Navigation Links
New Carrier Developed To Deliver Drugs to Gliomas

A new vehicle for delivering radioactive iodine dose to cure deadly brain tumors such as gliomas is under investigation.//

Synthetic scorpion venom is used as carriers for radioactive iodine. The first phase of the clinical trials is successfully complete and was conducted by under Adam N. Mamelak, M.D., a neurosurgeon at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute. About 18 patients participated in the trial and it was found to very safe. Now a larger phase two trial is underway to assess the effectiveness of multiple doses. The main advantage of this novel technique is that it does not affect the neighboring tissues or body organs. The study results are published in the Journal of Clinical Oncology. The key ingredient is TM-601, a synthetic version of a peptide, or protein particle, which naturally occurs in the venom of the Giant Yellow Israeli scorpion.

TM-601 binds to glioma cells and has an unusual ability to pass through the blood-brain barrier that blocks most substances from reaching brain tissue from the bloodstream. ‘We're using the TM-601 primarily as a carrier to transport radioactive iodine to glioma cells, although there are data to suggest that it may also slow down the growth of tumor cells. If studies continue to confirm this, we may be able to use it in conjunction with other treatments, such as chemotherapy, because there may be a synergistic effect. In other words, TM-601's ability to impede cancer growth could allow us to reduce the dose of chemotherapy to achieve a therapeutic effect,’ said Mamelak, who serves as co-director of the Pituitary Center at Cedars-Sinai.

About 17,000 Americans are diagnosed with gliomas each year. The tumors are extremely aggressive and deadly, with only eight percent of patients surviving two years and three percent surviving five years from time of diagnosis. Even when surgery is performed to remove a glioma, some cancer cells invariably remain behind and pro liferate. ‘Despite advances in surgical technology, radiation therapy and cancer-killing drugs, length of survival has remained virtually unchanged for patients with gliomas,’ said Keith L. Black, M.D., director of the Maxine Dunitz Neurosurgical Institute and interim chair of Cedars-Sinai's Department of Neurosurgery. ‘Only in the recent past have we begun to discover some of the molecular, genetic and immunologic mechanisms that enable these deadly cancer cells to evade or defy our treatments, and we are developing innovative approaches, such as this one, that capitalize on these revelations.’

Patients who consented to participate in the Phase I study first underwent tumor-removal surgery. Fourteen to 28 days later, a single, low dose of radioactive iodine (131I) attached to TM-601 was injected through a small tube into the cavity from which the tumor had been removed. Although TM-601 had been tested in earlier laboratory and animal experiments, it had never been given to humans. Therefore, the primary objective of this study was to document that 131I-TM-601 could be administered to humans safely. In addition, the researchers sought to begin to assess the drug's anti-tumor effect and dosing standards. Six patients agreed to receive additional doses at one of three different levels (.25 mg. of TM-601, .5 mg. of TM-601, and 1 mg. of TM-601, each carrying the same amount of iodine).

‘In this first human trial, treatment of patients with recurrent high-grade glioma with a single intracavitary dose of 131I-TM-601 was well tolerated to the maximum dose …. Very few adverse side effects occurred during the initial 22-day observation period, suggesting the dosing level of peptide used in this study is safe and well-tolerated in humans,’ the article states. While median length of survival for all patients was 27 weeks, two patients, women in their early 40s, had a ‘complete radiographic response,’ meaning there was no evidence of residual tumor accordi ng to magnetic resonance imaging scans. The patients were still alive beyond 33 and 35 months after surgery, despite the low dose of TM-601 and radiation levels that were below expected therapeutic levels. Analyses also showed that most of the radioactivity delivered by the drug left the region within 24 hours of administration.

That which lingered was ‘tightly localized to the tumor cavity and surrounding regions, suggesting discrete binding to the tumor.’ The drug was eliminated primarily through the urine, with radiation doses to the thyroid and other vital organs remaining extremely low and harmless. Mamelak said TM-601 binds to tumors other than gliomas, and this therapy will be studied in a variety of tumor types. He conducted this study with colleagues from City of Hope Cancer Center in Duarte, the University of Alabama at Birmingham, St. Louis University in Missouri, and TransMolecular, Inc., of Birmingham. TransMolecular also provided funding for the study.

Source:Eurekalert
'"/>




Related medicine news :

1. Alzheimer Gene Carriers Found To Have Memory Problems
2. Fruit Bats Act As Carriers of Ebola Virus
3. Financial Allowances Being Offered To Poor Vietnamese HIV Carriers
4. Coffee Reduces Risk of Breast Cancer in BRCA1 Mutation Carriers
5. A Carrier Protein Associates With Human Insulin Resistance
6. Genital Herpes - No Symptoms But A Potent Carrier
7. HIV Carriers Join Hands to Fight for their Rights
8. HIV Carriers Form an Association to Fight Social Stigma in Jharkhand
9. Carriers With Alzheimers High Risk Gene Type Age Normally Until the Disease Strikes
10. No Carrier Necessary: This Drug Delivers Itself
11. Scientists Developed Map For Brain Molecular Communities
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are ... for this recognition are considered among the top 2 percent of lawyers practicing within ... of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s ... the world, and the most handsome men, look naturally attractive. Plastic surgery should ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, ... economy by obtaining investment capital for emerging technology companies. SCP has delivered ... already resulted in more than a million dollars of capital investment for five ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 26, 2016 Story ... operating models within the health care industry is causing ... efficiency , Deloitte offers a suite of solutions ... issues impacting efficient cost optimization: labor resource analysis, revenue ... services facilitate better outcomes and better economics ...
(Date:6/24/2016)... 2016 Dublin ... addition of the " Global Markets for Spectroscopy ... This report focuses on the ... review, including its applications in various applications. The report ... includes three main industries: pharmaceutical and biotechnology, food and ...
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
Breaking Medicine Technology: