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New Cost-cutting Cancer Drug Delivery System

plied for use with a range of compounds treating a variety of diseases, but thus far the company has focused primarily on cancer treatments, collaborating with the Moores Cancer Centre of the University of California, San Diego.

”Cancer drug delivery is no longer simply wrapping up cancer drugs in a new formulation for different routes of delivery,” says NDT.

”Cancer chemotherapy, in particular for recurrent and metastasis disease, has had limited therapeutic effect due mostly to the inherently toxic nature of conventional anticancer drugs, with the most common side effect caused by dose-dependent toxicity. It has been reported that more than 40 per cent of anticancer drugs being developed show aqueous solubility problems, which severely affects the cancer drug performance.”

NDT says that its polymer synthesis expertise have enabled the company to develop a system that can overcome these difficulties. The firm has created a biodegradable, hydrophilic material that can be used with traditional therapeutic agents and thus greatly improve solubility of the drug.

In addition to this, the firm points out that most compounds used as therapeutic agents are comprised of very small particles whereas combining them with the polymeric carrier increases the particle size to 100nm. According to NDT, this will allow the treatment to remain in the bloodstream for a longer period of time thus increasing therapeutic efficacy, and will also reduce side effects by preventing migration of the drug to normal tissues.

The research team at the company carried out animal tests to establish the efficacy of the polymeric carrier, using a chemotherapy drug in a single cancer model. The findings from the trials were very promising, with the carrier-based drug delivery resulting in nine times more drug found in plasma and 17 times more in tumour tissue when compared to free drug delivery.

In light of the potential app
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