Navigation Links
New Insight Gained For Allergic Reactions

Researchers from University of Texas Medical Branch at Galveston have found that there may be an additional factor that may cause the allergic reactions// and asthma other than the body’s immune system reacting to the allergens.

This factor is the damage caused by chemically hyperactive molecules known as “reactive oxygen species,” which are spawned by interactions between a single pollen-carried enzyme and the cells that line airways. And, the researchers say, if an effective way can be found to reduce that damage—called “oxidative stress”—new and powerful allergy and asthma therapies may result.

The research is published in the recent issue of the Journal of Clinical Investigation.

The researchers had worked for nearly four years conducting extensive test-tube and lab-mouse experiments to prove the paradigm shifting “two-signal concept” in detail. They zeroed in on a key enzyme known as NADPH oxidase, which they identified in grains of pollen produced by ragweed and 38 other plant pollens and molds linked to allergy and asthma attacks. Within minutes of exposure, ragweed pollen or its extract containing NADPH oxidase produces damaging reactive oxygen species in cell culture and, in experiments with mice, in their lungs and airway lining fluid. The resulting oxidative stress almost immediately prompted the production of inflammatory immune signaling molecules and accumulation of inflammatory cells, a downstream event common to lung and other type of allergic inflammations. By contrast, ragweed pollen extract from which NADPH oxidase had been removed produced no reactive oxygen species, and resulted in a much smaller increase in numbers of inflammatory immune cells.

The research shows that it takes both oxidative stress and antigenic exposure to get a robust allergy or asthma attack, and also that the first few minutes of the exposure is critical. These two signals play a vital role in inducing allergic inflammation.

Because antioxidant compounds are quickly metabolized in the lungs and airways, it may be necessary to deliver them every few hours via an inhaler. Researchers have suggested that it is now important to develop longer-lived antioxidants.

Source: Newswise

Medindia on Asthma: Further information

Asthma: Asthma is the condition of affected airways that restrict the airflow to the lungs. People suffering from asthma have their air passages always inflamed and sensitive to outside irritants that set off the allergic reactions of narrowing the air passage that makes it difficult to breathe.

For more information read:

http://www.medindia.net/patients
/patientinfo/asthma_info.htm

'"/>




Related medicine news :

1. fMRI Offers Insight Into An Infants Brain
2. New Insight To The Role Of Peptide Signals
3. Insight for Hot Flashes In Postmenopausal Women
4. New Insight In Periodontal Disease In Postmenopausal Women
5. Researchers Bring New Insight To Asthma And SABA Fills
6. Study Unveils New Insight To The Madness Of King George III
7. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
8. Reindeer Provide Valuable Insights Into Sleep Disorders
9. Insight Into The Risky Health Decisions On Bird Flu
10. Cure Insight for DMD
11. Insights Into Lead Pollution
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... ambulance transport experience for the millions of people who require these medical transport ... taxi industry through the use of technology. Now, SmartEMS has put forth an ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media ... give their videos a whole new perspective by using the title layers in ... Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... report to their offering. ... favourable commercial environment for MedImmune to enter. The US ageing ... serve to drive considerable growth for effective anti-influenza medications. The ... sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
(Date:6/23/2016)... 23, 2016  Guerbet announced today that it has ... Horizon Award . One of 12 suppliers ... for its support of Premier members through exceptional local ... and commitment to lower costs. ... of our outstanding customer service from Premier," says ...
Breaking Medicine Technology: