Navigation Links
New Evidence Links Smallpox Vaccination Side Effects to Genetic Factors

Boffins have found new evidence that supports the link between genetic factors and certain adverse reactions related to smallpox vaccination .

Immunization with live virus particles, as in the smallpox vaccine, is sometimes found to cause reactions that range from fatigue to serious illness.

The study was conducted by a team of researchers led by Samuel L. Stanley Jr. at the Washington University, St. Louis University, and The Emmes Corporation.

As part of the study, researchers examined 346 individuals who had participated in previous smallpox vaccination trials, 94 of whom developed fevers after vaccination to test whether people who develop fever after vaccination have genetically determined differences in their immune responses compared to those who do not.

The study found that some individuals who were given stored smallpox vaccine, which uses live vaccinia virus, developed fevers.

Researchers identified a total of eight haplotypes in four different genes that were associated with altered susceptibility to fever after vaccination.

It is the first study to show that fever after smallpox vaccination is associated with specific gene clusters in the interleukin-1 (IL-1) gene complex on chromosome 2 and the interleukin-18 gene on chromosome 11.

The interleukins, and especially the IL-1 gene complex, are groups of molecules associated with inflammation and immune responses. The IL-1 gene complex, and especially the IL-1A gene, was the site most significantly associated with different risks of fever.

Vaccines are the safest and most effective way to prevent a number of very important childhood and adult diseases. Our work is designed to identify ways we might make vaccines even more acceptable in the future by discovering ways to further reduce the chance of minor adverse, Stanley said.

According to James E. Crowe Jr of Vanderbilt University Me dical Center the findings represent an important preliminary step in understanding the variations in host responses to vaccines, and further studies will be needed to replicate these findings, and to test other vaccines.

The long-term goal is to determine genetic features that could be determined prior to vaccination, allowing practitioners to modulate the vaccination plan according to risk. This type of practice, the goal of personalized predictive medicine, appears closer in feasibility than ever given the pace of genetic testing, Crowe said.

The findings of the study were published in the July issue of The Journal of Infectious Diseases.


'"/>




Related medicine news :

1. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
2. Evidence supporting H.pylori eradication
3. Evidence against use of Beta blockers as first choice in the treatment of primary hypertension
4. Evidences that Better Health Care Facility is Offered By Public Hospitals.
5. First Conclusive Evidence Linking Oral Bacteria To Premature Babies
6. Study Provides Evidence That Obesity Leads To A More Aggressive Ovarian Cancer
7. No Clear Evidence for Ultra-Low Cholesterol Targets?
8. Lack of Evidence on Treatment for Narrowed Kidney Arteries
9. Some Evidence Shows Chinese Herbal Medicine Helps Angina Patients
10. Strong Evidence Suggests Incidence Of Mating Of Ancestors With Neanderthals
11. Dermatologists Provide Unique Evidence of Possible Cause of Rare Skin Condition
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... ... December 08, 2016 , ... Catalent Pharma Solutions, ... biologics and consumer health products, today announced that it had joined the Pharmaceutical ... a non-profit organization to unite pharmaceutical and healthcare companies that share a vision ...
(Date:12/8/2016)... ... ... STAT courier is pleased to announce that due to customer demand, as well ... presence in Dallas. One of the most exciting parts for STAT is that the ... and Forth Worth market. STAT takes pride in treating their employees with integrity and ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... as possible. With this in mind, SIGVARIS has created a new line of ... during bed rest and provide the benefits of graduated compression when transitioning from ...
(Date:12/8/2016)... ... December 08, 2016 , ... Vida Health, the digital ... B led by Canvas Ventures . Other investors include Nokia Growth Partners (NGP) ... platform to serve more consumers who are managing chronic conditions or simply ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Dianne ... offices headquartered in Hamilton County, is embarking on a charity drive with the ... finding new homes for orphaned or neglected senior dogs in the Cincinnati region, ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 2016  Eli Lilly and Company (NYSE: ... 3 EXPEDITION3 trial at the 9 th Clinical ... solanezumab did not meet the primary endpoint in the ... people with mild dementia due to Alzheimer,s disease (AD), ... for the treatment of mild dementia due to AD. ...
(Date:12/8/2016)... -- Research and Markets has announced the addition of ... Type, Application, Usability - Forecast to 2025" report to their ... , , ... to grow at a CAGR of around 3.2% from 2015 to ... include advancements in extracellular microelectrode arrays and intracellular microelectrodes, research in ...
(Date:12/8/2016)... CAMBRIDGE, Mass. , Dec. 8, 2016 /PRNewswire/ ... today that Nationwide Children,s Hospital signed ... enhance and accelerate the development of new cures. ... healthcare organizations representing over 57 million patients globally, ... are working together to improve protocol design, site ...
Breaking Medicine Technology: