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New International Study to Test Exercise in Heart Failure Patients

grams would qualify for Medicare if the study is positive.

There are 84 clinical study sites in the trial across North America and Europe. At the Wake Forest Baptist site, 120 participants have been enrolled so far, the second-highest number across all sites.

The patients in the study will receive either exercise training or “usual care.” Those in the exercise arm will receive 36 supervised exercise training sessions at a facility, using either bikes or walking. After the first 18 sessions, the patients will start home-based exercise, and will exercise exclusively at home after the second 18 sessions. They’ll come back for facility-based training every three months.

The supervised training protocol is based on the traditional cardiac rehabilitation program of 36 sessions currently covered by insurers for patients after heart bypass surgery.

All patients in HF-ACTION will receive a self-management education program on topics such as medicines and their side effects, managing fluids, the importance of adhering to a low sodium diet.

The patients will be followed for up to four years through clinic visits, specialized tests, and telephone calls. In their comparison of the two groups, the investigators will record deaths and hospitalizations for all causes. They’ll also measure changes in the maximum exercise time and quality of life.

Vinay Thohan, M.D., director of the heart failure service at Wake Forest Baptist, said “Five million Americans have heart failure with 550,000 new cases diagnosed each year. Despite optimal drug treatment, many heart failure patients die and others are faced with repeated hospitalizations, and have difficulty getting around, even for a few steps.

“Exercise training represents an intervention that if proven beneficial should be accessible to most heart failure patients due to its relatively low cost, high availability and ease of use,” Thohan said.
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