Navigation Links
New Insights into Prion Propogation

Prions -- infectious, oddly-folded proteins that are the main suspects in fatal neurodegenerative diseases such as Cruetzfeldt-Jakob and bovine spongiform encephalopathy , or "mad cow" -- remain mostly a mystery to scientists. Very few prions have been fully described. How they infect and propagate is not fully understood.

New insights into prion propagation reported in the Molecular Cell by Susan Liebman, distinguished university professor of biological sciences at the University of Illinois at Chicago, may help tug back the veil on the behavior and variety of these potentially lethal molecules.

The work was done with former UIC post-doctoral fellow Vibha Taneja and University of Bordeaux researchers Sven Saupe, Marie-Lise Maddelein and Nicholas Talarek.

Previously, Liebman focused her studies on prion-forming proteins found in baker's yeast, while Saupe's research looked at prion protein in another fungus.

A key difference between the two is that the yeast prion proteins are rich in the amino acids glutamine and asparagine in the regions of the protein used to transform them into a prion. In contrast, the fungal prion lacks a rich supply of these amino acids -- a characteristic it shares with the prion-forming protein in mammals, which is otherwise dissimilar.

The researchers showed, by fusing the prion-forming domain of the fungal protein to a reporter protein, that the fungal prion could propagate in yeast.

"We showed that the fusion formed a prion in yeast and it was infectious," Liebman said. "It's the first time a prion from one organism has been propagated in another organism that normally lacks that prion. It demonstrates that totally heterologous prion propagation is possible.

"Surprisingly, the presence of a glutamine and asparagine-rich yeast prion that helps other yeast prions to form also helped this one to form," Liebman said, showing that prions of one type can interact with a dissimilar type.

Liebman said the finding suggests the possibility that yeast itself may contain non-glutamine and asparagine-rich prions. "We just haven't looked for them," she said.

The finding also underscores the value of the yeast model for studying factors necessary to propagate prions, now that it's been shown that propagation is not necessarily host-specific.

Liebman said the research emphasizes the need to look for new prions."How many more are there" Are there lots that we haven't looked at" How do we look for them" These are open questions."


'"/>




Related medicine news :

1. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
2. Reindeer Provide Valuable Insights Into Sleep Disorders
3. Insights Into Lead Pollution
4. Insights into Osteosarcoma in Cats and Dogs may Improve Palliative Care
5. New Insights into Antimalarial Drug Resistance
6. Neural Basis of Anxiety: Newer Insights
7. New Insights into Chronic Inflammation and Atherosclerosis
8. Rare Womens Lung Disease May Yield Insights Into Common Diseases
9. Insights into Acute Promyelocytic Leukemia
10. Neurotransmitter That can Yield New Insights in the Fight Against Diabetes Identified
11. Deep Insights into Type2 Diabetes by Wesley Researchers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... over $100,000 for its innovative EcoQube Frame vertical micro-veggies garden on Kickstarter ... demand for the product – with nearly 2,000 consumers (and counting) already backing ...
(Date:3/24/2017)... ... March 24, 2017 , ... On June ... ERISA Benefit Claims Litigation seminar in Chicago, Illinois. She will present on: ... of cases litigated under ERISA involve claims for long-term disability benefits. This ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... ) announced their partnership to prep patients for colonoscopy at the HyGIeaCare® Center ... in 87th Ave., Miami, FL. , The HyGIeaCare® Prep, cleared by ...
(Date:3/24/2017)... ... 24, 2017 , ... “Finding Christ Through Social Media: Year ... chronicling the writer’s path toward true communion with God. “Finding Christ Through Social ... the creation of published author Lea Michelle Johnson, a follower of Christ, wife ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The Communion of Saints: A ... God in congregations across the United States. “The Communion of Saints” is ... who has served congregations in seven states throughout his long career of devotion ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... HICKORY, N.C. , March 23, 2017  Transportation ... accolades as an end-to-end supply chain management firm with ... of Consumer Product Solutions Rick Zaffarano was ... Star of the Supply Chain by the only publication ... the global food supply chain. "Rick has ...
(Date:3/23/2017)... 2017 Summary ... pipeline guide Primary Hyperoxaluria - Pipeline Review, H1 ... (Genito Urinary System And Sex Hormones) pipeline landscape. ... by recurrent kidney and bladder stones. It results ... Symptoms include blood in the urine, pain when ...
(Date:3/23/2017)... 23, 2017 Research and Markets has announced ... report to their offering. ... The global oxygen therapy devices market to grow ... The report, Global Oxygen Therapy Devices Market 2017-2021, has been ... experts. The report covers the market landscape and its growth prospects ...
Breaking Medicine Technology: