Navigation Links
New Insight Gained For Allergic Reactions

Researchers from University of Texas Medical Branch at Galveston have found that there may be an additional factor that may cause the allergic reactions// and asthma other than the body’s immune system reacting to the allergens.

This factor is the damage caused by chemically hyperactive molecules known as “reactive oxygen species,” which are spawned by interactions between a single pollen-carried enzyme and the cells that line airways. And, the researchers say, if an effective way can be found to reduce that damage—called “oxidative stress”—new and powerful allergy and asthma therapies may result.

The research is published in the recent issue of the Journal of Clinical Investigation.

The researchers had worked for nearly four years conducting extensive test-tube and lab-mouse experiments to prove the paradigm shifting “two-signal concept” in detail. They zeroed in on a key enzyme known as NADPH oxidase, which they identified in grains of pollen produced by ragweed and 38 other plant pollens and molds linked to allergy and asthma attacks. Within minutes of exposure, ragweed pollen or its extract containing NADPH oxidase produces damaging reactive oxygen species in cell culture and, in experiments with mice, in their lungs and airway lining fluid. The resulting oxidative stress almost immediately prompted the production of inflammatory immune signaling molecules and accumulation of inflammatory cells, a downstream event common to lung and other type of allergic inflammations. By contrast, ragweed pollen extract from which NADPH oxidase had been removed produced no reactive oxygen species, and resulted in a much smaller increase in numbers of inflammatory immune cells.

The research shows that it takes both oxidative stress and antigenic exposure to get a robust allergy or asthma attack, and also that the first few minutes of the exposure is critical. These two signals play a vital role in inducing allergic inflammation.

Because antioxidant compounds are quickly metabolized in the lungs and airways, it may be necessary to deliver them every few hours via an inhaler. Researchers have suggested that it is now important to develop longer-lived antioxidants.

Source: Newswise

Medindia on Asthma: Further information

Asthma: Asthma is the condition of affected airways that restrict the airflow to the lungs. People suffering from asthma have their air passages always inflamed and sensitive to outside irritants that set off the allergic reactions of narrowing the air passage that makes it difficult to breathe.

For more information read:

http://www.medindia.net/patients
/patientinfo/asthma_info.htm

'"/>




Related medicine news :

1. fMRI Offers Insight Into An Infants Brain
2. New Insight To The Role Of Peptide Signals
3. Insight for Hot Flashes In Postmenopausal Women
4. New Insight In Periodontal Disease In Postmenopausal Women
5. Researchers Bring New Insight To Asthma And SABA Fills
6. Study Unveils New Insight To The Madness Of King George III
7. Study Offers Insights Into Treatment Of Rheumatoid Arthritis
8. Reindeer Provide Valuable Insights Into Sleep Disorders
9. Insight Into The Risky Health Decisions On Bird Flu
10. Cure Insight for DMD
11. Insights Into Lead Pollution
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... Therachat ... its new survey in an infographic on the current state of anxiety in support ... familiar with anxiety, was conducted in April 2017 and benchmarked general anxiety levels as ...
(Date:5/22/2017)... ... May 22, 2017 , ... Dr. Kiya Green, a ... periodontal plastic surgery treatments, including crown lengthening and gum reduction surgery, ... esthetic and functional procedures to help patients improve their oral health, reduce gummy ...
(Date:5/22/2017)... Galena, Alaska (PRWEB) , ... May 22, 2017 , ... ... town near the Arctic Circle made big headlines when it was targeted to build ... Low-Cost Energy in Bush Alaska,” former city manager Marvin L. Yoder describes the journey ...
(Date:5/21/2017)... ... , ... Chris Cornell, 52, was found dead on the night of Wednesday, May 17, 2017. ... singers in the rock industry would take his own life, but the extremely talented and ... illness played a role in the death of Chris Cornell . , Depression and ...
(Date:5/21/2017)... (PRWEB) , ... May 20, 2017 , ... Pot. Reefer. ... find it, review it, and share its attributes like never before. More than a ... to connect cannabis enthusiasts to stores, strains, products – and for the first time ...
Breaking Medicine News(10 mins):
(Date:5/22/2017)... 22, 2017  As the specialty pharmacy industry ... to make the revolutionary shift from volume-based to ... ensuring positive patient outcomes and shaping the future ... focus away from clinical trials and toward data ... specialty drug therapy utilization in precise patient populations. ...
(Date:5/18/2017)... May 17, 2017  Bayer announced today that the ... be presented at the 53 rd Annual Meeting ... place June 2-6 in Chicago . ... span prostate, colorectal, liver and thyroid cancers, as well ... Phase II CHRONOS-1 trial of copanlisib in patients with ...
(Date:5/15/2017)... PHILADELPHIA , May 15, 2017 Enterin Inc., ... and developing novel compounds to treat Parkinson,s disease ... The study is a Phase 1/2a randomized, controlled, multicenter study ... sites. It will enroll 50 patients over a 9-to-12-month period. ... doses in 10 patients with PD. Participating sites include ...
Breaking Medicine Technology: