Navigation Links
New International Study to Test Exercise in Heart Failure Patients

Cardiologists at Wake Forest University Baptist Medical Center are helping to lead a large international study // involving 83 other sites that will test 3,000 patients in an effort to determine whether exercise really is good for heart failure patients.

Though doctors have promoted the value of exercise for a variety of disorders for years, “exercise training has not been definitively established as safe in the group of patients who primarily have heart failure,” said Dalane W. Kitzman M.D., a cardiologist who is principal investigator at Wake Forest Baptist, and colleagues, writing in the American Heart Journal.

“Controlled clinical trials have shown that exercise training improves physiological measurements” such as the distance that patients can walk in six minutes, they said after analyzing 14 trials. “None of these trials enrolled a sufficient number of patients to properly evaluate the impact of exercise training on death and hospitalization.”

The new trial, called Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) “is the largest randomized clinical trial of exercise training ever performed,” Kitzman said. “The trial represents a critical step in establishing exercise as a therapy for patients with left ventricular dysfunction” (reduced heart contractions).

He added, “The patient population enrolled in this trial will be a broad representation of heart failure patients, including large numbers of women, minorities and people from low socio-economic status.”

“The HF-ACTION trial has been designed so that if the intervention is beneficial, the treatment can be translated rapidly into general practice,” Kitzman said. In fact, the study leaders have met with Centers for Medicare & Medicaid Services, the office that assesses whether there is enough proof that a treatment is effective and safe in order to be paid for by Medicare, to help ensure that exercise pro grams would qualify for Medicare if the study is positive.

There are 84 clinical study sites in the trial across North America and Europe. At the Wake Forest Baptist site, 120 participants have been enrolled so far, the second-highest number across all sites.

The patients in the study will receive either exercise training or “usual care.” Those in the exercise arm will receive 36 supervised exercise training sessions at a facility, using either bikes or walking. After the first 18 sessions, the patients will start home-based exercise, and will exercise exclusively at home after the second 18 sessions. They’ll come back for facility-based training every three months.

The supervised training protocol is based on the traditional cardiac rehabilitation program of 36 sessions currently covered by insurers for patients after heart bypass surgery.

All patients in HF-ACTION will receive a self-management education program on topics such as medicines and their side effects, managing fluids, the importance of adhering to a low sodium diet.

The patients will be followed for up to four years through clinic visits, specialized tests, and telephone calls. In their comparison of the two groups, the investigators will record deaths and hospitalizations for all causes. They’ll also measure changes in the maximum exercise time and quality of life.

Vinay Thohan, M.D., director of the heart failure service at Wake Forest Baptist, said “Five million Americans have heart failure with 550,000 new cases diagnosed each year. Despite optimal drug treatment, many heart failure patients die and others are faced with repeated hospitalizations, and have difficulty getting around, even for a few steps.

“Exercise training represents an intervention that if proven beneficial should be accessible to most heart failure patients due to its relatively low cost, high availability and ease of use,” Thohan said.


Related medicine news :

1. International community warns India on HIV situation
2. Key step forward on International Health Rules
3. ICMR along with other International Research organisation with drug development for Neglected Diseases
4. International Osteoporosis Research Centre To Be Started In India.
5. Indian hospitals require International Accreditation
6. International Conference On Malaria - Laveran To Genomics
7. Delhi To Host International Women’s Congress From Nov 2
8. International conference on Ayurveda to be held on Kerala
9. International Teleradiology: The Future Of Radiologic Diagnosis
10. John Mendelsohn M.D, chosen for an International Award
11. Thailand To Procure Botulism Antitoxin Internationally
Post Your Comments:

(Date:11/27/2015)... (PRWEB) , ... November 28, 2015 , ... There is ... we outperform our billings from last year? , This question has not been an ... are coming to the retirement age and the younger workforce don’t share the same ...
(Date:11/27/2015)... ... , ... According to an article published November 6th by The ... of British Columbia suggested that laws requiring bicyclists to wear helmets may not actually ... the reason for the controversial conclusion is that, while helmets have certainly prevented a ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... affecting the health care in America. As people age, more care is needed, ... costs are rising, and medical professionals are being overworked. The forgotten part of ...
(Date:11/27/2015)... ... November 27, 2015 , ... An ... way to dispense prescription medications at home, so he invented the patent-pending ELECTRONIC ... and dispense prescription medications. In doing so, it could help to prevent potential ...
(Date:11/27/2015)... ... 27, 2015 , ... Lizzie’s Lice Pickers just announced a special promotion that ... of their purchase of lice treatment product. In addition, customers will receive a complimentary ... spokesperson. “Finding lice is a sure way to ruin the holidays, so we encourage ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , 26 november 2015 AAIPharma ... de geplande investering aan van ten minste ... laboratoria en het mondiale hoofdkantoor in ... zal resulteren in extra kantoorruimte en extra ... de groeiende behoeften van de farmaceutische en ...
(Date:11/26/2015)... 2015 Research and Markets ( ) has ... Market Outlook to 2019 - Rise in Cardiac Disorders and ... report to their offering. Boston ... scientific and others. --> The ... Boston scientific and others. ...
(Date:11/26/2015)... , November 26, 2015 ... the addition of the  "2016 Future ... Global Cell Surface Testing Market: Supplier ... to their offering.  --> ... of the  "2016 Future Horizons and ...
Breaking Medicine Technology: