Navigation Links
New Chemistry Approach Promises Less Expensive Drugs

supported the work. "What's particularly exciting to me is the depth and rigor of the analysis that enabled this very creative breakthrough. Equally important, MacMillan has discovered new reactions that will streamline the synthesis of compounds that are relevant to human health."

Most drug molecules that pharmaceutical companies produce can exist in two different forms, which are mirror images of one another. Though both forms of an organic molecule -- known in the chemistry world as "enantiomers" -- have the same chemical formula, their effect on the body can differ dramatically.

"The two enantiomers are like keys with the same number of teeth, but which have different orientation," MacMillan said. "One key fits in with our biology very well, opening the correct doors in our body and helping us to heal. But the other key doesn't fit the same doors because its teeth are in opposing locations."

The two forms are indistinguishable by most modern lab tests, yet our bodies can tell the difference. Where one enantiomer might be the basis for a helpful drug, its mirror image might do nothing for the body, or even damage it.

"This was the problem in the 1960s with the drug phthalidomide," MacMillan said. "One of its enantiomers helped pregnant women overcome morning sickness. Its mirror image, however, caused birth defects."

In the vast majority of cases, the Food and Drug Administration now requires that drug companies create only the beneficial enantiomer during the manufacturing process. While this requirement keeps any of these helpful molecules' "evil twins" from reaching our systems, it also places heavy demands on the drug companies.

Building large quantities of a drug molecule often requires a catalyst, a substance that permits a chemical reaction to take place without itself being affected. Until recently, however most catalysts would create both enantiomers simultaneously, MacMillan said. I
'"/>




Page: 1 2 3 4

Related medicine news :

1. Love And Drug Addiction Share The Same Chemistry
2. The Chemistry Of Sexual Attraction Between Male And Female Elephants
3. Chemistry Over The Counter: Is It Just What The Doctor Ordered?
4. New Dietary Approach To Manage Kidney Stones
5. Approaching through Telemedicine benefits patients
6. Gel Offers A More Targeted Approach
7. New Cost Effective Approach To Promote Sun Protection
8. Treatment Of Brain Aneurysms By A New Non-Surgical Approach
9. A New Approach In Treatment Neurogenic Detrusor Overactivity In Children
10. A New Diagnostic Approach To Pediatric Interstitial Lung Disease
11. Lazy Eye Can Be Effectively Treated By New Approach
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Chemistry Approach Promises Less Expensive Drugs

(Date:4/25/2015)... (PRWEB) April 25, 2015 The impact ... still eliciting the excitement of the public and is ... the months of May and June. From March ... their biannual tradition of "Special Prayers." More than 600 ... attended previous Special Prayers and have reported intense experiences ...
(Date:4/25/2015)... 25, 2015 Parker and Sons projects growth ... has spiked in Arizona alongside the growing economy. As a ... employees for April to help account for the rising need ... in April is something we are enthusiastic about. It means ... Kelly, president at Parker and Sons. , Indeed, Parker and ...
(Date:4/25/2015)... 2015 On Friday, April 17, Interstate ... annual Best Implementation Award. This award is given ... use of RFID technology to improve its manufacturing, supply ... that best demonstrates how RFID is delivering real value ... Journal Live! 2015 in San Diego, the RFID industries ...
(Date:4/24/2015)... April 24, 2015 Constellations Recovery celebrates ... in Westchester County. Just 35 miles from New York ... back into everyday life while recovering from addiction. The ... 2015, will allow therapists, doctors and treatment centers to ... more about the opportunities offered by Constellations Recovery.,  , ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 Ryadon is ... wide range of capabilities and services to complement any ... Ryadon's Quantity Discount Program will be offered on all ... , Order 4-19: Receive 10% discount - Order 20+: ... Using the Drawer Slides Products, ...
Breaking Medicine News(10 mins):Health News:Trivedi Master Wellness™ Announces the Resounding Success of their Special Prayers Human Wellness Program 2Health News:Trivedi Master Wellness™ Announces the Resounding Success of their Special Prayers Human Wellness Program 3Health News:Parker and Sons Plans to Expand in 2015 2Health News:Seeonic’s Industry Leading Technology Powers Interstate Batteries to Winning Award 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 3Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3
... HealthDay Reporter , WEDNESDAY, June 15 (HealthDay News) -- ... leading nations in terms of life expectancy, and the gap ... Life expectancy in some areas of the United States is ... nations, the report found. "The gap between the U.S. ...
... Reporter , WEDNESDAY, June 15 (HealthDay News) -- Severely ... fade or become less frequent after having weight-reducing gastric ... the three years following surgery, 70 percent of the ... saw their migraines reduced from five to two a ...
... as nave and irrational, can actually help consumers cope ... to a new study in the Journal of ... an individual invokes mystical, supernatural forces to understand, predict, ... write authors Yannik St. James (HEC Montreal), Jay M. ...
... 2011, the New York Academy of Sciences will ... molecular biologists and patient advocates to discuss current ... and management of the cognitive symptoms of MS. ... Dysfunction in Multiple Sclerosis: New Approaches to Diagnosis ...
... -- A person scanning baggage or X-rays stands a ... they aren,t feeling anxious, according to a new laboratory ... a test in which they searched for particular shapes ... searching performed by airport security teams and radiologists. ...
... of asbestos-contaminated dust, have a higher level of genetic somatic ... lower. This has been shown in a new study carried ... the University of Haifa,s Department of Biology in Oranim. "This ... higher levels of asbestos in the environment and the frequency ...
Cached Medicine News:Health News:U.S. Found to Be Losing Ground in Life Expectancy 2Health News:U.S. Found to Be Losing Ground in Life Expectancy 3Health News:For Many, Weight-Loss Surgery Also Eases Migraines 2Health News:For Many, Weight-Loss Surgery Also Eases Migraines 3Health News:Magical thinking helps dieters cope with unrealistic expectations 2Health News:The New York Academy of Sciences to host a symposium on cognitive dysfunction in multiple sclerosis 2Health News:Anxious searchers miss multiple objects 2Health News:Genetic mutation linked to asbestos exposure 2
(Date:4/23/2015)... HILL, S.C. , April 23, 2015 ... on and strengthening our commitment to patient safety. ... in the fight against infectious disease. The ... Medical gas sensors are now mounted in ... reducing the need to open ceiling tiles potentially releasing ...
(Date:4/23/2015)... April 23, 2015 Nektar Therapeutics (Nasdaq: NKTR ... ended March 31, 2015 on Thursday, April 30, 2015, after ... president and chief executive officer, will host a conference call ... (ET)/2:00 p.m. Pacific Time (PT). The press ... can be accessed through a link that is posted on ...
(Date:4/23/2015)... 23, 2015  DanDrit Biotech A/S ("DanDrit Denmark"), ... , Inc. ("DanDrit"), (symbol : OTCQB:DDRT) a ... for the treatment of colorectal cancer, announced that ... signed a partnership agreement in Saudi ... advances DanDrit,s goal to deliver an innovative portfolio ...
Breaking Medicine Technology:BeaconMedaes launches new Zone Valve Box Assembly 2Nektar to Announce Financial Results for the First Quarter 2015 on Thursday, April 30, 2015, After Close of U.S.-Based Financial Markets 2DanDrit Biotech and Riyadh Pharma Sign Partnership Agreement 2
... 2011 Henry Schein, Inc. (NASDAQ: ... services to office-based practitioners, announced today that Ferdinand ... the CL King 9th Annual Best Ideas Conference 2011. The ... New York City. Henry Schein,s presentation is ...
... VILLAGE, Nev., Sept. 13, 2011 PDL BioPharma, Inc. (PDL) ... McLaughlin, the company,s president and chief executive officer, will present ... ) UBS Global Life Sciences Conference ... The JMP Securities Healthcare Conference Tuesday, ...
Cached Medicine Technology:Henry Schein to Present at the CL King 9th Annual Best Ideas Conference 2011 2
Carl Zeiss has created a special configuration of the OPMI pico surgical microscope for neurosurgical applications, combining the benefits of optical excellence and superb illumination with outstandi...
... M501 TTS offers the comfort of a ... training application. The microscope offers brilliant resolution, ... and natural color reproduction. A separate prism ... be optimized with a special jalousie diaphragm. ...
... The Leica MS2 is designed to perfectly ... as multidisciplinary use. The Leica MS2 combines ... M500 N with a innovative stand concept ... brakes, patented ABC balancing system for the ...
... system has been designed to ... The maneuverability of this system ... fatigue-free viewing even at the ... in posterior fossa, cerebral tumor, ...
Medicine Products: