Navigation Links
New Insights into Prion Propogation

Prions -- infectious, oddly-folded proteins that are the main suspects in fatal neurodegenerative diseases such as Cruetzfeldt-Jakob and bovine spongiform encephalopathy , or "mad cow" -- remain mostly a mystery to scientists. Very few prions have been fully described. How they infect and propagate is not fully understood.

New insights into prion propagation reported in the Molecular Cell by Susan Liebman, distinguished university professor of biological sciences at the University of Illinois at Chicago, may help tug back the veil on the behavior and variety of these potentially lethal molecules.

The work was done with former UIC post-doctoral fellow Vibha Taneja and University of Bordeaux researchers Sven Saupe, Marie-Lise Maddelein and Nicholas Talarek.

Previously, Liebman focused her studies on prion-forming proteins found in baker's yeast, while Saupe's research looked at prion protein in another fungus.

A key difference between the two is that the yeast prion proteins are rich in the amino acids glutamine and asparagine in the regions of the protein used to transform them into a prion. In contrast, the fungal prion lacks a rich supply of these amino acids -- a characteristic it shares with the prion-forming protein in mammals, which is otherwise dissimilar.

The researchers showed, by fusing the prion-forming domain of the fungal protein to a reporter protein, that the fungal prion could propagate in yeast.

"We showed that the fusion formed a prion in yeast and it was infectious," Liebman said. "It's the first time a prion from one organism has been propagated in another organism that normally lacks that prion. It demonstrates that totally heterologous prion propagation is possible.

"Surprisingly, the presence of a glutamine and asparagine-rich yeast prion that helps other yeast prions to form also helped this one to form," Liebman said, showing that prions of one type can interact with a dissimilar type.

Liebman said the finding suggests the possibility that yeast itself may contain non-glutamine and asparagine-rich prions. "We just haven't looked for them," she said.

The finding also underscores the value of the yeast model for studying factors necessary to propagate prions, now that it's been shown that propagation is not necessarily host-specific.

Liebman said the research emphasizes the need to look for new prions."How many more are there" Are there lots that we haven't looked at" How do we look for them" These are open questions."


'"/>




Related medicine news :

1. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
2. Reindeer Provide Valuable Insights Into Sleep Disorders
3. Insights Into Lead Pollution
4. Insights into Osteosarcoma in Cats and Dogs may Improve Palliative Care
5. New Insights into Antimalarial Drug Resistance
6. Neural Basis of Anxiety: Newer Insights
7. New Insights into Chronic Inflammation and Atherosclerosis
8. Rare Womens Lung Disease May Yield Insights Into Common Diseases
9. Insights into Acute Promyelocytic Leukemia
10. Neurotransmitter That can Yield New Insights in the Fight Against Diabetes Identified
11. Deep Insights into Type2 Diabetes by Wesley Researchers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... , ... June 27, 2016 ... ... the patient payment industry today announced its strategic partnership with Connance, a ... workflows. , The two companies’ proven, proprietary technology combine to provide health ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a ... can give their videos a whole new perspective by using the title layers ... Film Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can ... Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey ... cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: ... and sells medical devices and wearable sleep respiratory products ... cooperation agreement with Hongyuan Supply Chain Management Co., Ltd. ... 20, 2016, to develop Dehaier,s new Internet medical technology ... will leverage Hongyuan Supply Chain,s sales platform to reach ...
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Market - Forecast to 2022" report to their offering. ... method for the patients with kidney failure, it replaces the ... from the patient,s blood and thus the treatment helps to ... chloride in balance. Increasing number of ESRD ...
Breaking Medicine Technology: