Navigation Links
New Insights into Antimalarial Drug Resistance

utes of Health, described in 2000 that the PfCRT gene is primarily responsible for the vast majority of drug resistance that leads to human death from malaria. Earlier this year, they also helped describe how the gene PfNHE likely contributes, and this turns out not to be as vital as PfCRT. Now, based in part on this study, they know that PfMDR1 is dependent on mutated PfCRT, and probably doesnt act independently.

The contribution of PfMDR1 to anti-malarial drug resistance is important, but much smaller than what many researchers thought it would be, said Roepe. Before the discovery of PfCRT, many thought PfMDR1 would be the primary culprit.

Roepe, and his two other co-authors, Georgetown researchers Linda Amoah, PhD, and Jacqueline Lekostaj, an MD/PhD student at Lombardi Comprehensive Cancer Center, employed an unusual method to construct the PfMDR1 gene.

They first obtained the PfMDR1 protein sequence from the NIH PubMed data base. They then back translated the protein sequence using a computer program to change the parasite gene sequence -- which combines nucleotide base pairs in a way that is found in no other life form -- into one that could be read by yeast. The yeast are then able to produce the PfMDR1 protein, in its proper sequence, from this synthetic gene.

They previously used this same technique to create and express a synthetic version of the much smaller PfCRT gene. PfMDR1 is made up of about 4,000 base pairs and its protein is particularly large, Roepe said, making the recent work much more challenging. Already, analysis of these three anti-malarial drug resistance genes is painting a picture of how the parasite escapes destruction by most of the agents now used against it, he said.

When a malaria parasite is transmitted through a mosquito bite, the mosquito injects the parasite into skin or blood, which then travels
'"/>




Page: 1 2 3 4

Related medicine news :

1. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
2. Reindeer Provide Valuable Insights Into Sleep Disorders
3. Insights Into Lead Pollution
4. Insights into Osteosarcoma in Cats and Dogs may Improve Palliative Care
5. New Insights into Chronic Inflammation and Atherosclerosis
6. Neural Basis of Anxiety: Newer Insights
7. Antihistamine Could also be used as a Potential Antimalarial Drug
8. Link between birth weight and Insulin Resistance
9. Easier Methods Required to Screen Insulin Resistance
10. Easier Methods Required to Screen Insulin Resistance
11. Insulin Resistance Linked To Difference In Gender
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Insights into Antimalarial Drug Resistance

(Date:2/28/2015)... Janesville, WI (PRWEB) February 28, 2015 ... The designation recognizes Mercy Harvard Hospital as stroke capable ... to be brought via ambulance to Mercy Harvard Hospital. ... the state to indicate their ability to treat stroke ... The designation allows ambulances transporting stroke patients to bypass ...
(Date:2/28/2015)... Memphis, TN: MedixSafe has retracted a ... new security reader named Guardian 2. The correct ... new biometric scanner that significantly increases the complexity ... new biometric scanner provides fast and easy access ... narcotics lockers with Vanguard technology tracks ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 1Heart ... and showcased emerging brand at Houston Texas Franchise ... Las Vegas sending its executive delegates headed by ... Business Development and Training Randolph Clarito. , Franchise ... was held last February 4-7 and featured Franchise ...
(Date:2/27/2015)... Santa Clara, CA (PRWEB) February 27, 2015 ... Integrated Passive Devices (IPD), has introduced miniature, wire bondable, ... Brightness and Power LED markets. The ESD88NP ... high transient currents away from sensitive LED and IC ... compared to Multilayer Varistors (MLV). All devices meet ...
(Date:2/27/2015)... 27, 2015 Those who ... often misunderstood, misdiagnosed and therefore aren’t receiving ... lives. Jacksonville-based addiction treatment center Lakeview ... highly acclaimed Lakeview Professional Lecture Series to ... understanding this complicated condition. , ...
Breaking Medicine News(10 mins):Health News:Mercy Harvard Hospital Recognized as Leader in Stroke Care - Javon Bea 2Health News:New Name Announced For Newest MedixSafe Readers – MedixSafe Vanguard 2Health News:1Heart Caregiver Services Showcases Emerging Brand at Franchise Expo South and IFA Annual Convention 2Health News:1Heart Caregiver Services Showcases Emerging Brand at Franchise Expo South and IFA Annual Convention 3Health News:OnChip Introduces New Series of Space Saving Bare-die Zener Diodes for Transient Voltage Suppression 2Health News:OnChip Introduces New Series of Space Saving Bare-die Zener Diodes for Transient Voltage Suppression 3Health News:Lakeview Health to Host Important Workshop Tackling the Rising Issue of ‘Cutters’ on March 27 2
... SectorWatch.biz announces the,availability of MarketStats on medical ... markets today. MarketStats offers a perspective on the,aforementioned ... with,articles and opinions on the subject and sector ... MarketStats by visiting: http://www.SectorWatch.biz ,-- a division ...
... -, MONTVALE, N.J., June 24 Memory,Pharmaceuticals Corp. ... secured $2,million through the sale of approximately 4.7 million ... an investment group led by,The Stanley Medical Research Institute ... tranche following the,achievement of a predefined milestone related to ...
... 24 The Southeastern Michigan,Blood Services Region of the ... is struggling to meet the requests of local hospitals. ... below minimum inventory,standards. Currently there is zero O-, the ... patients in 43 local hospitals, the Region should,maintain a ...
... June 24 AMDL, Inc. (Amex:,ADL), http://www.amdl.com, ... Ca. with operations in Shenzhen, Jiangxi, and,Jilin, China, ... video which,is available for viewing on the Company,s ... Gary Dreher, Chief Executive Officer of AMDL, "We ...
... help broaden market penetration in China, TUSTIN, ... http://www.amdl.com ), a leader in specialty pharmaceuticals,announced today ... the 3rd quarter of 2008 two new formulations ... In addition to its,high quality injectable formulation, JPI ...
... - Barr Plans to Launch Generic Yasmin(R) on or before ... Launch Generic Yaz(R) on or before July 1, 2011 ... Court Decision, MONTVALE, N.J., June 24 Barr Pharmaceuticals,Inc. ... subsidiary, Barr,Laboratories, Inc. has entered into supply and licensing agreements ...
Cached Medicine News:Health News:SectorWatch.biz Issues MarketStats on Medical Products and Device Companies INCC, CMED, WX, MR and AOB 2Health News:Memory Pharmaceuticals Closes Second Tranche of Equity Financing with The Stanley Medical Research Institute 2Health News:Memory Pharmaceuticals Closes Second Tranche of Equity Financing with The Stanley Medical Research Institute 3Health News:AMDL Announces New Corporate Video 2Health News:AMDL's Goodnak(R) Anti-Aging Skin Care Line Soon Available in Capsule & Lotion Form 2Health News:Barr and Bayer Sign Supply and Licensing Agreements for Launch of Generic Yasmin(R) and Yaz(R) Oral Contraceptives 2Health News:Barr and Bayer Sign Supply and Licensing Agreements for Launch of Generic Yasmin(R) and Yaz(R) Oral Contraceptives 3Health News:Barr and Bayer Sign Supply and Licensing Agreements for Launch of Generic Yasmin(R) and Yaz(R) Oral Contraceptives 4Health News:Barr and Bayer Sign Supply and Licensing Agreements for Launch of Generic Yasmin(R) and Yaz(R) Oral Contraceptives 5
(Date:2/27/2015)... 2015 Roughly three-quarters of pharmacists said ... an interchangeable biosimilar for its branded biologic counterpart ... name, according to a survey published in the ... of Managed Care & Specialty Pharmacy (JMCP). ... pharmacists would feel as confident if the products ...
(Date:2/27/2015)... 27, 2015 Pharmaceutical and biotech marketers are ... for the same indication. This can be a complex ... prevent one of their brands from gaining market share ... recent research by benchmarking firm, Best Practices, LLC, 75% ... rather than together as part of a franchise. Marketers ...
(Date:2/27/2015)... 27, 2015 The role of the Medical ... one thing hasn,t changed: face-to-face meetings are seen as ... Key Opinion Leaders. Yet at the same ... type of interaction, field medical teams within the pharmaceutical ... This is just one of the challenges addressed in ...
Breaking Medicine Technology:Survey Published in AMCP's JMCP Finds Pharmacists Are Most Confident Substituting Interchangeable Biosimilars for Brand Biologics When Products Share Nonproprietary Name 2New Report Details How to Expand a Pharmaceutical Product Portfolio without Cannibalizing an Established Brand 2Improving the Management of MSL Teams to Create Value across a Diverse Set of Customers 2
... Finn Revision Knee System ... distal femoral replacement options. The ... Finn Rotating Hinge Knee, promotes ... function and is designed for ...
The Advance stemmed medial-pivot knee is a revision knee that provides unique and competitive features....
... The NexGen Legacy LCCK Femoral Component ... additional prosthetic stabilization due to inadequate ... and require augmentation and/or stem extensions ... NexGen LCCK is available with a ...
The Duracon system provides superb articular conformity throughout the range of motion, reducing contact stresses generally associated with wear....
Medicine Products: