Navigation Links
New Insights into Antimalarial Drug Resistance

to the liver within minutes, grows and divides there, and then ruptures liver cells, spewing many new parasites into the blood. A fever results from the infection, and this is followed by repeated cycles of mounting parasitic reproduction within red blood cells and accompanying fever.

During red blood cell infection, P. falciparum degrades the hemoglobin in the red cell, producing a toxic byproduct known as heme, which the parasite then crystallizes so that it wont be poisoned by it. Eventually, however, an infected person can die from cerebral hemorrhages or anemia that are consequences of red cell infection.

Natural products such as quinine, extracted from the cinchona tree, and leaves from the artemisinin shrub were the only options available to treat the infection until World War II, when both Germany and the United States started massive drug discovery programs based on the toll the parasite was having on soldiers -- more U.S. soldiers died from malaria in the Pacific than from all enemy fire, Roepe said.

The Germans first invented chloroquine (CQ), a synthetic version of quinine, which quickly became the treatment of choice because it was inexpensive and needs no refrigeration. The drug works by preventing heme crystallization, which destroys the parasite by building up toxic levels of non crystalline heme.

But because of the overuse of chloroquine, isolates of P. falciparum from around the globe have developed genetic mutations that make them resistant to that drug as well as other similar agents. Not all mutations found in all resistant isolates are the same, however. Parasites in different geographic regions have developed unique patterns of mutations in the three genes mentioned above.

Now, researchers can tell where a drug resistant parasite comes from depending on the varied mutations in the three different resistance genes, Roepe said. There are patterns of mutation
'"/>




Page: 1 2 3 4

Related medicine news :

1. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
2. Reindeer Provide Valuable Insights Into Sleep Disorders
3. Insights Into Lead Pollution
4. Insights into Osteosarcoma in Cats and Dogs may Improve Palliative Care
5. New Insights into Chronic Inflammation and Atherosclerosis
6. Neural Basis of Anxiety: Newer Insights
7. Antihistamine Could also be used as a Potential Antimalarial Drug
8. Link between birth weight and Insulin Resistance
9. Easier Methods Required to Screen Insulin Resistance
10. Easier Methods Required to Screen Insulin Resistance
11. Insulin Resistance Linked To Difference In Gender
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Insights into Antimalarial Drug Resistance

(Date:10/1/2014)... (PRWEB) October 01, 2014 Farmington ... including a redefined mission and visual identity helping ... of partnering with them to create greater benefit ... brand that focuses on empowering customers to better ... , The crown jewel of the rebrand is ...
(Date:10/1/2014)... Between 23 million and 50 million people suffer ... from the National Institutes of Health (NIH) and the ... them have something else in common: They have a ... Gluten Free Therapeutics, makers of CeliVites nutritional supplements, ... publishing a series of blog posts aimed at educating ...
(Date:10/1/2014)... Anti Aging Clinic (AntiAgingClinic.ca), the Greater Toronto ... choice, is announcing a discounted cost on Botox units, ... “We’re doing this because we want to give as ... clinic in Toronto,” says Dr. Brian Sieber, founder of ... Aging Clinic, including laser facials, genesis laser facials, ...
(Date:10/1/2014)... Watsonville, California (PRWEB) October 01, 2014 ... initiative to benefit a very special cause. The ... and support for Paws for Veterans, a nonprofit ... veterans, while also rescuing shelter dogs that would ... purchases of featured products will support monthly donations ...
(Date:10/1/2014)... OXNARD, CA (PRWEB) October 01, 2014 ... of the Anacapa Dental Art Institute in Oxnard and ... of Bangalore providing full mouth rehabilitation training. , “Speaking ... need of these transformative procedures to get the help ... mouth rehabilitation may involve repairing previous dental work, providing ...
Breaking Medicine News(10 mins):Health News:Farmington Company Launches Rebrand and New Positioning 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 3Health News:Anti Aging Clinic, the GTA’s Premier Provider of Anti Aging Treatments, Announces Deal on Units of Botox 2Health News:Nordic Naturals® Inspires Support for Paws for Veterans -- ‘Buy One Bottle. Help Two Heroes.’ Initiative Kicks Off October 1 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 3Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 4Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 5
... dengue virus Monday with 56 fresh cases being admitted to ... Delhi government called an// urgent meeting to review the situation. ... Institute of Medical Sciences (AIIMS) reported 41, taking the total ... 941 infected with the mosquito-borne virus, around 579 are residents ...
... Whenever one has to watch shaky images recorded by an ... ever consider how the brain //restores an almost continuous shaky ... back and forth taking also into consideration our bodies which ... ,Researchers at the Salk Institute for Biological Studies ...
... come up with novel methods to study 'better than nature' ... in maintaining a healthy cardiovascular system without the typical side ... presented at the Annual Meeting of the American College of ... high allicin garlic macerate can be delivered to the body ...
... extended to 2015. , The commission had been assigned the task ... needs of the mentally ill and was set to finish next ... response to the Mason Inquiry into Mental Health Services. They were ... has been trying to meet. , ,According to Health ...
... tide waits for no man and none other than ‘gen–present’ ... the ebb and flow of waters continue unabated, people are ... tomorrows. Living on the edge, seeking newer excitement propelled by ... obsession. Today, ‘failure’ is unacceptable - a mute ...
... of over 5,000 lbs. of ground beef as a precautionary ... that was processed and/or handled by the firm. ... that we have a negative test on the beef in ... proceed." ,It has been estimated that the 5,200 lbs. ...
Cached Medicine News:Health News:56 New Dengue Cases; Delhi Govt. to Review Situation 2Health News:Perception Stabilized – Thanks to Your Brains 2Health News:Perception Stabilized – Thanks to Your Brains 3Health News:New Garlic Product Mimics Garlic to Perfection 2Health News:Mental Health: Mind at Peace or in Pieces? 2Health News:Mental Health: Mind at Peace or in Pieces? 3Health News:Mental Health: Mind at Peace or in Pieces? 4Health News:Precautionary Recall of Beef over E.coli Contamination Concerns 2
(Date:9/30/2014)... LONDON , Sept. 30, 2014 ... conducting this study is to provide an overview ... global market for protein drugs/therapeutics. The key objective ... direction of protein drugs as an important tool ... report explores present and future strategies within the ...
(Date:9/30/2014)... 30, 2014  Decision Resources Group finds that the ... , China , India , ... strong rate through 2023. Dental implant procedure volumes will grow as ... rises. Other key findings from Decision Resources Group,s coverage ... , Dental implant penetration: Penetration of dental implants ...
(Date:9/30/2014)... 2014   Easy Breathe , the fastest growing ... that it now offers the revolutionary AirSense ... first sleep apnea therapy devices with internal cellular modems.  ... track and share real-time data on each user,s quality ... therapy.  In addition, the internal modem allows the CPAP ...
Breaking Medicine Technology:Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 2Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 3Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 4Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 2Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 3Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 2Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 3Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 4
The clarity and performance of glass with shatterproof safety of plastic....
Accurate and easy hematocrits in two minutes. Choose glass or easy to read SafeCrit plastic tubes, plain or heparinized. These tubes feature rapid capillary action and have a two-year shelf life. For...
... In the Innova™ 4100, the ... X-ray system for angiographic imaging, ... piece, non tiled Digital Detector ... reliably provide high resolution imaging ...
... is a bench-top fully automated random ... host of features usually only seen ... has the capacity to perform up ... ISEs, and offers primary tube sampling, ...
Medicine Products: