For Fighting Leukemia

Researchers at Virginia Commonwealth University's Massey Cancer Center have created a new method for fighting Leukemia.

This new method improves the antileukemic activity of a novel agent that triggers programmed cell death, //a development that could lead to more effective strategies for fighting leukemia and other malignancies.

The cell death process, or apoptosis, is characteristically impaired in cancer cells. The process is regulated by a large family of proteins that either promotes or inhibits cell death. Recently, considerable attention has focused on the development of agents that inhibit the actions of antiapoptotic members of this family.

One such agent, known as ABT-737, potently blocks the pro-survival effects of two proteins, Bcl-2 and Bcl-xL, according to Steven Grant, M.D., Massey's associate director for translational research and co-leader of the cancer center's cancer cell biology program. Grant is senior author of the study, which is published in the Jan. 15 issue of the journal Cancer Research.

In laboratory experiments, ABT-737 has been shown to be very effective in killing tumor cells. However, this agent is unable to block the actions of another anti-apoptotic family member, Mcl-1, and it has been found that increased expression of Mcl-1 in tumor cells significantly reduces the anti-tumor effectiveness of ABT-737.

Grant and colleagues demonstrated that interventions that reduce levels of Mcl-1 in leukemia cells dramatically increase the effectiveness of ABT-737. Specifically, they employed an agent called roscovitine to block the synthesis of Mcl-1 at the RNA level. Grant said that because Mcl-1 is a very short-lived protein, disrupting its synthesis rapidly lowers Mcl-1 levels.

Grant's team found that the simultaneous reduction in Mcl-1 expression in conjunction with disruption of the anti-apoptotic actions of Bcl-2 and Bcl-xL by ABT-737 resulted in the marked activati
'"/>




Page: 1 2

Related medicine news :

1. Methods to have a flat stomach
2. Easier Methods Required to Screen Insulin Resistance
3. Easier Methods Required to Screen Insulin Resistance
4. Accuracy of Some Natural Family Planning Methods Questioned .
5. New Method Of Delivering Chemotherapy
6. Adopting Easier Methods To Screen Insulin Resistance
7. Diagnosing Sleep Apnea By Overnight Sleep Testing Method
8. New Screening Method Found To Detect Testicular Cancer In Its Initial Stages
9. A Novel Method For Measuring Interstitial Fluid Pressure In Cancer Tissues
10. A Novel Method Of Detection Of High Nuclear Grade Localized Renal Cell Carcinoma
11. New Method To Identify Protein Hot spots
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Method For Fighting Leukemia

(Date:7/21/2014)... Cannabis Now Magazine recently announced that ... summer. During these festivals, they will strengthen their relationship ... resources to attendees in an effort to continue their ... legitimate and beneficial side of cannabis. , The publication ... the Kush Expo in Anaheim, the Champs Trade Show ...
(Date:7/21/2014)... NY (PRWEB) July 21, 2014 The ... (“League”) and 1199SEIU United Healthcare Workers East (“1199SEIU”) today ... addresses critical issues facing healthcare providers and their employees. ... which will require ratification by League and 1199SEIU members, ... years. In addition, all existing worker benefits, including healthcare ...
(Date:7/21/2014)... human nature to hate losing. , Unfortunately, it,s ... abandoning a solid strategy and thus increasing your chances ... conclusion of a Brigham Young University study published this ... finding is based on an analysis of two decades ... focused on whether coaches adjusted their personnel following games ...
(Date:7/21/2014)... 21, 2014 Ticket Down is ... at the Sun Life Stadium in Miami Gardens, Florida ... between Brazil and Argentina is one that has been going ... rivalries are forming with each passing day. One rivalry that ... Brazil and another South American nation, Colombia. The two teams ...
(Date:7/21/2014)... that HIV and its monkey equivalent, SIV, gain a ... making it difficult to completely eliminate the virus even ... report that SIV can become entrenched in tissues fewer ... detectable in blood plasma (the liquid part) or blood ... Ph.D., of Beth Israel Deaconess Medical Center and the ...
Breaking Medicine News(10 mins):Health News:Cannabis Now Magazine Hits the Marijuana Festival Circuit and Sponsors Two Major Events 2Health News:League of Voluntary Hospitals and Homes and 1199SEIU Reach New Four-Year Collective Bargaining Agreement 2Health News:League of Voluntary Hospitals and Homes and 1199SEIU Reach New Four-Year Collective Bargaining Agreement 3Health News:'Moral victories' might spare you from losing again 2Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Reports Huge Demand for Colombia vs. Brazil Tickets at Sun Life Stadium in Miami in Early September 2Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Reports Huge Demand for Colombia vs. Brazil Tickets at Sun Life Stadium in Miami in Early September 3Health News:NIH-supported scientists demonstrate very early formation of SIV reservoir 2
... propose alternative that won,t burden patients, workers, ... Inc., which filed for bankruptcy protection in December, ... workers to ease its continued,financial troubles. However, caregivers ... care. At a rally, workers will unveil their ...
... Healthation CEO Scott Kornhauser,announced the appointment of ... today. Mr. Hebert was a former consulting partner ... complex solutions in the healthcare,industry., Mr. Hebert,s ... and growing market share for Healthation. Prior to,joining ...
... price to the regional, state, or ... nationwide averages, ... on their website, http://www.alijor.com . Users can now view,price summaries ... Provider" feature, patients can compare prices for,consultations, appointments, and follow up ...
... A compound found in grape seed extract reduces plaque ... of Alzheimer,s disease, new research shows. The study appears ... of Neuroscience . , Lead study author Giulio ... and colleagues found that the grape seed extract prevents ...
... cut body fat for those at risk of insulin resistance ... metformin slows the onset of early puberty and reduces the ... conditions, a Spanish study concludes. , "The findings indicate ... when puberty is faster in girls, the appearance of menses ...
... ROCHESTER, Minn., June 17 Researchers have,long suspected ... might affect survival rates following heart attack. In ... researchers present new data,suggesting that people with lower ... after heart attack than more affluent, educated people. ...
Cached Medicine News:Health News:Hospital Workers Say Concessions Will Diminish Patient Care 2Health News:Study indicates grape seed extract may reduce cognitive decline associated with Alzheimer's disease 2Health News:Study indicates grape seed extract may reduce cognitive decline associated with Alzheimer's disease 3Health News:Diabetes Drug May Prevent Early Puberty in Young Girls 2Health News:People With Lower Incomes, Lower Education Levels Have Higher Death Rates After Experiencing Heart Attack 2Health News:People With Lower Incomes, Lower Education Levels Have Higher Death Rates After Experiencing Heart Attack 3
(Date:7/21/2014)... , July 21, 2014 Thoratec Corporation ... device-based mechanical circulatory support therapies to save, support and ... its operating results for the second quarter of fiscal ... company will hold a conference call to discuss its ... parties, at 1:30 p.m., Pacific Daylight Time (4:30 p.m., ...
(Date:7/21/2014)... 2014  EHE International, the recognized leader in preventive ... network, today announced that Dignity Health Medical Group Nevada, ... has been named an EHE-certified preventive care center. Through ... region now have greater access to EHE,s ... "EHE is proud to add Dignity ...
(Date:7/21/2014)... , July 21, 2014 /PRNewswire-iReach/ -- Top ... GPM Pediatrics responds to an article, which suggests that ... Logo - http://photos.prnewswire.com/prnh/20140718/128611 ... about giving coffee to children, but now it happens ... . A new study, published in the journal Pediatrics, ...
Breaking Medicine Technology:Thoratec Schedules Second Quarter Conference Call, Webcast 2EHE International Certifies Dignity Health Medical Group Nevada, LLC as Its Newest Partner 2Dr. Michael Gabriel a Brooklyn Pediatrician Comments on an Article, Which Suggests Caffeine May Be Dangerous for Children 2
... Leading orthopaedic surgeon Simon Moyes has launched a ... from the surgeon,s viewpoint and from inside the joint. ... kind, has been developed by Simon Moyes along ... devices, and is aimed at students, junior surgeons and patients ...
... Jan. 11, 2012  SuccessEHS announces that its newest release ... times when compared to previous releases.  The company has ... Record (EHR) and Practice Management software solution ... The upcoming release will focus on user efficiency and ...
Cached Medicine Technology:Simon Moyes Pioneers New Keyhole Surgery Website 2Newest SuccessEHS Release to Increase Physician Software Usability 2Newest SuccessEHS Release to Increase Physician Software Usability 3
Wet-Field Hemostatic Eraser bipolar tip, packsize is 10/box....
... of foldable intraocular lenses. The instrument consists ... under the implant and divides the implant ... support both halves of the lens so ... the anterior chamber is avoided. The instrument ...
Shafts angled 8 mm from tip to bend with smooth jaws. Flat, cross action handle with holes and dull finish....
Bi-angled insertion jaws designed to enhance surgeon comfort and efficiency. Reverse action releases lens when handle is compressed. Made in titanium....
Medicine Products: