Navigation Links
New Cardiovascular Risk Prediction Models Developed for Women

Researchers have developed a more accurate way to predict the risk of developing cardiovascular disease among women, according// to a study in the issue of JAMA.

"In the decade between 1956 and 1966, investigators in Framingham, Mass., defined age, hypertension (high blood pressure), smoking, diabetes and hyperlipidemia (high cholesterol levels) as major determinants of coronary heart disease and coined the term coronary risk factors," according to background information provided by the authors. "Over time, these markers were codified into global risk scores for assessment of cardiovascular risk. However, for women, up to 20 percent of all coronary events occur in the absence of these major risk factors, whereas many women with traditional risk factors do not experience coronary events." The authors note that although understanding of cardiovascular disease has changed dramatically in the past half-century, the algorithms (predictive models) for women are largely unchanged from those recommended 40 years ago.

Paul M Ridker, M.D., M.P.H., from Brigham and Women's Hospital, Boston, and colleagues, developed and validated cardiovascular risk algorithms for women based on a large set of traditional and new risk factors. The researchers assessed 35 risk factors among 24,558 initially healthy women (free of cardiovascular disease and cancer at the beginning of the study) 45 years or older from the Women's Health Study who were followed up for a median of 10.2 years for incident (new) cardiovascular events, such as myocardial infarction (heart attack), ischemic stroke, coronary revascularization, and cardiovascular deaths. The researchers used data among a randomly selected two-thirds of the women (n = 16,400) to develop new algorithms that were then tested to compare observed and predicted outcomes in the remaining one-third of women (n = 8,158). The new algorithms are called the Reynolds Risk Score and the clinically simplified model for non-diab etic women includes age, systolic blood pressure, current smoking, total and HDL cholesterol, high sensitivity C-reactive protein (CRP) and parental history of myocardial infarction before age 60.

"In these analyses, large proportions of women with 10-year risk estimates of 5 percent to less than 10 percent or of 10 percent to less than 20 percent based on current ATP-III (Adult Treatment Panel III) risk scores were reclassified at either higher or lower risk of total cardiovascular disease when either of the new algorithms was used," the researchers found.

"We developed, validated and demonstrated highly improved accuracy of two clinical algorithms for global cardiovascular risk prediction that reclassified 40 percent to 50 percent of women at intermediate risk into higher- or lower-risk categories," the authors write. "As 8 to 10 million U.S. women have an ATP-III estimated 10-year risk between 5 percent and 20 percent, application of these data could have an immediate effect on cardiovascular prevention," the authors conclude.


Related medicine news :

1. High iron levels may cause Cardiovascular Disease in women
2. Air Pollution said To Increase Risk of Cardiovascular Disease
3. Link Between Alcohol Consumption And Cardiovascular Disease
4. Beer Found To Be Effective In Fighting Cardiovascular Disease
5. New Guidelines Found To Benefit Cardiovascular Treatment
6. Women With A High-Risk Of Cardiovascular Disease Under treated
7. Obesity and Physical inactivity is associated with Diabetes and Diabetes-Related Cardiovascular Comorbidities
8. Fitness levels in Men Correale with risk of Cardiovascular disease
9. Obesity Common Thread In Pregnancy Complications And Cardiovascular Woes
10. Olive Oil Found To Preserve Cardiovascular Health by Improving Function
11. Novel Rules And Regulations For Cardiovascular Catheterization Labs.
Post Your Comments:

(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Conventional wisdom ... of success. In terms of the latter, setting the bar too high can result ... more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016  Collagen Matrix, Inc., ("Collagen Matrix") the ... of collagen and mineral based medical devices for ... Bill Messer has joined the company as ... the growing portfolio of oral surgery, neurosurgery, orthopaedic ... joins the Collagen Matrix executive team as an ...
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... 2016 Research and Markets ... Electronics 2015-2025: Applications, Technologies, Forecasts" report to ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, Composite ... Structural electronics involves electronic and/or electrical components and ... dumb structures such as vehicle bodies or conformally ...
Breaking Medicine Technology: