Navigation Links
New Iron Regulation Discovery by Children's Hospital

A new study co-authored by Children's Hospital Oakland Research Institute (CHORI) senior scientist, Elizabeth Theil, Ph.D., is the first to show that partial copies// of DNA called mRNA (or messenger RNA) morph into specific three dimensional shapes when it combines with a protein regulator called IRP1. This discovery is incredibly important to researchers who design medications based on the specific characteristics of a disease.

The study, featured in the December issue of Science, contains some significant surprises about the structure and protein plasticity of IRP1 and the mRNA. Dr. Theil chairs the Council on BioIron at CHORI and is a professor at the University of California, Berkeley. She co-authored the study with William Walden, Ph.D. a professor of microbiology and immunology and his colleague, Karl Voltz, Ph.D., an associate professor at the University of Illinois at Chicago.

The researchers found that when mRNA and IRP1 join they change shapes to fit each other. In addition, the IRP1 changes its role from being an enzyme to an iron regulator. Each mRNA codes one or two proteins in the body. In this case the coded protein was Ferritin, which is essential for managing iron in the body. This discovery could help researchers design medications for patients with iron overload that occurs in hemochromotosis, Sickle Cell Disease and Thalassemia.

"Currently, there are medications available that are based on DNA structures such as anti-cancer drugs. Unfortunately, the problem with targeting DNA is that both healthy and cancerous cells have the same DNA, but they also have different mRNAs. Consequently, our research findings could help scientists design medications that target mRNAs," said Dr. Theil.


Page: 1

Related medicine news :

1. Platelets May Be The Source Of Gene Regulations
2. Novel Rules And Regulations For Cardiovascular Catheterization Labs.
3. microRNA And Its Role In Synaptic Regulation
4. Nervous System Plays Role In Stem Cell Regulation
5. Bill for Formal Regulation of Tanning Salons
6. Study Highlights Appetite Regulation Pathway, New Hope for Weight Loss
7. WHO Calls For More Regulation On Tobacco Products
8. Site of Sleep Regulation Identified in Fruit Flies
9. Mechanism of Stem Cell Regulation Identified
10. Natural Approach to Immune Regulation May Help Transplant Patients
11. Regulation of Infertility Clinics Needed
Post Your Comments:

(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a missionary ... Journey: From the Mountains to the Mission Field” is the creation of published author, ... ages and currently teaches a class of ladies at her church, which she has ...
(Date:10/12/2017)... ... ... Planet Fitness, one of the largest and fastest growing franchisors and operators ... location in Covington, LA at 401 N. U.S. Highway 190, in January of 2018. ... in the Holiday Square shopping center. Its location allows it to serve both Covington ...
(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
(Date:10/12/2017)... D.C. (PRWEB) , ... October 12, 2017 , ... Leading ... their peers in Washington, D.C., for the 49th Congress of the International Society ... ., Vice President of the Center for Cancer and Blood Disorders at ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the United States, single-family ... some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average ... extremely low property-tax rates, which contributes to the relatively lower cost of living ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
(Date:10/2/2017)... The Rebound mobile app is poised to become ... tide of prescription drug addiction. The app empowers users to ... stepping down their dosage in a safe, controlled manner while ... the first 100,000 people to sign up will enjoy 3 ... ...
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), ... solutions, today announced that its MyDario product is expected to appear on ... for when The Dr. Oz Show airs in your area: ... The nine-time Emmy award-winning, The Dr. ... ...
Breaking Medicine Technology: