( n the conventional assessment will now...)New Guidelines For Assessing Lymphoma Treatment,Health

n the conventional assessment, will now be considered in complete response if their PET scan is negative. Such patients can be safely observed and are expected to have an excellent outcome," Juweid said.

In contrast, Juweid added, the smaller fraction of such patients who are PET-positive after treatment should undergo a biopsy to evaluate the PET-positive lesion unless there already is other compelling clinical and/or biochemical suspicion of persistent disease. If the biopsy is positive, these patients can rapidly be considered for salvage therapy.

The revised guidelines cover the use of PET for assessing all types of lymphoma. For two potentially curable types of lymphoma, DLBCL and Hodgkin's disease, the guidelines recommend that PET always be used to assess post-treatment response. PET also is strongly recommended prior to treatment to determine extent of disease for these lymphomas.

For the other 30 or so other subtypes of lymphoma, most of which are less common, the guidelines offer recommendations for when PET is useful and when it is not, and if PET is used in those cases, what criteria should be fulfilled.

The guidelines also address when a scan should be performed and recommend that PET obtained for response assessment at therapy conclusion be done preferably six to eight weeks after completion of chemotherapy and eight to twelve weeks after radiation. Timing is important because inflammation, which is present in the early weeks following treatment of the tumor, can cause false positive PET scans.

Juweid added that adherence to the guidelines could improve medical practice by minimizing inappropriate practice variation, which should improve patient care.

Source-Newswise
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