Navigation Links
New Hope for Kidney Failure

A recently discovered molecule may have the potential to protect the kidneys from failing after injury, according to new research.//

For the study, mice were genetically engineered to express higher-than-normal levels of the natural molecule hepatic growth factor (HGF) or another natural factor called parathyroid hormone-related protein (PTHrP). Both groups of mice developed normal kidney functions, thus allowing the researchers to study how the high levels of HGF and PTHrP would affect kidney recovery after blood flow to the kidney was temporarily interrupted.

Scientists found the mice that had not been genetically modified had their kidney functions sharply reduced, and the function worsened over time following the reduction in blood supply. In contrast, the mice with higher levels of HGF experienced a much lower degree of kidney damage after injury. Two days later, their kidney functions had almost completely returned to normal. Mice with high levels of HGF were also much more likely to survive after kidney injuries than mice with normal levels.

Kidney failure commonly occurs in intensive care units following a major surgery, and currently, patients who experience it have a mortality rate of about 50 percent. The researchers say it is a major cause of death in seriously ill patients. They explain acute renal failure -- or kidney failure -- occurs because of renal tubule cell death. When the researchers examined the kidneys of the genetically modified mice, they discovered the high level of HGF actually protected the renal tubule cells. These cells play an important role in the kidney's ability to produce urine.

Researchers write, "The fact that the kidneys developed normally in high-HGF and high-PTHrP mice is an important step forward in assessing the protective effects of these factors against cell damage." They call it "remarkable" that the HGF does not seem to negatively affect kidney development, yet it has a "stri king protective effect" against kidney failure.

"We conclude that gene delivery of HGF to the proximal tubule may be an interesting approach in designing future strategies aimed at the treatment and prevention of [acute renal failure]," they write.


'"/>




Related medicine news :

1. Is Diabetes the Leading Cause of Kidney Failure in India
2. Kidney Stones - Interesting New Research implicates bacteria as its cause
3. Moderate Use of Analgesics - Not Associated With Kidney Dysfunction
4. New Dietary Approach To Manage Kidney Stones
5. Kidney cancer on the rise
6. Kidney function can be affected by lead exposure
7. Kidney Failure after Non-Kidney Transplants
8. Kidney Patients Risk Heart Attacks
9. Kidney Patients Risk Heart Attacks
10. Urine Test for Kidney Cancer
11. Hope for Patients With Kidney Failure
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 million ... by frequent cessation in breathing. Oral appliances can offer significant relief to about ...
(Date:10/12/2017)... CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... cold therapy products, announced today the introduction of an innovative new design of the ... multipurpose pad so you get maximum comfort while controlling your pain while using cold ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... that we intend to develop to enable prevention of a major side effect ... hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will ... the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey ... Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations (HLI), creator ... tool, and the Cancer Patient Education Network (CPEN), an independent professional organization that ... new strategic alliance. , As CPEN’s strategic partner, HLI will help support ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... its MyDario product is expected to appear on The Dr. Oz Show ... Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show kicked off ... The segment features ...
(Date:9/22/2017)... 2017 AVACEN Medical (AVACEN) announced that its ... helping those with the widespread pain associated with fibromyalgia ... in Essex, England commented, "I ... experiencing no sleep at all, tremendous pain, with every ... recommend [the AVACEN 100] enough, how this has and ...
(Date:9/13/2017)... OrthoAtlanta has been named the official orthopedic and sports ... the 2018 College Football Playoff (CFP) National Championship to be ... Atlanta, Georgia . OrthoAtlanta is proud to ... in many activities leading up to, and including the national ... OrthoAtlanta ...
Breaking Medicine Technology: