Navigation Links
New Hair in 15 Days Could Now Be A Possibility Say Researchers

Adult hair follicles undergo a growth cycle consisting of periods of growth (anagen), regression (catagen), and rest (telogen). Researchers demonstrated that the brief activation of ?-catenin in // telogen-phase adult hair follicles is sufficient to initiate the anagen phase. Scientists have discovered that the transient activation of a protein called ?-catenin can induce new hair growth.

Previous work has implicated Wnt/?-catenin signaling in embryonic hair follicle development, postnatal follicle growth and maturation, and skin tumor formation. This new work provides important insight into the role of ?-catenin as a trigger for activating the normal growth of adult hair follicles.

Researchers generated transgenic mice expressing an inactive version of ?-catenin in their skin and hair follicles. Upon topical treatment of the mice with a chemical called 4-OHT, the exogenous ?-catenin protein is activated. Thus, through the cutaneous application of 4-OHT, the researchers could transiently activate ?-catenin signaling at will.

To test the effect of ?-catenin signaling on adult hair growth, the researchers shaved the backs of telogen-phase transgenic and wild-type mice, and then applied 4-OHT once. Within 15 days, the transgenic mice grew new hair, whereas wild-type still had none . Furthermore, the new hair was histologically indistinguishable from normal hair, and progressed through the remainder of the growth cycle in stereotypical fashion.

It was found that brief activation of ?-catenin in resting hair follicles is sufficient to trigger a normal follicle growth phase, followed by the expected regression and resting phases. ?-catenin acts specifically on epithelial hair follicle progenitor cells, triggering a highly coordinated program of proliferation followed by expansion into the multiple differentiated cell types that comprise the mature, growing hair follicle. In contrast to the effects of transient and regulated beta-cat enin activation, prolonged activation of ?-catenin leads to uncontrolled growth and gross distortion of the hair follicle structure, underscoring the importance of precisely controlled signaling activity for normal follicle regeneration.

Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Nasal Spray Could Take Drugs Direct to Brain.
3. Nasal Spray Could Take Drugs Directly to Brain
4. Oxygen Usage During Exercise Could Indicate Heart Problems
5. Ultrasound Screening Could Improve The Outcome Of Critically ill Patients
6. Anger Could Be Linked To Weight Gain
7. A Seizure Late In Life Could be A Stroke Warning
8. New Findings Could Reduce The Extent Of Spinal Cord Injuries
9. Could There Be A Link Between Famine and Breast Cancer ?
10. Bone Marrow Cells Could Yield A New Lease of Life
11. Your Wheezing Could be Due To Your Bed
Post Your Comments:

(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... ... to fertility once they have been diagnosed with endometriosis. These women need a ... they also require a comprehensive approach that can help for preservation of fertility ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from reveals that behind the tendency ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 VolitionRx ... of Dr. Edward Futcher to the ... effective June 23, 2016.Dr. Futcher was also appointed ... Governance Committees.  As a non-executive member of the ... and strategic counsel to VolitionRx in connection with ...
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
(Date:6/23/2016)... 2016 Any dentist who has made an implant ... process. Many of them do not even offer this as ... high laboratory costs involved. And those who ARE able to ... a high cost that the majority of today,s patients would ... Parsa Zadeh , founder of Dental Evolutions Inc. and inventor ...
Breaking Medicine Technology: