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New Gene Therapy Treats Diabetic Neuropathy

A preclinical trail carried out to treat diabetic nerve damage has shown promising results. A novel therapeutic, discovered by researchers// of the University of Manchester, when injected into the system, it was found to trigger a particular gene responsible to prevent nerve damage in hands and feet – diabetic neuropathy.

The positive preclinical results – reported in the journal Diabetes – are further evidence that the research could lead to a new treatment for diabetic nerve damage or 'neuropathy'; initial-stage clinical trials on patients in the United States have also been encouraging.

Lead researcher Professor David Tomlinson says the study has massive potential for managing the condition and preventing thousands of foot amputations each year.

‘The vast majority of non-traumatic hand and foot amputations carried out in UK hospitals are caused by diabetes and there are currently no treatments available to prevent or slow the progress of nerve disease in diabetic patients,’ he said.

‘Our tests have shown that a single injection of a DNA-binding protein protected nerve function, stimulated nerve growth and prevented tissue damage that in humans can lead to limb loss.’

An estimated 50 per cent of patients with long-term diabetes develop some form of neuropathy that can cause numbness and sometimes pain and weakness in the hands, arms, feet and legs. Progression to amputation is not inevitable, but it is always a threat.

Problems may also occur in other organs, including the heart, kidneys, sex organs, eyes and digestive tract.

‘Diabetic neuropathy is a major problem in insulin-dependent diabetes, particularly in patients who have had the disease for a period of time,’ said Professor Tomlinson, who is based in the University's Faculty of Life Sciences.

‘Our approach to gene therapy is quite different to previous attempts at treatment: we use a DNA-binding protein called ZFP TFTM
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