( Developments in rheumatoid arthritis re...)New Developments in Rheumatoid Arthritis,Health

Developments in rheumatoid arthritis reported at Federation of Clinical Immunology Services meeting in San Diego to figure out what makes these people susceptible to the disabling inflammatory condition.

Dr. Gregersen has finally closed the circle between key genes identified in his laboratory at the Robert S. Boas Center for Genomics and Human Genetics at The Feinstein Institute for Medical Research in Manhasset, NY and more than a 1,000 patients with rheumatoid arthritis. The genes will help tell the story of how the immune system works to create specific antibodies that in turn increase a persons risk for this crippling disease.

On Monday at the Federation of Clinical Immunology Services (FOCIS) meetings in San Diego, CA, Dr. Gregersen and his colleagues will be presenting the labs latest genetic findings. The group conducted genome-wide scans to identify polymorphisms, or genetic variants, that are associated with the inflammatory condition and can be used to understand the triggers of the disease.

This will provide key insights into the pathways underlying rheumatoid arthritis and other autoimmune diseases. It may ultimately provide tests to predict who will respond to the available new treatments. Franak Batliwalla, PhD, also of The Feinstein Institute, will be presenting related studies on biomarkers and genetic influences on drug response at the same meeting.

Identifying Immune System Mediators About one percent of the US population will develop rheumatoid arthritis, an autoimmune disease that leads to painful joint swelling. Scientists are cracking the genetic code that makes the immune system wage an attack on a persons joints. Over the last decade, Dr. Gregersen and his colleagues have been amassing a genetic database complete with siblings with rheumatoid arthritis (and some family members without it) in an attempt to single out those genes that are involved in the autoimmune process.

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