Navigation Links
New Drug ALT-711 decreases blood vessel stiffness

A novel drug that breaks down collagen bonds in the body's blood vessels significantly decreases the stiffness of vessels in older people, according to a study conducted by National Institute on Aging (NIA) scientists and others. The finding suggests the medication could be a new treatment for high blood pressure, heart failure, and certain complications of diabetes. The drug, ALT-711, snips bonds or crosslinks created in the arteries and other tissues when glucose attaches to the protein collagen. //

Crosslinks are cable-like structures that inhibit the natural flexibility of collagen strands. They tend to proliferate with age. Crosslinks appear to toughen tissues and may contribute to some of the deterioration associated with aging and diabetes, such as elevated systolic blood pressure, stiff arteries, and impaired kidney function.

The ability to reduce vascular stiffness could have a major influence on reducing deaths from heart disease. For the current study, investigators at nine U.S. clinical centers recruited 93 people over the age of 50 who showed evidence of vascular stiffening, including high systolic blood pressure and pulse pressure of at least 60 mm Hg.

The participants were randomly divided into two groups-those who received daily doses of ALT-711 and those who were given a placebo daily. After 56 days, arterial pulse pressure - the difference between systolic and diastolic blood pressures - was significantly reduced among those taking the drug compared to the placebo group.


'"/>




Page: 1

Related medicine news :

1. Headache decreases appetite
2. Contraceptives decreases Libido
3. Alcohol decreases risk of dementia
4. Cooling decreases heart attack effects
5. Vitamin E decreases high blood pressure in kidney failure
6. Light therapy decreases depression during pregnancy
7. Perceived stress decreases vaccine response
8. Infant receives first bloodless liver transplant
9. Spouses and other partners lower blood pressure says new research
10. H2O - a cure for low blood pressure
11. Uncontrolled blood pressure
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/5/2016)... Tucson, AZ (PRWEB) , ... May 05, 2016 , ... ... more attention being paid to the impact our aging population has on communities and ... help aging adults plan for and face age-related challenges. , Aging Life Care ...
(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... ... “deeming regulations” for electronic cigarettes, requiring e-cigarette manufacturers to submit their products ... “tobacco product,” apply to all vaping products that entered the market since February ...
(Date:5/5/2016)... ... 05, 2016 , ... This weekend, from Friday, May 6 - Sunday, May 8, fifteen elite ... the first Team Semper Fi Mountain Bike Camp, hosted in conjunction with WTB ... Mark Weir and Jason Moeschler, who’ll share pro tips with the injured veterans as they ...
(Date:5/5/2016)... ... ... LELO has discovered many people are insecure about their techniques in ... media and on the Volonté blog seeking advice about how to actually masturbate and ... , While some methods are more common than others, there is no one ‘right ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... laws in all U.S. states and certain Canadian provinces is now available from ... Compensation Research Institute (WCRI). , The report, Workers’ Compensation Laws as ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... -- Research and Markets has announced the addition ... USA"  report to their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Positron Emission Tomography (PET) scanner and cyclotron install base ... with the current known number of PET scanners and ... report also contains a detailed breakdown of this equipment ...
(Date:5/5/2016)... , May 5, 2016 ... addition of the  "Europe Thalassaemia Market and ... their offering.       (Logo: ... Europe Thalassaemia Market and Competitive Landscape Highlights ... pipeline products, Thalassaemia epidemiology, Thalassaemia market valuations ...
(Date:5/4/2016)... upgrade. There are many medical recorders on the market but none like this. Through ...  offers unparalleled connectivity and functionality.  Ampronix  is a renowned authorized reseller of the medical ... Photo - http://photos.prnewswire.com/prnh/20160503/363416 ... ... ...
Breaking Medicine Technology: