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New Blood Thinner Pill - First Potential Alternative to Warfarin in 50 years

Warfarin, originally developed as a rat poison, was first used as a blood thinner in the 1950s. It is still the only oral blood thinner available to protect against clots that can block blood vessels. It is widely prescribed after //strokes, heart attacks and orthopedic surgery and is also given to prevent recurring clots in the legs or lungs. But warfarin, which takes time to kick in, interacts with other drugs and foods containing vitamin K. It requires regular blood tests to adjust the dose. Doctors are wary of using it for more than a few months because of the risk of bleeding.

The new drug has been tested in 17,000 patients for a number of uses and has shown to work as well as or, in some cases, better than warfarin at preventing dangerous blood clots. It acts more quickly and does not require the frequent blood testing of warfarin, also known as Coumadin.

According to the study it has shown a reduce the risk of blood clots by one-quarter after knee replacement surgery, and substantially cut the long-term risk of another clot developing in patients who had a blood clot in a leg or lung.

Doctors say they think in most cases it will replace warfarin because it is much easier and seems safer also, but it will take some time, before patients could be switched over to the new drug.

The Swedish study of 1,223 patients in 18 countries tested Exanta for the prevention of recurrent clots in people who had a leg or lung clot. They entered the study after getting warfarin for six months. For the next 18 months they got Exanta or a dummy pill.

Recurrent clots were found in 12 patients in the Exanta group and 71 in the comparison group, a reduction of 84 percent. Major bleeding was low in both groups. Six patients died in the Exanta group and seven in the comparison, including three of suffered fatal lung clots.

In about 6 percent of the Exanta group, there was an unexplained increase in liver enzymes, which has be
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