Navigation Links
New Findings in Fragile X Mental Retardation Protein

Researchers in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine have done crucial progress in understanding Fragile X mental retardation protein (FMRP), laying the groundwork for possible new treatments for Fragile X syndrome(FXS).

Fragile X syndrome, the leading inherited form of mental retardation is mainly caused by a mutation in the FMR1 gene on the X chromosome, leading to the loss of FMRP, which is abundantly expressed in the brain and testes. Without this protein, brain development is hampered and nerve cells cannot communicate with each other appropriately, resulting in the reduced ability to learn and memorize.

Fragile X syndrome affects about one in 4,000 males and one in 8,000 females. About 20 percent of children with FXS have autism and about five percent of autistic children have FXS. The research team led by Yingqun Huang, M.D., assistant professor in Yale Ob/Gyn, previously found that FMRP interacts with a nuclear mRNA export protein NXF2, in the mouse brain and testes. In this study, the team used mouse neuronal cells to explore the functional characteristics of this interaction.

We found that FMRP, together with NXF2, acts to down-regulate the expression of its target, the messenger RNA that encodes NXF1, which is an essential protein needed to transport most mRNAs from the nucleus to the cytoplasm of cells, said Huang. Our findings explain why the NXF1 protein level is much lower in the hippocampal neurons involved in learning and memory than in many other cells. This may suggest that a high level of NXF1 might hinder the function of these cells.

We are one of the first two labs to show that FMRP regulates gene expression at the mRNA stability level, Huang added. The idea is to find the mechanisms underlying the function of FMRP so in the future, we can develop more effective interventions.

Huang said future studies will look more clo sely at how FMRP works with NXF2 to regulate its targets. She said, We expect to identify more targets which are regulated by FMRP and NXF2. This will be a new direction in the FMRP research field.


'"/>




Related medicine news :

1. Latest Findings On The Deadly Disease - SARS
2. New Findings Could Reduce The Extent Of Spinal Cord Injuries
3. New Findings for Repeated Miscarriages
4. How Healthy Are Herbal Products? US Findings.
5. Dispute in Findings about Radiation exposure
6. New Findings on Autism Research
7. Engineering Nutrient-Rich Plants Made For Feasible By New Findings
8. Study Findings Could Help In Developing A Better Drug Delivery System
9. Findings Suggest New Method to Fight Staph Infections
10. Most Suicide Rates Decline, but Findings Are Puzzling
11. Arimidex-Herceptin Combo Therapy For Breast Cancer-Clinical Trial Findings
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/30/2016)... ... November 30, 2016 , ... Standard ... 75, an annual ranking and recognition of the largest closely held companies headquartered ... ranked from 2008-2016. In addition, Standard Process was awarded the Talent Award for ...
(Date:11/30/2016)... ... November 30, 2016 , ... Center For ... announced the opening of a new residential mental health treatment program in Chino ... issues such as severe anxiety, depression, bi-polar disorder, and other related issues. , ...
(Date:11/30/2016)... ... 30, 2016 , ... The Cronovo Smartwatch, the first on ... consumers at an affordable price, is now available on the crowdfunding website ... game changer” when it comes to the smartwatch. , "With Cronovo, we’ve combined ...
(Date:11/30/2016)... ... 2016 , ... The Valley’s leading orthopedic practice, OrthoArizona - ... North Phoenix and Chandler locations. , The new North Phoenix location is located ... 3rd St, Suite 300 in Phoenix. The practice’s new Chandler location is conveniently ...
(Date:11/30/2016)... ... November 30, 2016 , ... BrightStar Care of Wellington , a ... was recently named the 2016 Provider and Employer of Choice by Home Care Pulse. ... scores, and only providers with the highest quality receive the Best of Home Care ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016 According to a ... by Product (Instruments, Reagents, Software), Technology (Immunoassay, Clinical ... Nephrology, Infectious Diseases) - Forecast to 2021" published ... USD 60.22 Billion in 2016. This market is ... during the forecast period (2016-2021) to reach USD ...
(Date:12/2/2016)... In the first ever attempt to include ... from C. sativa, the Hebrew University in Jerusalem, the ... II , the Universita` del Piemonte Orientale and Phytoplant ... and unified inventory of phytocannabinoids of different botanical origin. ... remarkable chemical and structural diversity of phytocannabinoids. As a ...
(Date:12/2/2016)... , Dec. 2, 2016  Eli Lilly and ... financial guidance for 2017 and provide updated financial guidance ... also conduct a conference call on that day with ... company,s financial guidance. The conference call will ... general public can access a live webcast of the ...
Breaking Medicine Technology: