Navigation Links
New Insight Gained For Allergic Reactions

Researchers from University of Texas Medical Branch at Galveston have found that there may be an additional factor that may cause the allergic reactions// and asthma other than the body’s immune system reacting to the allergens.

This factor is the damage caused by chemically hyperactive molecules known as “reactive oxygen species,” which are spawned by interactions between a single pollen-carried enzyme and the cells that line airways. And, the researchers say, if an effective way can be found to reduce that damage—called “oxidative stress”—new and powerful allergy and asthma therapies may result.

The research is published in the recent issue of the Journal of Clinical Investigation.

The researchers had worked for nearly four years conducting extensive test-tube and lab-mouse experiments to prove the paradigm shifting “two-signal concept” in detail. They zeroed in on a key enzyme known as NADPH oxidase, which they identified in grains of pollen produced by ragweed and 38 other plant pollens and molds linked to allergy and asthma attacks. Within minutes of exposure, ragweed pollen or its extract containing NADPH oxidase produces damaging reactive oxygen species in cell culture and, in experiments with mice, in their lungs and airway lining fluid. The resulting oxidative stress almost immediately prompted the production of inflammatory immune signaling molecules and accumulation of inflammatory cells, a downstream event common to lung and other type of allergic inflammations. By contrast, ragweed pollen extract from which NADPH oxidase had been removed produced no reactive oxygen species, and resulted in a much smaller increase in numbers of inflammatory immune cells.

The research shows that it takes both oxidative stress and antigenic exposure to get a robust allergy or asthma attack, and also that the first few minutes of the exposure is critical. These two signals play a vital role in inducing allergic inflammation. '"/>




Page: 1 2

Related medicine news :

1. fMRI Offers Insight Into An Infants Brain
2. New Insight To The Role Of Peptide Signals
3. Insight for Hot Flashes In Postmenopausal Women
4. New Insight In Periodontal Disease In Postmenopausal Women
5. Researchers Bring New Insight To Asthma And SABA Fills
6. Study Unveils New Insight To The Madness Of King George III
7. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
8. Reindeer Provide Valuable Insights Into Sleep Disorders
9. Insight Into The Risky Health Decisions On Bird Flu
10. Cure Insight for DMD
11. Insights Into Lead Pollution
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Insight Gained For Allergic Reactions

(Date:7/23/2014)... Steven Reinberg HealthDay Reporter ... obese and overweight American children and teens look in ... U.S. health officials reported Wednesday. "Being overweight or ... high blood pressure, high cholesterol and diabetes," said lead ... Centers for Disease Control and Prevention,s National Center for ...
(Date:7/23/2014)... AB (PRWEB) July 23, 2014 ... of in-home care for seniors, is proud to announce ... Series featuring experts in a wide range of health ... clinical social worker and award-winning author Nancy Kriseman, and ... and ways to prevent burnout by becoming more self-aware. ...
(Date:7/23/2014)... body of research suggesting a safe and effective ... breast cancer, with fewer detrimental side effects and ... The study will be published in final format ... and Endocrinology . , Breast cancer is the ... United States. Approximately 70% of breast cancers are ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 The ... ATA 2015, ATA’s twentieth annual meeting and tradeshow ... meeting, expected to attract over 5,000 attendees and ... take place May 3-5, 2015, in Los Angeles. ... renowned healthcare technology professionals from researchers, clinicians, hospital ...
(Date:7/23/2014)... syndrome ( FXS ) is a genetic disorder that ... the autistic spectrum, as well as cognitive deficits. It ... and the most common cause of autism. , Now ... published a study that sheds light on ... today (July 23) in the Journal of Neuroscience ...
Breaking Medicine News(10 mins):Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 2Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 3Health News:Home Care Assistance Calgary to Host Public Webinar on the Topic of Caregiver Mindfulness 2Health News:Home Care Assistance Calgary to Host Public Webinar on the Topic of Caregiver Mindfulness 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 4Health News:Hormones after breast cancer: Not fuel for the fire after all? 5Health News:ATA Seeks Speakers to Present at the World’s Largest Telemedicine, mHealth and Telehealth Conference 2Health News:Study links enzyme to autistic behaviors 2Health News:Study links enzyme to autistic behaviors 3
... estimates that about 30 per cent of Americans report have some ... Over half (17.8 per cent) are due to alcohol abuse ... that 1 out 3 persons in the US have a real ... this problem can vary widely -- from a sustained streak of ...
... for thousands of years in High Artic are drying up ... ponds in the Arctic drying up during the polar summer ... rapid effects of global warming, threatening bird habitats and breeding ... Smol of Queens University in Kingston, Ontario, and Marianne S. ...
... President Hugo Chavez has threatened to nationalise private hospitals if ... ,Chavez made a nationally televised speech, saying that the privately ... public health service if they failed to abide by the ... as a symptom of "the evil of capitalism", which allow ...
... cleaning septic tanks trapped by methane gas is commonplace in ... catching up in the West too. Fiver persons fell victims ... a dairy farm in Shenandoah Valley, Virginia, US Monday evening. ... into the pit to unclog a pipe was the first ...
... According to new figures presented at the European Society ... , Germanys embryo protection law has had the unintended ... fertility treatment. , ,The German embryo protection law, ... embryos can be created per cycle of IVF and ...
... decree on the state MENA news agency on Tuesday outlawing ... submit a total ban to parliament. ,"The traditional ... because of the compelling evidence of the extensive damage it ... by the office of the mufti, Sheikh Ali Gomaa. ...
Cached Medicine News:Health News:Drinking Problem Plagues 30% Americans 2Health News:Drinking Problem Plagues 30% Americans 3Health News:Pond in High Artic Drying Up Due to Global Warming 2Health News:Five Killed by Methane Gas on Virginia Farm 2Health News:Five Killed by Methane Gas on Virginia Farm 3Health News:Embryo Protection Law in Germany 2Health News:Embryo Protection Law in Germany 3Health News:Embryo Protection Law in Germany 4
(Date:7/23/2014)...  The management team at Columbia Laboratories, Inc. ... conference call on July 31, 2014, to discuss ... 30, 2014.  The call details are as follows:Date: ... EDTDial-in numbers: , Toll free: (877) 870-4263 (U.S.), ... archive): , www.columbialabs.com , under ,Investor, or ...
(Date:7/23/2014)... , July 23, 2014  Silk Road ... the transcarotid treatment of intra- and extra-cranial cerebrovascular ... P. Wallace to the position of Chief ... lead the company,s Research and Development efforts across ... Prior to joining Silk Road ...
(Date:7/23/2014)... YORK , July 23, 2014  Dompe, a leader ... rare diseases, announces that rhNGF (Recombinant Human Nerve Growth Factor) ... Food and Drug Administration (FDA). The candidate ... as an orphan drug for the treatment of neurotrophic keratitis, ... 5,000 people 1 and is currently without a cure. ...
Breaking Medicine Technology:Columbia Laboratories to Discuss Second Quarter 2014 Financial Results on July 31st Conference Call 2Silk Road Medical Appoints Ground Breaking Innovator as Chief Technology Officer 2Silk Road Medical Appoints Ground Breaking Innovator as Chief Technology Officer 3Dompe announces the Food and Drug Administration (FDA) has granted orphan drug designation to its rhNGF-based treatment for neurotrophic keratitis 2Dompe announces the Food and Drug Administration (FDA) has granted orphan drug designation to its rhNGF-based treatment for neurotrophic keratitis 3Dompe announces the Food and Drug Administration (FDA) has granted orphan drug designation to its rhNGF-based treatment for neurotrophic keratitis 4
... April 13, 2011 ThermoGenesis Corp. (NASDAQ: ... that process and store adult stem cells, said today that ... Central Drugs Standard Control Organization of India (CDSCO), allowing its ... care system used for the preparation of cell concentrates, including ...
... 2011 Medco Health Solutions, Inc. (NYSE: MHS ... a press release before the market opens on Thursday, April ... the release, management will hold a conference call to review ... ET.   To access the live conference ...
Cached Medicine Technology:ThermoGenesis Announces Registration of Res-Q in India; Commercial Sales Expected to Begin in Current Quarter 2ThermoGenesis Announces Registration of Res-Q in India; Commercial Sales Expected to Begin in Current Quarter 3ThermoGenesis Announces Registration of Res-Q in India; Commercial Sales Expected to Begin in Current Quarter 4Medco Announces Date for Release of First-Quarter 2011 Financial Results 2
Arthrex has the most extensive offering of arthroscopic suture passing instruments,available anywhere in the world. We have speci? cally designed the function of our,instruments to work hand in hand ...
Arthrex has the most extensive offering of arthroscopic suture passing instruments,available anywhere in the world. We have speci? cally designed the function of our,instruments to work hand in hand ...
... The Shuttle Relay Suture Passer allows braided ... tissue repair procedures. It may be ... suture material and in conjunction with anchors ... anchor) Additionally, the Shuttle Relay can ...
... EMR Electronic Medical Record organizes communication ... and with outside practitioners. It also ... and other data that traditionally rely ... the patient chart. With Microsoft Outlook ...
Medicine Products: