Navigation Links
New Engineered Drug Shows Promise in Treating Lymphocytic Leukaemia

A recent research has found that a new type of engineered drug may have the potential to treat chronic lymphocytic leukaemia.

The study by researchers at the Ohio State University Comprehensive Cancer Center was published online in the journal Blood.

The research has established that an engineered drug candidate is promising in treating lymphocytic leukemia in both test tube and early animal tests.

The agent represents a new class of agents called small modular immunopharmaceuticals. This agent, which is called CD37-SMIP, targets a protein called CD37 on the surface of these leukemia cells.

The study shows that the agent can successfully attach to the protein on the leukemia cells and destroy them. It works both by activating the cells' self-destruction and by causing a particular class of immune cells to attack them.

In an animal model, the agent worked uniformly over and above the drug rituximab, now routinely used to treat chronic lymphocytic leukemia (CLL) patients. Rituximab targets a different protein on leukemia cells.

"Our findings have significant implications for the treatment of CLL and related malignancies," says principal investigator John C. Byrd, director of the hematologic malignancies program at Ohio State 's James Cancer Hospital and Solove Research Institute.

Overall, Byrd says, "the findings point out that this could be an effective agent for treating CLL and other malignancies, such as non-Hodgkin's lymphoma and acute lymphoblastic leukemia when they have expression of the CD37 protein."

The laboratory portion of the study used CLL cells from patients, laboratory-grown non-Hodgkin's lymphoma cells and acute lymphocytic leukemia cells.

This research showed that the agent kills leukemia cells directly by triggering their self-destruction through the process of apoptosis.

The study also found that thi s self-destruction happens differently from how other drugs cause apoptosis. Most drugs cause cells to self-destruct by triggering a cell mechanism that requires enzymes called caspases. This new agent, however, works through a mechanism that does not call for caspases.

"This is exciting because it means that this agent may benefit patients who are resistant to other CLL drugs," says co-author Natarajan Muthusamy, a research scientist with Ohio State's Comprehensive Cancer Center. "It also suggests that it might work well in combination with other drugs, as well as alone."

The findings also show that after the agent joins with the cancer cells, it attracts immune cells called natural killer cells, which also devastate the leukemia cells.


'"/>




Related medicine news :

1. Regulators Object Drug Produced from Genetically Engineered Farm Animals
2. Engineered Tissue Implants benefited Knee Injured patients
3. Indian American have Genetically Engineered Edible Cottonseed
4. USDA Gives Go-Ahead to Market Controversial Genetically Engineered Rice, LL601
5. Xylitol To Be Produced By Genetically Engineered E. Coli
6. Genetic-Engineered Cows Resist Mad Cow Disease
7. Researchers Explore the Effect of Engineered Immune Cells on HIV
8. Tissue Engineered Scaffolding Allows Reproduction of Cartilage Tissue
9. Experimental treatment for Ebola Virus Shows promising results in mice
10. New Prostate Cancer Vaccine Shows Promise
11. Ebola Treatment Shows Promise
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... , ... June 24, 2016 , ... June 19, 2016 ... dangers associated with chronic pain and the benefits of holistic treatments, Serenity Recovery ... are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
(Date:6/24/2016)... ... ... Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair ... hour by 2020 and then adjusting it yearly to increase at the same rate as ... the wage floor does not erode again, and make future increases more predictable. , The ...
(Date:6/24/2016)... York, NY (PRWEB) , ... June 24, 2016 ... ... publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as a ... that “the most beautiful women in the world, and the most handsome men, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
Breaking Medicine Technology: