Navigation Links
New Generation Clinical Trials Could Save Time And Money, Improve Patient Care

In this era of personalized medicine, one should reevaluate new medicines and treatments for cancer, says Prof. Donald Berry//, Ph.D.,

Dr. Berry, professor and chair of the Department of Biostatistics and Applied Mathematics at The University of Texas M. D. Anderson Cancer Center, sees a need to rethink how clinical trials are designed and conducted in the U.S. He thinks the current 50-year-old system, will not be able to cope with the strain of 21st century medicine, and something should be done to relieve that strain.

Berry outlines his new approach to clinical trials in the January 2006 issue of Nature Reviews Drug Discovery. In the article, he advocates that the statistical method used to evaluate new drugs be turned on its head. He says the statistical method used nearly exclusively to design and monitor clinical trials today—a method called frequentist or Neyman-Pearson (for the statisticians who advocated its use)—is so narrowly focused and rigorous in its requirements that it limits innovation and learning.

The solution, which he has advocated for over 30 years, is to adopt a system called the Bayesian method, a statistical approach he says is more in line with how science works. He sites examples of Bayesian approaches being used routinely in physics, geology and other sciences. And he is putting his approach to the test at M. D. Anderson, where over 100 cancer-related phase I and II clinical trials are being planned or carried out using the Bayesian approach.

The main difference between the Bayesian approach and the frequentist approach to clinical trials is how each method deals with uncertainty, an inescapable component of any clinical trial. Unlike frequentist methods, Bayesian methods assign anything unknown a probability using information from previous experiments, explains Berry. In other words, Bayesian methods make use of the results of previous experiments, whereas frequentist approaches assume we have no prior results.

Using the Bayesian approach, it is possible to do continuous updating as information accrues. This characteristic makes it possible for medicine to build adaptive designs in clinical trials.

Berry argues that the Bayesian approach is better for doctors, patients who participate in clinical trials and for patients who are waiting for new treatments to become available.

Doctors want to be able to design trials to look at multiple potential treatment combinations and use biomarkers to determine who is responding to which medication. At the end of the day, when they enroll the last patient in the study, they want to be able to treat that patient optimally depending on the patient's disease characteristics. In the Bayesian approach, the trial design exploits the results as the trial is ongoing and adapts itself based on these interim results. This kind of approach is anathema in the standard approach.

However, Berry argues, such flexibility is crucial to clinical trials in the 21st century
'"/>




Related medicine news :

1. Hearing Problems Of Middle Age Are Affecting The Younger Generation
2. Tigecycline – New Generation Tetracycline With Broad Spectrum Antibacterial Activit
3. Newer Generation Sleeping Pills Lack Superior Performance
4. Moles Among The Older Generation May Be Dangerous
5. Leptin, The Next Generation Antidepressant?
6. Generation Scotland To Examine Relation Between Lifestyle, Genetics and Health
7. Baby Gloom: ‘Baby Gap’ Generation Signals Babies’ Days Ot!
8. Researchers Aim To Develop Next Generation Of Surgical Robots
9. New Generation Teenagers Addiction to Prescription Drugs
10. New Generation - Medicinal Products
11. Take Third Generation Oral Contraceptives Off the Shelves-consumer Group Insists
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/4/2016)... ... May 04, 2016 , ... ... support for knees, ankles, and elbows. Engineered with athletes in mind, OMNIFORCE ... manufacturing (opposed to ineffective circular knitting, common in the industry) produces premium ...
(Date:5/4/2016)... ... May 04, 2016 , ... With the stamp of approval from the ... May as National Cancer Research Month. According to the American Cancer Society (2016) ... predications of one in four Americans dying as a result. , With numbers as ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... Group is scheduled on July 25-27, 2016 at Las Vegas. It aims to ... professionals from educational institutes and research organizations across the globe; making the conference ...
(Date:5/3/2016)... ... May 04, 2016 , ... An accurate ... reaching the global health community through expanding activities that embrace training, standards, technology ... the resource-limited countries. , In support of this important work, ASCP ...
(Date:5/3/2016)... ... 03, 2016 , ... In April, Amerec launched a new website designed with ... the best steam and sauna solutions. , First, the Amerec website has been redesigned ... all of the site’s features, especially the Steam Builder Tool , to both ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... DUBLIN , May 3, 2016 ... to pay $55 million to a woman who says ... State court awarded Gloria Ristesund $5 million ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... of accusations against the company. In February, the same ...
(Date:5/3/2016)... 2016 Global and Chinese ... basic overview of the industry that covers definition, ... mesh report explores into the international and Chinese ... on Surgical Mesh market spread across 150 pages ... figures is available at http://www.reportsnreports.com/reports/470569-global-and-chinese-surgical-mesh-industry-2016-market-research-report.html . ...
(Date:5/2/2016)... 2016  While nearly three-quarters of Americans (71%) are ... their health, only about half report taking any steps ... of a new survey announced today by Hologic (Nasdaq: ... National Osteoporosis Month, Hologic is raising awareness of this ... million Americans. Osteoporosis is a disease that ...
Breaking Medicine Technology: