Navigation Links
New Findings in Fragile X Mental Retardation Protein

Researchers in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine have done crucial progress in understanding Fragile X mental retardation protein (FMRP), laying the groundwork for possible new treatments for Fragile X syndrome(FXS).

Fragile X syndrome, the leading inherited form of mental retardation is mainly caused by a mutation in the FMR1 gene on the X chromosome, leading to the loss of FMRP, which is abundantly expressed in the brain and testes. Without this protein, brain development is hampered and nerve cells cannot communicate with each other appropriately, resulting in the reduced ability to learn and memorize.

Fragile X syndrome affects about one in 4,000 males and one in 8,000 females. About 20 percent of children with FXS have autism and about five percent of autistic children have FXS. The research team led by Yingqun Huang, M.D., assistant professor in Yale Ob/Gyn, previously found that FMRP interacts with a nuclear mRNA export protein NXF2, in the mouse brain and testes. In this study, the team used mouse neuronal cells to explore the functional characteristics of this interaction.

We found that FMRP, together with NXF2, acts to down-regulate the expression of its target, the messenger RNA that encodes NXF1, which is an essential protein needed to transport most mRNAs from the nucleus to the cytoplasm of cells, said Huang. Our findings explain why the NXF1 protein level is much lower in the hippocampal neurons involved in learning and memory than in many other cells. This may suggest that a high level of NXF1 might hinder the function of these cells.

We are one of the first two labs to show that FMRP regulates gene expression at the mRNA stability level, Huang added. The idea is to find the mechanisms underlying the function of FMRP so in the future, we can develop more effective interventions.

Huang said future studies will look more clo sely at how FMRP works with NXF2 to regulate its targets. She said, We expect to identify more targets which are regulated by FMRP and NXF2. This will be a new direction in the FMRP research field.


'"/>




Related medicine news :

1. Latest Findings On The Deadly Disease - SARS
2. New Findings Could Reduce The Extent Of Spinal Cord Injuries
3. New Findings for Repeated Miscarriages
4. How Healthy Are Herbal Products? US Findings.
5. Dispute in Findings about Radiation exposure
6. New Findings on Autism Research
7. Engineering Nutrient-Rich Plants Made For Feasible By New Findings
8. Study Findings Could Help In Developing A Better Drug Delivery System
9. Findings Suggest New Method to Fight Staph Infections
10. Most Suicide Rates Decline, but Findings Are Puzzling
11. Arimidex-Herceptin Combo Therapy For Breast Cancer-Clinical Trial Findings
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... ... ... “The Land of More and More”: a brilliant story for children and ... simple and achievable answer. “The Land of More and More” is the creation of ... Angola, Indiana where he works with the children’s ministry department. , Michael says ...
(Date:1/19/2017)... ... 19, 2017 , ... Aerolib Healthcare Solutions ... Clinical and Regulatory education for Physicians, Physician Advisors, Case managers, Utilization Review ... of Disease Specific Documentation Improvement. , The Aerolib Learning Management System is ...
(Date:1/19/2017)... ... , ... With the cold weather here, many people will have to clear snow with snow ... amounts of snow, but they can be dangerous when used incorrectly. That’s why Amica ... the proper use of snow blowers:, , When removing wet snow ...
(Date:1/19/2017)... ... 2017 , ... WhoHaha , a digital media company dedicated to creating ... to produce a three-part video series that uses humor to highlight ways to improve ... of AHA’s Healthy For Good™ movement, which is designed to inspire all Americans to ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... medical capacity this year. Drs. Alexander Paziotopoulos, Andrew Petersen and Trish Henrie-Barrus will ... version of the clinic’s leading recovery program. , “We know it’s easy ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... , Jan. 20, 2017  Palladian Health, a ... announced the launch of an opioid management program ... on opioids and helps stem the growing tide ... prescribed to treat chronic non-cancer pain (back pain, ... risks and lack of evidence regarding long-term effectiveness. ...
(Date:1/20/2017)... -- Avillion LLP, a co-developer and financier of late-stage ... MD MBA as Chief Medical Officer. Dr Weinberg will be based ... ... spent more than 17 years as a pharmaceutical and biotech executive ... Over the course of his career, he has interfaced with the ...
(Date:1/19/2017)... Report Details What can be ... going to grow at the fastest rates? This visiongain ... trends, opportunities and prospects. Our 190-page report provides ... areas in the industry and the future market prospects. ... the all the major categories of the ophthalmic devices ...
Breaking Medicine Technology: