Navigation Links
New Hope for Kidney Failure

A recently discovered molecule may have the potential to protect the kidneys from failing after injury, according to new research.//

For the study, mice were genetically engineered to express higher-than-normal levels of the natural molecule hepatic growth factor (HGF) or another natural factor called parathyroid hormone-related protein (PTHrP). Both groups of mice developed normal kidney functions, thus allowing the researchers to study how the high levels of HGF and PTHrP would affect kidney recovery after blood flow to the kidney was temporarily interrupted.

Scientists found the mice that had not been genetically modified had their kidney functions sharply reduced, and the function worsened over time following the reduction in blood supply. In contrast, the mice with higher levels of HGF experienced a much lower degree of kidney damage after injury. Two days later, their kidney functions had almost completely returned to normal. Mice with high levels of HGF were also much more likely to survive after kidney injuries than mice with normal levels.

Kidney failure commonly occurs in intensive care units following a major surgery, and currently, patients who experience it have a mortality rate of about 50 percent. The researchers say it is a major cause of death in seriously ill patients. They explain acute renal failure -- or kidney failure -- occurs because of renal tubule cell death. When the researchers examined the kidneys of the genetically modified mice, they discovered the high level of HGF actually protected the renal tubule cells. These cells play an important role in the kidney's ability to produce urine.

Researchers write, "The fact that the kidneys developed normally in high-HGF and high-PTHrP mice is an important step forward in assessing the protective effects of these factors against cell damage." They call it "remarkable" that the HGF does not seem to negatively affect kidney development, yet it has a "stri king protective effect" against kidney failure.

"We conclude that gene delivery of HGF to the proximal tubule may be an interesting approach in designing future strategies aimed at the treatment and prevention of [acute renal failure]," they write.


Related medicine news :

1. Is Diabetes the Leading Cause of Kidney Failure in India
2. Kidney Stones - Interesting New Research implicates bacteria as its cause
3. Moderate Use of Analgesics - Not Associated With Kidney Dysfunction
4. New Dietary Approach To Manage Kidney Stones
5. Kidney cancer on the rise
6. Kidney function can be affected by lead exposure
7. Kidney Failure after Non-Kidney Transplants
8. Kidney Patients Risk Heart Attacks
9. Kidney Patients Risk Heart Attacks
10. Urine Test for Kidney Cancer
11. Hope for Patients With Kidney Failure
Post Your Comments:

(Date:11/26/2015)... ... 26, 2015 , ... The Catalent Applied Drug Delivery Institute ... integrate dose form selection in early phase drug development. The first of these ... bringing together the UK’s emerging life sciences companies, corporate partners, and investors, at ...
(Date:11/26/2015)... , ... November 26, 2015 ... ... platform for mental health and wellness consultation, has collaborated with Women’s Web ... address their reader’s queries on topics on mental and emotional well-being relationship, ...
(Date:11/25/2015)... ... ... Finnleo, a leader in the traditional and far-infrared sauna industry, announced a ... , For traditional saunas, Finnleo is offering 20% off all Nordic ... uses only European Grade A Nordic White Spruce from sustainably grown trees. Because of ...
(Date:11/25/2015)... Rouge, LA (PRWEB) , ... November 25, 2015 , ... ... in the United States District Court of Connecticut on behalf of a home health ... behalf of all current or former home health care workers employed by Humana, Inc., ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 25, 2015, officials of ... network, announced the release of a new cutting edge recovery program that has been ... working with drug- and alcohol-addicted individuals with the purpose to free addicts from the ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... november 2015 AAIPharma Services Corp./Cambridge ... investering aan van ten minste $15,8 miljoen ... het mondiale hoofdkantoor in Wilmington, ... in extra kantoorruimte en extra capaciteit voor ... behoeften van de farmaceutische en biotechnologische markten. ...
(Date:11/26/2015)... 2015 --> ... combineert immunotherapie met Bremachlorin-photodynamische therapie voor de ... ) --> ... ) Uit een ... (LUMC) blijkt dat ...
(Date:11/26/2015)... DUBLIN , Nov. 26, 2015 Research and ... "Asia Pacific Cardiac Pacemaker Market Outlook to 2019 - ... Drive the Demand " report to their offering. ... --> Boston scientific and others. ... global players including Medtronic, Biotronik, Boston ...
Breaking Medicine Technology: