( n MK-0518 because it works in a differe...)New Drug Offers Promise as Single Treatment for HIV,Health

n MK-0518 because it works in a different way than other anti-HIV drugs. Previous antiretroviral drugs target enzymes called reverse transcriptase and protease, which play key roles in the virus' ability to reproduce itself.

MK-0518 targets a "third enzyme" called integrase, which is found only in HIV and is essential to the virus' ability to insert its DNA into human genes. By blocking integrase, MK-0518 blocks HIV's ability to reproduce itself and infect new cells. Because it works differently, MK-0518 should also reduce interactions with other anti-HIV drugs.

Although preliminary, the study suggests that MK-0518 is a potent, well-tolerated single-drug treatment that is highly effective in reducing HIV viral loads, the investigators conclude. Based on the successful results, a second phase of the study—comparing various doses of MK-0518 with current combinations of anti-HIV drugs—is already underway.

Source-Newswise
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