Navigation Links
New Insight Gained For Allergic Reactions

Researchers from University of Texas Medical Branch at Galveston have found that there may be an additional factor that may cause the allergic reactions// and asthma other than the body’s immune system reacting to the allergens.

This factor is the damage caused by chemically hyperactive molecules known as “reactive oxygen species,” which are spawned by interactions between a single pollen-carried enzyme and the cells that line airways. And, the researchers say, if an effective way can be found to reduce that damage—called “oxidative stress”—new and powerful allergy and asthma therapies may result.

The research is published in the recent issue of the Journal of Clinical Investigation.

The researchers had worked for nearly four years conducting extensive test-tube and lab-mouse experiments to prove the paradigm shifting “two-signal concept” in detail. They zeroed in on a key enzyme known as NADPH oxidase, which they identified in grains of pollen produced by ragweed and 38 other plant pollens and molds linked to allergy and asthma attacks. Within minutes of exposure, ragweed pollen or its extract containing NADPH oxidase produces damaging reactive oxygen species in cell culture and, in experiments with mice, in their lungs and airway lining fluid. The resulting oxidative stress almost immediately prompted the production of inflammatory immune signaling molecules and accumulation of inflammatory cells, a downstream event common to lung and other type of allergic inflammations. By contrast, ragweed pollen extract from which NADPH oxidase had been removed produced no reactive oxygen species, and resulted in a much smaller increase in numbers of inflammatory immune cells.

The research shows that it takes both oxidative stress and antigenic exposure to get a robust allergy or asthma attack, and also that the first few minutes of the exposure is critical. These two signals play a vital role in inducing allergic inflammation.

Because antioxidant compounds are quickly metabolized in the lungs and airways, it may be necessary to deliver them every few hours via an inhaler. Researchers have suggested that it is now important to develop longer-lived antioxidants.

Source: Newswise

Medindia on Asthma: Further information

Asthma: Asthma is the condition of affected airways that restrict the airflow to the lungs. People suffering from asthma have their air passages always inflamed and sensitive to outside irritants that set off the allergic reactions of narrowing the air passage that makes it difficult to breathe.

For more information read:

http://www.medindia.net/patients
/patientinfo/asthma_info.htm

'"/>




Related medicine news :

1. fMRI Offers Insight Into An Infants Brain
2. New Insight To The Role Of Peptide Signals
3. Insight for Hot Flashes In Postmenopausal Women
4. New Insight In Periodontal Disease In Postmenopausal Women
5. Researchers Bring New Insight To Asthma And SABA Fills
6. Study Unveils New Insight To The Madness Of King George III
7. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
8. Reindeer Provide Valuable Insights Into Sleep Disorders
9. Insight Into The Risky Health Decisions On Bird Flu
10. Cure Insight for DMD
11. Insights Into Lead Pollution
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension ... that it will receive two significant new grants to support its work to ... its 25th anniversary by recognizing patients, medical professionals and scientists for their work ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented ... in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- , , , WHEN: , ... , , , LOCATION: , , , Online, with free ... EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice President ... Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... is witnessing an exceptional era. Several new demand spaces, such as ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... environments  Oticon , industry leaders in ... the launch of Oticon Opn ™, the world,s ... world of possibilities for IoT devices.      ... Opn, Oticon introduces a number of ,world firsts,: ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Volumes: Global Analysis (United States, China, Japan, Brazil, United ... to their offering. ... healthcare business planners, provides surgical procedure volume data in ... with an in-depth analysis of growth drivers and inhibitors, ...
Breaking Medicine Technology: