Navigation Links
New Chemistry Approach Promises Less Expensive Drugs

With a newly discovered method of assembling organic molecules, a team of Princeton University chemists may have found a way to sidestep many of the expensive// and hazardous barriers that stand in the way of drug development.

The new approach allows scientists to synthesize molecules without employing toxic catalysts, and it also does not generate alternate versions of drug molecules that can damage the body, two perennial issues that plague the manufacturing process. David MacMillan, one of the researchers on the team, said the discovery is important not only for its industrial applications, but also because of the new research possibilities it opens up.

"This is a new type of chemistry that could expand the way people think about making biologically active molecules," said MacMillan, who holds Princeton's A. Barton Hepburn Chair of Chemistry and directs the chemistry department's Merck Center for Catalysis. "We've found more than a new chemical reaction. It's a common mode of molecule activation that allows a whole group of reactions to take place."

Broadly stated, the discovery will open up new possibilities for working with ketones and aldehydes, two chemical groups that are found on a large percentage of the substances in which organic chemists are interested. "They form a big region of the reaction landscape," MacMillan said.

The paper, which MacMillan cowrote with first author Teresa Beeson, Anthony Mastracchio, Jun-Bae Hong and Kate Ashton, all members of his research group, appears in the March 29 issue of the journal Science. John Schwab, a chemist at the National Institutes of Health (NIH), applauded the work for the new possibilities it could provide.

"One sometimes hears that organic chemistry is a mature field, but MacMillan's work shows that there still are rich veins waiting to be mined," said Schwab, also a program director at the NIH's National Institute of General Medical Sciences, which
'"/>




Page: 1 2 3 4

Related medicine news :

1. Love And Drug Addiction Share The Same Chemistry
2. The Chemistry Of Sexual Attraction Between Male And Female Elephants
3. Chemistry Over The Counter: Is It Just What The Doctor Ordered?
4. New Dietary Approach To Manage Kidney Stones
5. Approaching through Telemedicine benefits patients
6. Gel Offers A More Targeted Approach
7. New Cost Effective Approach To Promote Sun Protection
8. Treatment Of Brain Aneurysms By A New Non-Surgical Approach
9. A New Approach In Treatment Neurogenic Detrusor Overactivity In Children
10. A New Diagnostic Approach To Pediatric Interstitial Lung Disease
11. Lazy Eye Can Be Effectively Treated By New Approach
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Chemistry Approach Promises Less Expensive Drugs

(Date:12/15/2014)... SUNDAY, Dec. 14, 2014 (HealthDay News) -- Expert pilots ... which explains why they make better decisions during landings, ... the most difficult techniques for pilots to master, and ... of fatal crashes occur during final approach and landing. ... pilots and 12 moderately experienced pilots while they were ...
(Date:12/15/2014)... Kathy McAfee, America's Marketing Motivator, was ... in the category of Best Blog 2014. McAfee received ... weekly career blog Networking Ahead which combines ... elevate their talent and influence through better networking, leadership ... book Networking Ahead for Business, has been motivating readers ...
(Date:12/15/2014)... Portland, OR (PRWEB) December 15, 2014 ... NAIRO seeks to bring attention to restrictive state ... new position paper on this important area of ... State Laws Can Compromise the Integrity of Independent ... quality and access of independent peer review determinations ...
(Date:12/15/2014)... Bacteroides is becoming the indicator of choice for assessing ... than coliforms, it cannot reproduce in the presence of oxygen ... Benefits of the new Bacteroides Sewage Screen:, ... false positives from coliforms naturally occurring in the environment , ... Maintain the same sampling method with results as quick as ...
(Date:12/15/2014)... 2014 For the second year in a ... 30 Coffees of 2014.” Bird Rock Coffee Roasters’ Sumatra Ulos ... Ethiopia at number 10. This is the first year that ... selection is ranked on quality, value, and other aspects, including ... out of 100, and at $17.99 for 12-ounces, was also ...
Breaking Medicine News(10 mins):Health News:Study Shows Why Expert Pilots Are Experts 2Health News:Kathy McAfee, America’s Marketing Motivator, Wins Best Blog from Women World Awards 2Health News:NAIRO Calls for Higher Quality Independent Peer Review By Ending Restrictive State Laws 2Health News:Bird Rock Coffee Roasters Ranks Second and Tenth in Coffee Review’s ‘Top 30 Coffees of 2014’ 2
... April 13 (HealthDay News) -- New data shows that youth ... of football injuries among players aged 6 to 17 who ... over 18 years, from 274,094 in 1990 to 346,772 in ... were an estimated 5.25 million football-related injuries among youngsters in ...
... aid treatment of learning impairments, strokes, tinnitus and chronic ... stimulation accelerates learning in laboratory tests. Another major ... issue of Neuron , involves the positive changes ... brain activity in rats found that brain responses eventually ...
... faced with more than the demise of a political system. ... a 40 percent surge in deaths between 1990 and 1994. ... clear. And for years, many economists and political scientists have ... men to drink. They reasoned that privatization left many people ...
... equals good, happy, optimistic; down the opposite. Right is ... language and culture tell us. "We use mental metaphors ... Daniel Casasanto, "One of those metaphors is space." ... Casasanto has found. Rather, "people associate goodness with the ...
... 2011 Elsevier, the leading publisher of scientific, ... announced the launch of Methods Navigator. This online ... and apply the right method for their research, ... joins Elsevier,s stable of workflow solutions including Hazmat ...
... Jenifer Goodwin HealthDay Reporter , WEDNESDAY, April 13 ... autism last December, Kristen Paurus and her husband, Bill, sought ... hometown of Sebeka, Minn., population 710, that,s not easy. ... their daughter, Brea, makes with her dad twice a week. ...
Cached Medicine News:Health News:Youth Football Injuries on the Rise, Study Finds 2Health News:Making temporary changes to brain could speed up learning, study reports 2Health News:Making temporary changes to brain could speed up learning, study reports 3Health News:Stanford research casts sober light on Russia's mortality crisis 2Health News:Stanford research casts sober light on Russia's mortality crisis 3Health News:Are your values right or left? The answer is more literal than you think 2Health News:'Best' Places to Live With Autism All in Major Metro Areas: Survey 2Health News:'Best' Places to Live With Autism All in Major Metro Areas: Survey 3
(Date:12/15/2014)... BOSTON , December 15, 2014 ... and development company, is pleased to announce the grant ... States relating to its GPCR-focused drug discovery ... significantly strengthens the global patent estate covering Heptares, technologies ... The suite of patents recently granted by the US ...
(Date:12/13/2014)... , Dec. 12, 2014  Radiologists can ... to images, to their referring physicians, electronic health ... using carefully selected technology.  That ... Data Systems Corporation (ADS) at the recent Radiology ... The transmitting of radiology reports in this manner ...
(Date:12/13/2014)... PLAINSBORO, N.J. and INDIANAPOLIS , ... diabetes care, and Chip Ganassi Racing Teams (CGRT), today announced ... Nordisk as the primary sponsor of the No. 83 Novo ... in the Verizon IndyCar Series. Kimball, ... first and only licensed driver with diabetes in the history ...
Breaking Medicine Technology:Heptares Extends Global Patent Protection for GPCR-Focused Drug Discovery Platform With Grant of Core Patents in the United States 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 2Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 4Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 5Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 6Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 7
... LTD. announced on August 20 that its collaborative study on ... Cholera and Enteric Diseases in Kolkata, India, showed that daily ... diarrhea in young children. An unprecedented large-scale study, ... Kolkata, was conducted. As a result, "Yakult" was shown to ...
... inflammation plays a surprising role reducing the level of infection caused ... patients and others with weakened immune systems. The drug, ... by enhancing the body,s ability to chew them up instead of ... to provoke an onslaught of harmful inflammation. Besides opening ...
Cached Medicine Technology:Daily Intake of 'Yakult' Is Efficacious in Reducing Incidence of Acute Diarrhea in Young Children 2Daily Intake of 'Yakult' Is Efficacious in Reducing Incidence of Acute Diarrhea in Young Children 3Old Drug Holds Promise Against Opportunistic Lung Bug 2Old Drug Holds Promise Against Opportunistic Lung Bug 3Old Drug Holds Promise Against Opportunistic Lung Bug 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: