Navigation Links
New Light on Working of Brain Networks

“Guanfacine can strengthen the connectivity of these networks by keeping these channels closed, thus improving working memory and reducing distractibility,” she said. “This is the first time we have observed the mechanism of action of a psychotropic medication in such depth, at the level of ion channels.”

Arnsten said the excessive opening of HCN channels might underlie many lapses in higher cognitive function. Stress, for example, appears to flood PFC neurons with cAMP, which opens HCN channels, temporarily disconnects networks, and impairs higher cognitive abilities.

There is also evidence that this pathway may not be properly regulated with advancing age, resulting in destruction of cAMP. The dysregulation of the pathway may contribute to increased forgetfulness and susceptibility to distraction as we grow older.

The research is also relevant to common disorders such as ADHD, which is associated with weaker regulation of attention and behavior. ADHD is highly heritable, and some patients with ADHD may have genetic changes in molecules that weaken the production of norepinephrine. Treatments for ADHD all enhance stimulation of the norepinephrine receptors.

These new data also have important implications for the researchers’ studies of more severe mental illnesses like schizophrenia and bipolar disorder, which can involve mutations of a molecule called DISC1 (Disrupted in Schizophrenia) that normally regulates cAMP. Loss of function of DISC1 in patients with schizophrenia or bipolar disorder would increase vulnerability to cortical network disconnection and profound PFC deficits. This may be especially problematic during exposure to even mild stress, which may explain the frequent worsening of symptoms following exposure to stress. “We find it remarkable to relate a genetic mutation in patients to the regulation by an ion channel of PFC neuronal networks,” said Arnsten.

Co-authors include Min Wang, Br
'"/>




Page: 1 2 3

Related medicine news :

1. Light therapy decreases depression during pregnancy
2. Light therapy devotes new hope in advanced lung cancer
3. Reducing TB With Ultraviolet Light
4. Exposure To Night Light may Increase The Risk Of Leukemia
5. Improving Lighting Could Bring About A Change In Alzheimers Patients
6. Light Cigarettes - Not So Light?
7. Fungal Infections Effectively Controlled By Light Therapy
8. Light can help fight gum bacteria
9. Lights can lighten your moods
10. Night Light Found To Increase The Risk Of Leukemia
11. UV- Light Tanning As A Type Of Substance-Related Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Light Working Brain Networks

(Date:12/15/2014)... OutMarket , a provider of marketing automation ... Sheets ,” a guide that exposes the insider secrets ... top ten social media networks. , Social media ... and customer service. It can also increase new leads ... new networks and weather constantly changing algorithms, they need ...
(Date:12/15/2014)... Steven Reinberg HealthDay Reporter ... large, new study should reassure the millions of American women ... for breast cancer. "There is no association between migraine ... associate professor of medicine at Harvard Medical School. "There is ... and there is no protective effect either." About 18 ...
(Date:12/15/2014)... The increase in prevalence of disabling hearing loss in the ... contributing to the growth in the global audiological market. Devices ... loss and balance disorders are known as audiological devices. An ... amplifier. The global market is expected to grow at a ... 2014 to 2019. Some of the factors which are driving ...
(Date:12/15/2014)... Emergo Group, Inc., a medical device ... North and South America, Europe, the Middle East, Asia ... for its 2015 Medical Device Industry Survey. Each year, ... business and market trends as well as regulatory and ... areas including:, , Overall prospects for ...
(Date:12/15/2014)... CA (PRWEB) December 15, 2014 At ... the organizations AutismOne and Focus Autism ... enlighten attendees with research on the effects of toxins ... testing and intervention information. , Luminaries such as ... researchers from abroad with esteemed, credentialed colleagues of the ...
Breaking Medicine News(10 mins):Health News:OutMarket Releases Cheat Sheets for Social Media Marketing 2Health News:OutMarket Releases Cheat Sheets for Social Media Marketing 3Health News: No Link Between Migraine, Breast Cancer Risk, Study Says 2Health News:Audiological Devices Market 2019 Demand for Esthetic Hearing Aids Drives the Growth, Says a Report at ReportsnReports.com 2Health News:Audiological Devices Market 2019 Demand for Esthetic Hearing Aids Drives the Growth, Says a Report at ReportsnReports.com 3Health News:Audiological Devices Market 2019 Demand for Esthetic Hearing Aids Drives the Growth, Says a Report at ReportsnReports.com 4Health News:Emergo’s Annual Survey Assessing the State of the Medical Device Industry Now Open 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... Holdings, Inc.,(NYSE: ZMH ; SWX: ZMH) today announced ... Board and a member of the Board of Directors ... the Company. John L.,McGoldrick, a current Board member, will ... Chairman, President and Chief Executive Officer,of the Company from ...
... Gen-Probe Incorporated,(Nasdaq: GPRO ) announced today that ... in London on Thursday, December 6, 2007 at,approximately 10:45 ... is scheduled to be webcast live and may be ... Gen-Probe,s website at, http://www.gen-probe.com . The webcast will be ...
... J. Robert Scott, a leading,retainer-based executive search ... in,professional services; and the internationally recognized law ... Harvard Business School,have released data for their ... available at http://www.compstudy.com . This study ...
... Covance Sells Centralized ECG Business; Enters Exclusive Ten Year ... Marketing Agreement with eRT ... today that it has agreed to sell its centralized ECG,business to ... its clients cardiac safety services through eRT,s robust,centralized ECG platform. The ...
... N-Myc gene lives a double life, triggering cancer when ... suicide in the absence,of IL-3, MEMPHIS, Tenn., Nov. ... in certain white blood cells when it is overexpressed,helping ... while,triggering apoptosis, or cell suicide, under other conditions, according ...
... U.S. Career Institute, a,nationally accredited distance learning school, ... Assistant career training course.,The Medical Assistant course is their ... "The Medical Assistant course is a big step for ... school," said Ann Rohr,president of U.S. Career Institute. "Our ...
Cached Medicine News:Health News:Ray Elliott to Retire as Chairman of Zimmer Holdings; John McGoldrick to Serve as Non-Executive Chairman 2Health News:Ray Elliott to Retire as Chairman of Zimmer Holdings; John McGoldrick to Serve as Non-Executive Chairman 3Health News:Gen-Probe to Webcast Presentation at NASDAQ 20th Investor Program 2Health News:2007 Life Sciences Compensation Findings Disclosed www.compstudy.com 2Health News:2007 Life Sciences Compensation Findings Disclosed www.compstudy.com 3Health News:2007 Life Sciences Compensation Findings Disclosed www.compstudy.com 4Health News:Covance Agrees to Enter Strategic Relationship with eResearchTechnology to Offer its Clients eRT's Centralized Cardiac Safety Services 2Health News:Covance Agrees to Enter Strategic Relationship with eResearchTechnology to Offer its Clients eRT's Centralized Cardiac Safety Services 3Health News:St. Jude Researchers Identify Key Genetic Trigger of Acute Myeloid Leukemia 2Health News:U.S. Career Institute Launches 1st Ever DETC Accredited Medical Assistant Course 2
(Date:12/15/2014)... BOSTON , December 15, 2014 /PRNewswire/ ... drug discovery and development company, is pleased to announce ... the United States relating to its GPCR-focused ... the US significantly strengthens the global patent estate covering ... The suite of patents recently granted by ...
(Date:12/13/2014)...  Radiologists can transmit their reports, which can ... physicians, electronic health records (EHR) systems securely, efficiently, ... That was the message behind a ... the recent Radiology Society of North America Meeting ... in this manner also helps referring physicians satisfy ...
(Date:12/13/2014)... , Dec. 12, 2014  Novo Nordisk, a world ... today announced a multi-year extension of their partnership, that will ... 83 Novo Nordisk Chip Ganassi Racing entry, driven by ... Kimball, 29, from Camarillo, California , ... the history of INDYCAR to win a race at the ...
Breaking Medicine Technology:Heptares Extends Global Patent Protection for GPCR-Focused Drug Discovery Platform With Grant of Core Patents in the United States 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 2Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 4Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 5Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 6Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 7
... 31, 2011 Thoratec Corporation (Nasdaq: THOR ), ... save, support and restore failing hearts, announced today that it ... the outstanding Senior Subordinated Convertible Notes due 2034 (CUSIP No. ... 30, 2011 there were 243,382 notes outstanding, which can be ...
... 31, 2011 Conatus Pharmaceuticals Inc. announced today ... CTS-1027 in combination with Peginterferon Alpha-2a (Pegasys®) and ... virus (HCV) null-responder patient population.  Null-responder patients are ... are clinically defined as those patients failing to ...
Cached Medicine Technology:Thoratec Corporation Announces Redemption of Senior Subordinated Convertible Notes Due 2034 2Thoratec Corporation Announces Redemption of Senior Subordinated Convertible Notes Due 2034 3Conatus Pharmaceuticals Presents Results From a Phase 2 Clinical Trial of CTS-1027 in HCV Genotype 1 Null-Responders 2
... Packed conveniently in plastic-wrapped racks of 96 ... useno need to autoclave. Sterilized Diamond Tips ... sterilization and are delivered with a certificate ... Sterilized Diamond Tips are certified free of ...
... Finntips have been designed to optimize the ... of our tip products is widely recognized ... range has been extended over the years ... standard and special tips including filter tips, ...
This large orifice 1000 ul tips is the large volume alternative to MBP's 200G tip. Pipet fragile cells, viscous samples and genomic DNA with ease....
... to optimize the accuracy and precision of ... is widely recognized by customers throughout the ... over the years and now covers a ... including filter tips, certified pure tips, stepper ...
Medicine Products: