Navigation Links
New Drug Effective for Low Blood Pressure

Patients with a condition called orthostatic hypotension have problems with sinking blood pressure when standing up from a sitting position.// Current treatments help increase blood pressure when standing but also cause blood pressure to soar when lying down, increasing the risk for stroke. Researchers say that a new drug application could help patients with low blood pressure.

Blood pressure control lessens with age, making orthostatic hypotension especially common in those over age 70. Common causes of the condition include diabetes, autonomic neuropathy, multiple system atrophy, pure autonomic failure, and Parkinson's disease. Drugs used to control blood pressure are often catalysts for orthostatic hypotension.

A recent study reveals that the drug pyridostigmine, also known as Mestinon or Mestinon Timespan, could be the answer. Pyridostigmine has been used for years to treat myasthenia gravis, a neuromuscular disease. The drug works at the level of the autonomic ganglion, which has minimal nerve signaling traffic when lying down. When standing up, however, nerve signaling traffic in the autonomic ganglion increases. Researchers theorized a drug that affects the autonomic ganglion would improve nerve transmission for orthostatic hypotension patients and trigger the reflex that controls blood pressure in all positions.

Researchers studied 58 patients. Patients either received a placebo, pyridostigmine alone, or pyridostigmine in combination with one of two low dosages of midodrine (ProAmatine), a drug known to improve orthostatic hypotension. Researchers measured the effects of the drugs one hour post-treatment. Pyridostigmine significantly improved the patients' standing blood pressure without raising blood pressure lying down. The positive effects of the drug were further improved when combined with low-dose midodrine. Side effects were mild, including some abdominal cramping or the need to use the bathroom more than usual. A follow-up occurred two years after the trial. Information was available on 32 of the patients, and 75 percent reported either good or excellent results from the pyridostigmine treatment. About 25 percent used pyridostigmine alone, and about 33 percent needed a lower dose of another medication. Researchers conclude saying that in the future more study needs to be done in this area .

Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Inhaled Steroids Safe & Effective for Children with Asthma
3. ZD1839 Proves Effective - A Breakthrough in fighting Lung Cancer
4. Fluoride Found Effective in Osteoporosis
5. Aspirin and Warfarin Are Equally Effective for Stroke Prevention
6. Implantable Contact Lens Found Safe and Effective
7. Effective And Economical Agent For Anthrax
8. Stem Cell Transplants May Be Effective For MS Patients
9. Effective therapy for Huntingtons disease
10. Chemotherapy Effective for Bladder Cancer
11. Drug Effective for Vascular Dementia
Post Your Comments:

(Date:6/27/2016)... ... , ... "FCPX editors can now reveal their media with growing colorful split ... Austin - CEO of Pixel Film Studios. , ProSlice Color brings the split ... now reveal the media of their split screens with growing colorful panels. , ProSlice ...
(Date:6/26/2016)... ... , ... Quality metrics are proliferating in cancer care, and are derived from ... of the beholder, according to experts who offered insights and commentary in the current ... For the full issue, click here . , For the American Society of ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are confused ... endometriosis. These women need a treatment plan to not only alleviate symptoms and ... help for preservation of fertility and ultimately achieving a pregnancy. The specialists at ...
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 , , , WHEN: ... 2016 , , , , LOCATION: , , , Online, ... , , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global ... Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager ... pharmaceutical industry is witnessing an exceptional era. Several new demand spaces, ...
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today ... Inc.,s Supplier Horizon Award . One ... Guerbet was recognized for its support of Premier members ... through clinical excellence, and commitment to lower costs. ... receive this recognition of our outstanding customer service from ...
(Date:6/23/2016)... The Biotechnology industry might still ... great opportunities to investors. assesses the recent performances ... XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ARNA ), and Regeneron Pharmaceuticals Inc. (NASDAQ: ... your complimentary trade alerts at: ...
Breaking Medicine Technology: