Navigation Links
New Mechanism Identified for Resistance to Targeted Lung Cancer Drugs

An international research team, led by investigators from the Massachusetts General Hospital (MGH) Cancer Center and Dana-Farber Cancer Institute (DFCI), has found// a new way that some lung tumors become resistant to treatment with targeted therapy drugs like Iressa and Tarceva. Their report, which will appear in the journal Science and is receiving early online release, describes a totally new resistance mechanism that may apply to many types of cancer. It also suggests a treatment strategy for patients with these resistant tumors.

"We found that, for about 20 percent of patients with tumors that become resistant to Tarceva or Iressa, resistance is caused by the genetic activation of an oncogene that is not the normal target of the drug, which is something that has never been seen before," says Jeffrey Engelman, MD, PhD, scientific director of the MGH Center for Thoracic Cancers, the paper's lead author.

"Importantly, we also identified a potential new way to treat these resistant tumors with combination therapy directed against both protein targets," adds Pasi A. J?nne, MD, PhD, of the Lowe Center for Thoracic Oncology at DFCI, the study's senior author.

Drugs like Iressa (gefitinib) and Tarceva (erlotinib) are used to treat advanced non-small-cell lung cancer (NSCLC), the leading cause of cancer deaths in the U.S. They act by blocking the epidermal growth factor receptor (EGFR), a molecule on the surface of cancer cells. In 2004 research teams from MGH and DFCI found that only tumors in which the EGFR gene has been mutated in a way that magnifies the cells' response to the growth factor, a process that fuels tumor growth, were sensitive to treatment with these drugs.

Although tumors that respond to EGFR inhibitors do so rapidly and dramatically, eventually the tumors become resistant and resume growing. About half the time, a secondary mutation that interferes with the drugs' binding to the receptor develops within
'"/>




Page: 1 2 3

Related medicine news :

1. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
2. New Gene Silencing Mechanism To Prevent Cancer
3. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
4. Self-defense Mechanism of food borne bugs found
5. Specific Immune Mechanism against DNA viruses
6. A New Focus For The Mechanism Of Nerve Growth
7. Mechanism of Stem Cell Regulation Identified
8. Cancer-Killing Viruses Employ Multiple Mechanisms
9. Regulatory Mechanism for Tumor Suppressor Protein Identified
10. Study Identifies Mechanism Which May Help Tamoxifen Work Better
11. Genetic Mechanism Helps Explain Chronic Pain Disorders
Post Your Comments:
(Date:7/1/2015)... ... July 01, 2015 , ... The 28th annual Charity Horse Show hosted by ... 2015, at 6 p.m. in Pugh Bourne Park, 343 Oakfield Road. The event will ... zoo, an Elvis impersonator, a silent auction and concessions. , Horses and riders from ...
(Date:7/1/2015)... ... July 01, 2015 , ... Convoy of Hope will partner ... Twin Cities on Saturday, August 1, at Spring Lake Park High School. , During ... than $1 million worth of goods and services including free food, health services, family ...
(Date:7/1/2015)... ... July 01, 2015 , ... RowdMap ... to newly released white paper: “Pro-actively Identifying the High-Cost Patient Population: Insights from ... and is available at: http://www.hcttf.org/resouces-tools . , The Healthcare Transformation Task Force ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... Franklin University, ... announce Dr. Leslie King has been named Dean of the College ... Dean, Dr. King will promote and support the vision and mission of Franklin University ...
(Date:7/1/2015)... Luis Obispo, CA (PRWEB) , ... July 01, ... ... non-surgical bunion treatment, announces their big summer sale. Customers purchasing two or ... with promo code "Summer15". , Bunion Bootie temporarily corrects misaligned toes ...
Breaking Medicine News(10 mins):Health News:Convoy of Hope Hosts Community Event in the Twin Cities 2Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 2Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 3Health News:Franklin University Appoints Dean of College of Health & Public Administration 2Health News:Bunion Bootie, the #1 Non-Surgical Treatment for Bunion Pain, Announces Their Big Summer Sale 2
... soon be roaming our pastures, reports Cath ODriscoll in Chemistry ... New Zealand have discovered that some cows have genes that ... plan to use this information to breed herds of milkers ... to breed commercial herds producing milk with the unique characteristics ...
... - including India's - met European Union members in the ... ,The two-day Asia-Europe Meeting (ASEM) of 43 nations ... deep cuts in world carbon-dioxide emissions and Asian governments countering ... every two years. India, Pakistan and Mongolia are attending for ...
... of Northwestern University, is a super sleuth of potentially ... team of doctors called RADAR (Research on Adverse ... School of Medicine. They swoop in to investigate early ... Administration (FDA) takes notice. ,A new study ...
... Court on Friday announced that it has accepted a ... to review the constitutionality of a Mexico City law ... the first three months' gestation, the Los Angeles Times ... Democratic Revolution in March in the Mexico City Legislature ...
... Girl bands such as Girls Aloud, Pussycat Dolls and the ... that by promoting an ideal for what a womans figure ... teenage girls. ,Researchers from the universities of Leeds ... such groups where all the band-members are skinny, found that ...
... and Biochemical Zoology, a fascinating new selection of ... artificial selection, providing insight into how organisms ... ,Dr. James Hicks, Editor in Chief of ... papers: "This exciting approach experimental evolution ...
Cached Medicine News:Health News:Genes That Produce 'skimmed Milk' in Cows Identified 2Health News:EU Pushes Asian Nations on Climate Change Goals 2Health News:Researchers Found Drug Effects of Deadly Prescription Well Before FDA 2Health News:Researchers Found Drug Effects of Deadly Prescription Well Before FDA 3Health News:Mexico Supreme Court Accepts Petition To Review Mexico City Law Legalizing Abortion During First Three Months' Gestation 2Health News:Research Throws Light on Adaptation of E.coli to Changing Conditions 2
(Date:6/30/2015)... 1, 2015 Inventor of ... ana team   NuCana, a clinical ... and commercialise a portfolio of novel anti-cancer medicines, today ... as Chief Scientific Officer. Professor McGuigan was ... currently Professor of Medicinal Chemistry at the Cardiff School ...
(Date:6/30/2015)... June 30, 2015 Nortek Security & ... NTK ) and a leader in the residential ... announced it acquired mobile personal emergency response system ... Numera, Inc. Headquartered in ... implemented, mobile PERS products and cloud-based software platforms ...
(Date:6/30/2015)... 2015   Millar, Inc. , a leader in ... 2016 retirement of Craig Thummel , President/CEO and ... of service to the Company. The Company also announced ... of the Executive Management team as his successors. The ... currently Director of Sales and Marketing, as President, and ...
Breaking Medicine Technology:Internationally Renowned Medicinal Chemist Professor Chris McGuigan Appointed as NuCana's Chief Scientific Officer 2Internationally Renowned Medicinal Chemist Professor Chris McGuigan Appointed as NuCana's Chief Scientific Officer 3Nortek Security & Control Acquires Health and Wellness Technology Business from Numera 2Nortek Security & Control Acquires Health and Wellness Technology Business from Numera 3Nortek Security & Control Acquires Health and Wellness Technology Business from Numera 4Millar, Inc. Announces Leadership Changes 2Millar, Inc. Announces Leadership Changes 3
This camouflaging lens features the solid black stripes of the lightning fast African zebra, on a white iris background....
Sphere Introducer...
Reusable cannula with .90 mm (20 g) shaft, tapering to .30 mm (30 g). Angled 125 3 mm from tip and flattened for easy insertion into the subretinal space....
... tip cannula allows atraumatic access ... for aspiration of subretinal fluids. ... beyond end of cannula. ... secure connection to a backflush ...
Medicine Products: