Navigation Links
New Generation Clinical Trials Could Save Time And Money, Improve Patient Care

In this era of personalized medicine, one should reevaluate new medicines and treatments for cancer, says Prof. Donald Berry//, Ph.D.,

Dr. Berry, professor and chair of the Department of Biostatistics and Applied Mathematics at The University of Texas M. D. Anderson Cancer Center, sees a need to rethink how clinical trials are designed and conducted in the U.S. He thinks the current 50-year-old system, will not be able to cope with the strain of 21st century medicine, and something should be done to relieve that strain.

Berry outlines his new approach to clinical trials in the January 2006 issue of Nature Reviews Drug Discovery. In the article, he advocates that the statistical method used to evaluate new drugs be turned on its head. He says the statistical method used nearly exclusively to design and monitor clinical trials today—a method called frequentist or Neyman-Pearson (for the statisticians who advocated its use)—is so narrowly focused and rigorous in its requirements that it limits innovation and learning.

The solution, which he has advocated for over 30 years, is to adopt a system called the Bayesian method, a statistical approach he says is more in line with how science works. He sites examples of Bayesian approaches being used routinely in physics, geology and other sciences. And he is putting his approach to the test at M. D. Anderson, where over 100 cancer-related phase I and II clinical trials are being planned or carried out using the Bayesian approach.

The main difference between the Bayesian approach and the frequentist approach to clinical trials is how each method deals with uncertainty, an inescapable component of any clinical trial. Unlike frequentist methods, Bayesian methods assign anything unknown a probability using information from previous experiments, explains Berry. In other words, Bayesian methods make use of the results of previous experiments, whereas frequentist approaches assume we have no
'"/>




Page: 1 2

Related medicine news :

1. Hearing Problems Of Middle Age Are Affecting The Younger Generation
2. Tigecycline – New Generation Tetracycline With Broad Spectrum Antibacterial Activit
3. Newer Generation Sleeping Pills Lack Superior Performance
4. Moles Among The Older Generation May Be Dangerous
5. Leptin, The Next Generation Antidepressant?
6. Generation Scotland To Examine Relation Between Lifestyle, Genetics and Health
7. Baby Gloom: ‘Baby Gap’ Generation Signals Babies’ Days Ot!
8. Researchers Aim To Develop Next Generation Of Surgical Robots
9. New Generation Teenagers Addiction to Prescription Drugs
10. New Generation - Medicinal Products
11. Take Third Generation Oral Contraceptives Off the Shelves-consumer Group Insists
Post Your Comments:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... lowers risk of further injury , , THURSDAY, Oct. 23 (HealthDay ... first step in saving a life after a sudden cardiac ... the Oct. 23 issue of Circulation , said that ... the losing the patient to the original cause of the ...
... Blogs and a Supportive Online Community for Personal, Social & Global ... ... 23 Whether you want to find,balance in your life, be a ... site, Intent.com, can help you achieve your,aspirations. Featuring a supportive community of ...
... 23 With the,number of visitors to Internet drug ... patients, health is higher than ever. Based on its,assessment ... the National Association of Boards of Pharmacy(R) (NABP(R)) finds,that ... of compliance with state,and federal laws or established patient ...
... Driver Carl Edwards Tours Facility; Meets with Patients, ... his No. 99 Aflac Ford Fusion show car in ... of Children,s Healthcare of Atlanta at,Egleston while he toured ... tour, a special ribbon-cutting ceremony was held to,unveil the ...
... USC/Norris Comprehensive Cancer,Center announced that Judy and Larry ... the USC/Norris Comprehensive Cancer Center, Keck School of,Medicine ... and Larry Freeman Cancer,Day Hospital, an outpatient facility ... Cancer Hospital. Larry Freeman is the founder of ...
... 2008,at 8:30am, a small yet energetic group ran or walked ... ). The,weather was perfect with a bright sun and no ... a 5K race or walk. "It was great to,see these ... the past," said Eric Su, owner of Goality and the ...
Cached Medicine News:Health News:Speedy Care After Heart Attack Key to Survival 2Health News:Intent.com Launches Premier Wellness Site & Social Network 2Health News:NABP Findings Underscore Dangers of Purchasing Prescription Medicine Online and From Foreign Sources 2Health News:NABP Findings Underscore Dangers of Purchasing Prescription Medicine Online and From Foreign Sources 3Health News:Aflac Cancer Center and Blood Disorders Service Unveils New Carl Edwards Triage Room 2Health News:Aflac Cancer Center and Blood Disorders Service Unveils New Carl Edwards Triage Room 3Health News:USC Cancer Center Announces Contribution By Larry and Judy Freeman 2
(Date:12/22/2014)... Tenn. , Dec. 22, 2014   TRU-D ... automated, no-touch UV disinfection robot, announced today that the ... Schedule contract through November 2019.   This ... rapidly engage all levels of government purchasers, including Department ... as well as Homeland Security contacts purchasing solutions for ...
(Date:12/22/2014)... Cyberonics, Inc. (NASDAQ: CYBX ), a ... of epilepsy, today announced it will participate in the 33 ... 14, 2015, in San Francisco . ... Officer, will speak at 11:00 AM Pacific Time.  A live ... on the Investor Relations link on the Cyberonics home page ...
(Date:12/22/2014)... , Dec. 22, 2014  Mark Farrah ... brief providing a summary of the 2015 marketplace ... enrollment trends.  According to a ... Planning and Evaluation, Department of Health and Human ... enrolled in individual medical plans through the Marketplace ...
Breaking Medicine Technology:TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2Insights into the Marketplace and Individual Market Growth 2
... 30, 2011  HCB Health, one of the nation,s top ... Edgemont Pharmaceuticals for the national launch of the company,s ... mg generic version of Prozac®   marketed in ... prescribed products for treating major depression, with more than ...
... its Imaging 2.0 commitment to provide global access to ... AEX: PHI) today showcased several new additions to its ... right solution at the right price point catering to ... meeting of the Radiological Society of North America (RSNA), ...
Cached Medicine Technology:HCB Health Wins Fluoxetine Launch Assignment From Edgemont Pharmaceuticals 2Philips Answers the Call for Worldwide Access to Advanced Imaging Systems for Diagnosis and Treatment 2Philips Answers the Call for Worldwide Access to Advanced Imaging Systems for Diagnosis and Treatment 3Philips Answers the Call for Worldwide Access to Advanced Imaging Systems for Diagnosis and Treatment 4Philips Answers the Call for Worldwide Access to Advanced Imaging Systems for Diagnosis and Treatment 5
The Vitatron Excellence S+ lead series are endocardial leads providing excellent reliability and optimal pacing characteristics....
The family of Passive Plus DX passive-fixation leads features a 5 mm tip, designed to increase current density and pacing impedance, and a tine fixation, offering versatility and security in lead pla...
... The IsoFlex S lead's small ... ease implantation and lower the ... smaller, more tortuous vessels. Atrial ... and fixation options combine to ...
Unipolar Atrial "J" Lead...
Medicine Products: