Navigation Links
New Asthma Medicine Targeting Vulnerable Inner-City Children Tested

UT Southwestern Medical Center is one of a handful of top research institutions evaluating a promising new medication researchers hope can reduce the severity and frequency of// asthma attacks in inner-city children, a population known to have a high prevalence of severe asthma.

“Children living in inner cities are exposed to higher allergen levels and tend to have more severe asthma than children living elsewhere,” said Dr. Rebecca Gruchalla, chief of allergy at UT Southwestern. “We want to see whether this new treatment can help children with allergic asthma, for which the environmental factors are more difficult to control.”

Indoor allergens commonly found in inner cities, such as dust mites, cockroaches, molds and animal dander, are significant allergens that may contribute to the severity of a child’s asthma. UT Southwestern, along with 10 other sites around the country, is participating in a National Institutes of Health-supported evaluation of anti-IgE therapy for children. This therapy is already being used successfully in adults and adolescents who have asthma.

“IgE antibodies are the fuel in the immune system that perpetuates the asthmatic reaction,” said Dr. Gruchalla, serves as principal investigator at the Dallas site. Some people are more genetically prone to develop IgE antibodies, which are molecules produced by white blood cells in response to exposure to allergens. IgE antibodies can make asthma worse in those people who are sensitive to particular allergens.

The Inner City Anti-IgE Therapy for Asthma (ICATA) study involves about 50 children at each site. It will evaluate Xolair (omalizumab), a drug that binds to and inactivates IgE antibodies.

“Xolair ‘sops up’ the IgE that’s there, decreases the receptors for IgE, and regulates many things that pertain to allergy and the asthmatic response,” Dr. Gruchalla said.

The two-year Dallas portion of the study targets children 6 to 20 years old w ho reside within the Dallas Independent School District. Individuals interested in participating should call 214-648-5436 for additional requirements and information.

Participating children will receive an injection every two or four weeks and medical care for their asthma for nearly two years. Laboratory analyses of biological and environmental samples from the home also will occur during the same time period.

The $15 million study is funded through the Inner-City Asthma Consortium (ICAC), an NIH-sponsored, $55.8 million, six-year contract to investigate treatments and causes of asthma in urban children. Novartis Pharmaceuticals Corp. and Genentech, which are providing about $8 million toward the study, are also donating an additional $6 million in medication. The balance of funding will be provided by the National Institute of Allergy and Infectious Diseases.

The consortium is administered by the University of Wisconsin-Madison. Other research sites in addition to UT Southwestern are: the University of Arizona, Boston University, Children's Memorial Hospital in Chicago, Rainbow Babies and Children’s Hospital in Cleveland, Children’s National Medical Center in Washington, D.C., National Jewish Medical and Research Center in Denver, Johns Hopkins University, Mount Sinai School of Medicine, and St. Louis Children’s Hospital.

Dr. Gruchalla has led the Dallas arm of the Inner City Asthma Consortium for four years. She is also principal investigator of an asthma screening project in Dallas schools and project director for Community Leadership in Preventing Asthma, a study evaluating links between asthma-associated morbidity and allergen levels in schools and homes.

Other UT Southwestern investigators in the ICATA study are Dr. William Neaville, clinical assistant professor of pediatrics and internal medicine, and Dr. Vanthaya Gan, clinical professor of pediatrics.

Source-Nwswise
SRM
'"/>




Related medicine news :

1. New Drug for Bronchial Asthma
2. Asthma may actually be prevented by Dust and Dirt
3. Inhaled Steroids Safe & Effective for Children with Asthma
4. What happens when Asthmatics consume Aspirin?
5. Asthma! A new warning for heart disease
6. Asthma linked to obesity
7. Higher Risk of Asthma in children with autoimmune disease
8. Asthmatics at increased risk of lung cancer
9. Cleanliness might lead to Asthma
10. Asthma is not just a childhood condition
11. Asthma not just a childhood condition
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... ... ... With expansion and efficiency in mind, Patten Seed Company completed relocation of its ... in Marshallville in 2006, and a bagging and shipping facility has been in place ... Seed operations to the Middle Georgia location from their previous home in Lakeland, Georgia. ...
(Date:3/28/2017)... ... , ... Oily skin is a common and unwelcomed occurrence in people of all ages, genders ... offer to the discussion of dealing with excess skin oil. “Oily skin is a challenge ... that can help remove the oily shine while keeping the skin fresh and clean,” says ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... job satisfaction in their profession as their value increases in the healthcare workforce, ... provides resources such as job boards, career fairs, and candidate leads to healthcare ...
(Date:3/28/2017)... ... 28, 2017 , ... Bacteria and fungi are probably not the first ingredients that come to ... the right microorganisms in your diet can actually improve health outcomes. And the good news ... the topic of a new peer-reviewed paper led by Maria Marco, Ph.D. ...
(Date:3/27/2017)... FL (PRWEB) , ... March 27, 2017 , ... ... new patients for clear braces. People who want straight teeth without the extensive ... Invisalign® in Clearwater, FL, without acquiring a referral. A custom-designed series of ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... IRVINE, Calif. , March 27, 2017 ... living in the wealthiest countries have access to the ... affluent countries like the US, many patients have inadequate ... devastating debts or skip therapy altogether. Access to modern ... in less affluent countries. The mission ...
(Date:3/27/2017)... YORK , March 27, 2017 ... colors as the NASDAQ Composite closed the trading session ... lower; and the S&P 500 was down 0.08%. US ... nine sectors finishing the day in green. Pre-market today, ... Wright Medical Group N.V. (NASDAQ: WMGI), Amedica Corporation (NASDAQ: ...
(Date:3/27/2017)... 27, 2017  Twist Bioscience, a company accelerating science ... that it raised an additional $33 million. To date, ... "It is an exciting time to ... and continue to deliver industry-leading gene volume to our ... Emily M. Leproust, Ph.D., CEO of Twist Bioscience. "We ...
Breaking Medicine Technology: