( uven Belgium. This is the first...)New Guidelines For Assessing Lymphoma Treatment,Health

uven, Belgium.

"This is the first time that standardized guidelines have been recommended on an international level," Juweid said. "These revised criteria for response assessment of lymphoma are unique in that they are the first for any cancer type to formally integrate functional imaging with PET into the more conventional response assessment using clinical, laboratory and radiological measures."

Juweid is a co-author and principal imaging author of the paper outlining the IHP recommendations. He also is senior author of a second paper in the Jan. 22 online issue of the Journal of Clinical Oncology, which details the integration of PET into lymphoma response assessment.

PET is a non-invasive imaging technique that uses radioactivity emitted from injected tracer chemicals to measure and image biological activity. The most commonly used PET radiotracer is fluorodeoxyglucose (FDG), a radiolabeled form of glucose, which is consumed more avidly by tumors than by normal tissue.

In contrast to conventional computed tomography (CT) or magnetic resonance imaging (MRI), PET is able to distinguish between viable tumor and non-cancerous scar tissue that is often left behind after successful treatment of lymphoma. Incorporation of PET imaging into response assessment means that doctors can more accurately determine the nature of any residual mass and essentially rule out persistent cancer within the mass if the scan is PET-negative. This approach will allow researchers to accurately assess how well anti-lymphoma drugs work even when there is a residual mass at the tumor site following treatment.

Adoption of the revised guidelines is expected to have major implications for patient management, says Juweid.

"Many patients with either diffuse large B-cell lymphoma (DLBCL), which is the most common subtype of lymphoma, or Hodgkin's disease, who were previously considered in partial response to treatment based o
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